Translation initiation factor eIF4F modifies the dexamethasone response in multiple myeloma (Q34218069)

25197055

31 July 2017

title

Translation initiation factor eIF4F modifies the dexamethasone response in multiple myeloma (English)

1 reference

31 July 2017

1 reference

1 reference

2

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1 June 2020

Christof Fellmann

4

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1 June 2020

Jerry Pelletier

10

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1 June 2020

author name string

Francis Robert

1

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1 June 2020

Alexandre Bramoullé

3

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1 June 2020

Anne Roulston

5

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1 June 2020

Chaim Shustik

6

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1 June 2020

John A Porco

7

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1 June 2020

Gordon C Shore

8

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Michael Sebag

9

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1 June 2020

language of work or name

English

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publication date

2 September 2014

1 reference

25197055

Proceedings of the National Academy of Sciences of the United States of America

31 July 2017

published in

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volume

111

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issue

37

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1 June 2020

page(s)

13421-13426

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25197055%20AND%20SRC:MED&resulttype=core&format=json

Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers

1 June 2020

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5 July 2018

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The cap-translation inhibitor 4EGI-1 induces apoptosis in multiple myeloma through Noxa induction.

5 July 2018

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PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis

5 July 2018

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The mammalian target of rapamycin pathway as a therapeutic target in multiple myeloma

5 July 2018

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Clinical and biological implications of MYC activation: a common difference between MGUS and newly diagnosed multiple myeloma.

5 July 2018

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Initial genome sequencing and analysis of multiple myeloma

5 July 2018

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Targeting TORC2 in multiple myeloma with a new mTOR kinase inhibitor.

5 July 2018

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Antimyeloma activity of the orally bioavailable dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235.

5 July 2018

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DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

5 July 2018

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Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol

5 July 2018

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Multiple myeloma: biology, standard therapy, and transplant therapy

5 July 2018

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c-Myc and eIF4F are components of a feedforward loop that links transcription and translation

5 July 2018

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Targeting the eukaryotic translation initiation factor 4E for cancer therapy

5 July 2018

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Dissecting eIF4E action in tumorigenesis

5 July 2018

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Glucocorticoid receptor transcriptional isoforms and resistance in multiple myeloma cells

5 July 2018

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Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance

5 July 2018

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Mechanism by which mammalian target of rapamycin inhibitors sensitize multiple myeloma cells to dexamethasone-induced apoptosis

5 July 2018

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Mammalian target of rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate-1/phosphatidylinositol 3-kinase cascade.

5 July 2018

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Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival.

5 July 2018

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Combination of the mTOR inhibitor rapamycin and CC-5013 has synergistic activity in multiple myeloma

5 July 2018

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eIF-4E expression and its role in malignancies and metastases.

5 July 2018

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Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone.

5 July 2018

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Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

5 July 2018

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5 July 2018

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eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation

5 July 2018

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Diverse karyotypic abnormalities of the c-myc locus associated with c-myc dysregulation and tumor progression in multiple myeloma

5 July 2018

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A new dexamethasone-induced gene of the leucine zipper family protects T lymphocytes from TCR/CD3-activated cell death

5 July 2018

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A novel functional human eukaryotic translation initiation factor 4G

5 July 2018

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Increased expression of eukaryotic translation initiation factors eIF-4E and eIF-2 alpha in response to growth induction by c-myc

5 July 2018

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5 July 2018

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5 July 2018

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IL-6-independent expression of Mcl-1 in human multiple myeloma

28 October 2018

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Glucocorticoid-receptor-gene defects and resistance to glucocorticoid-induced apoptosis in human leukemic cell lines

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25197055

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Lymphoid neoplasms associated with concurrent t(14;18) and 8q24/c-MYC translocation generally have a poor prognosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25197055

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1402650111

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1 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25197055%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

25197055

1 reference