A high-throughput single-cell analysis of human CD8⁺ T cell functions reveals discordance for cytokine secretion and cytolysis (Q34220876)

31 July 2017

title

A high-throughput single-cell analysis of human CD8⁺ T cell functions reveals discordance for cytokine secretion and cytolysis (English)

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31 July 2017

1

Navin Varadarajan

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31 July 2017

11

Florencia Pereyra

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31 July 2017

Alicja Piechocka-Trocha

8

object named as

Alicja Piechocka-Trocha

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31 July 2017

2

Boris Julg

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31 July 2017

10

Daniel C Douek

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31 July 2017

9

Brenna J Hill

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31 July 2017

Yvonne J Yamanaka

3

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31 July 2017

Huabiao Chen

4

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31 July 2017

Adebola O Ogunniyi

5

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31 July 2017

Elizabeth McAndrew

6

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31 July 2017

Lindsay C Porter

7

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31 July 2017

Bruce D Walker

12

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31 July 2017

J Christopher Love

13

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31 July 2017

language of work or name

English

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publication date

3 October 2011

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Journal of Clinical Investigation

31 July 2017

published in

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31 July 2017

volume

121

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31 July 2017

issue

11

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31 July 2017

page(s)

4322-4331

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Living in a house of cards: re-evaluating CD8+ T-cell immune correlates against HIV

31 July 2017

cites work

1 reference

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Multidimensional analysis of the frequencies and rates of cytokine secretion from single cells by quantitative microengraving

28 July 2018

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28 July 2018

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Dynamic regulation of functionally distinct virus-specific T cells

28 July 2018

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Development and optimization of a process for automated recovery of single cells identified by microengraving

28 July 2018

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Potent HIV-specific responses are enriched in a unique subset of CD8+ T cells that coexpresses CD4 on its surface

28 July 2018

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Screening individual hybridomas by microengraving to discover monoclonal antibodies

28 July 2018

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Distinct profiles of cytotoxic granules in memory CD8 T cells correlate with function, differentiation stage, and antigen exposure

28 July 2018

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28 July 2018

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Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control

28 July 2018

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High-programmed death-1 levels on hepatitis C virus-specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infection

28 July 2018

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Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies

28 July 2018

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28 July 2018

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28 July 2018

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Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells

28 July 2018

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T-cell quality in memory and protection: implications for vaccine design

28 July 2018

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Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover

28 July 2018

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Availability of a diversely avid CD8+ T cell repertoire specific for the subdominant HLA-A2-restricted HIV-1 Gag p2419-27 epitope

28 July 2018

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HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8(+) T Cell Response against HIV-1.

28 July 2018

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28 July 2018

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HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells

28 July 2018

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Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells

28 July 2018

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IMGT unique numbering for immunoglobulin and T cell receptor variable domains and Ig superfamily V-like domains

28 July 2018

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A significant number of human immunodeficiency virus epitope-specific cytotoxic T lymphocytes detected by tetramer binding do not produce gamma interferon

28 July 2018

1 reference

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Perforin and Fas killing by CD8+ T cells limits their cytokine synthesis and proliferation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204845

Synergistic inhibition of human immunodeficiency virus type 1 and type 2 replication in vitro by castanospermine and 3'-azido-3'-deoxythymidine

28 July 2018

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28 July 2018

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The major genetic determinants of HIV-1 control affect HLA class I peptide presentation

28 July 2018

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Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control

28 October 2018

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Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity

28 October 2018

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The role of IFN-gamma Elispot assay in HIV vaccine research

28 October 2018

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Differential neutralization of human immunodeficiency virus (HIV) replication in autologous CD4 T cells by HIV-specific cytotoxic T lymphocytes

28 October 2018

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HIV-1-specific IFN-gamma/IL-2-secreting CD8 T cells support CD4-independent proliferation of HIV-1-specific CD8 T cells.

28 October 2018

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The functional profile of primary human antiviral CD8+ T cell effector activity is dictated by cognate peptide concentration

28 October 2018

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Measuring the frequency of mouse and human cytotoxic T cells by the Lysispot assay: independent regulation of cytokine secretion and short-term killing

28 October 2018

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Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204845

Arrested differentiation, the self-renewing memory lymphocyte, and vaccination.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204845

Skewed maturation of memory HIV-specific CD8 T lymphocytes

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204845

A re-evaluation of the frequency of CD8+ T cells specific for EBV in healthy virus carriers.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204845

Role of TNF-alpha in CD8+ cytotoxic T lymphocyte-mediated lysis.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204845

Most antiviral CD8 T cells during chronic viral infection do not express high levels of perforin and are not directly cytotoxic

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204845

HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors

28 October 2018

1 reference

12 December 2020

Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation

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A routine method for the establishment of permanent growing lymphoblastoid cell lines

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Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS

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Intracellular cytokine optimization and standard operating procedure

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Measuring HIV-1-specific T cell immunity: how valid are current assays?

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Identifiers

DOI

10.1172/JCI58653

1 reference

31 July 2017

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31 July 2017

1 reference