Naturally occurring mutations of the extracellular Ca2+-sensing receptor: implications for its structure and function (Q34218479)

31 July 2017

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title

Naturally occurring mutations of the extracellular Ca2+-sensing receptor: implications for its structure and function (English)

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31 July 2017

Jianxin Hu

1

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PubMed ID

12890593

31 July 2017

Allen M Spiegel

series ordinal

2

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31 July 2017

1 August 2003

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Trends in Endocrinology and Metabolism

31 July 2017

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31 July 2017

14

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31 July 2017

6

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31 July 2017

282-288

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Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid

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Extracellular calcium sensing and extracellular calcium signaling

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The extracellular calcium-sensing receptor: its role in health and disease

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Ca(2+) receptor from brain to gut: common stimulus, diverse actions.

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Calcimimetic Compounds: a Direct Approach to Controlling Plasma Levels of Parathyroid Hormone in Hyperparathyroidism

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Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor

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Cooperative multi-modal sensing and therapeutic implications of the extracellular Ca(2+) sensing receptor

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Identification of the sites of N-linked glycosylation on the human calcium receptor and assessment of their role in cell surface expression and signal transduction

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Expression, purification, and biochemical characterization of the amino-terminal extracellular domain of the human calcium receptor

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Human Ca(2+) receptor extracellular domain. Analysis of function of lobe I loop deletion mutants

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Functional importance of the Ala(116)-Pro(136) region in the calcium-sensing receptor. Constitutive activity and inverse agonism in a family C G-protein-coupled receptor

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The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain

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Human Ca2+ receptor cysteine-rich domain. Analysis of function of mutant and chimeric receptors

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Functional interactions between the extracellular domain and the seven-transmembrane domain in Ca2+ receptor activation

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Three adjacent serines in the extracellular domains of the CaR are required for L-amino acid-mediated potentiation of receptor function

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Mutational analysis of the cysteines in the extracellular domain of the human Ca2+ receptor: effects on cell surface expression, dimerization and signal transduction

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Structural views of the ligand-binding cores of a metabotropic glutamate receptor complexed with an antagonist and both glutamate and Gd3+.

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Amino acid mutagenesis of the ligand binding site and the dimer interface of the metabotropic glutamate receptor 1. Identification of crucial residues for setting the activated state

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The extracellular calcium-sensing receptor dimerizes through multiple types of intermolecular interactions

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Identification of the cysteine residues in the amino-terminal extracellular domain of the human Ca(2+) receptor critical for dimerization. Implications for function of monomeric Ca(2+) receptor

1 reference

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Intermolecular interactions between dimeric calcium-sensing receptor monomers are important for its normal function

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7 January 2021

The Venus's-flytrap and cysteine-rich domains of the human Ca2+ receptor are not linked by disulfide bonds

1 reference

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7 January 2021

Identification of acidic residues in the extracellular loops of the seven-transmembrane domain of the human Ca2+ receptor critical for response to Ca2+ and a positive allosteric modulator

1 reference

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7 January 2021

The carboxyl terminus of the human calcium receptor. Requirements for cell-surface expression and signal transduction.

1 reference

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7 January 2021

A carboxyl-terminal domain controls the cooperativity for extracellular Ca2+ activation of the human calcium sensing receptor. A study with receptor-green fluorescent protein fusions

1 reference

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7 January 2021

Filamin-A binds to the carboxyl-terminal tail of the calcium-sensing receptor, an interaction that participates in CaR-mediated activation of mitogen-activated protein kinase

1 reference

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Familial hypocalciuric hypercalcemia caused by an R648stop mutation in the calcium-sensing receptor gene

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Mutations of the calcium-sensing receptor (CASR) in familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia

1 reference

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Functional Characterization of a Calcium-Sensing Receptor Mutation in Severe Autosomal Dominant Hypocalcemia with a Bartter-Like Syndrome

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Association between activating mutations of calcium-sensing receptor and Bartter's syndrome

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A large homozygous or heterozygous in-frame deletion within the calcium-sensing receptor's carboxylterminal cytoplasmic tail that causes autosomal dominant hypocalcemia

1 reference

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7 January 2021

A missense mutation in the seventh transmembrane domain constitutively activates the human Ca2+ receptor

1 reference

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7 January 2021

Calcimimetics: therapeutic potential in hyperparathyroidism

1 reference

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7 January 2021

L-phenylalanine and NPS R-467 synergistically potentiate the function of the extracellular calcium-sensing receptor through distinct sites

1 reference

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7 January 2021

Allosteric modulators of group I metabotropic glutamate receptors: novel subtype-selective ligands and therapeutic perspectives.

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Mutational analysis and molecular modeling of the allosteric binding site of a novel, selective, noncompetitive antagonist of the metabotropic glutamate 1 receptor

1 reference

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7 January 2021

10.1016/S1043-2760(03)00104-8

Identifiers

DOI

1 reference

31 July 2017

1 reference

PubMed ID

12890593