Shikonin, a component of chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1 (Q34224950)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12936978%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

title

Shikonin, a component of chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1 (English)

1 reference

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7 November 2019

0 references

8

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7 November 2019

Xin Chen

1

1 reference

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7 November 2019

5

Robert W Buckheit

1 reference

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7 November 2019

author name string

Lu Yang

2

1 reference

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7 November 2019

Ning Zhang

3

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7 November 2019

Jim A Turpin

4

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7 November 2019

Clay Osterling

6

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7 November 2019

Joost J Oppenheim

7

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7 November 2019

language of work or name

English

0 references

publication date

1 September 2003

1 reference

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Antimicrobial Agents and Chemotherapy

7 November 2019

published in

1 reference

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7 November 2019

volume

47

1 reference

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7 November 2019

issue

9

1 reference

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7 November 2019

page(s)

2810-2816

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describes a project that uses

7 November 2019

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC182643/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Cellular pharmacology studies of shikonin derivatives.

1 reference

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HIV's response to a CCR5 inhibitor: I'd rather tighten than switch!

5 July 2018

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Regulatory effects of deoxycholic acid, a component of the anti-inflammatory traditional Chinese medicine Niuhuang, on human leukocyte response to chemoattractants

5 July 2018

1 reference

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Shikonin, a component of antiinflammatory Chinese herbal medicine, selectively blocks chemokine binding to CC chemokine receptor-1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=182643

Human immunodeficiency virus type-1 and chemokines: beyond competition for common cellular receptors

5 July 2018

1 reference

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5 July 2018

Chemokines and disease

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Higher macrophage inflammatory protein (MIP)-1alpha and MIP-1beta levels from CD8+ T cells are associated with asymptomatic HIV-1 infection

5 July 2018

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A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry.

5 July 2018

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International union of pharmacology. XXII. Nomenclature for chemokine receptors

5 July 2018

1 reference

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Antiretroviral therapy in adults: updated recommendations of the International AIDS Society-USA Panel

5 July 2018

1 reference

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A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=182643

Activation of human monocytes induces differential resistance to apoptosis with rapid down regulation of caspase-8/FLICE.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=182643

Cytokine regulation of human immunodeficiency virus type 1 entry and replication in human monocytes/macrophages through modulation of CCR5 expression.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=182643

Regulation of the receptor specificity and function of the chemokine RANTES (regulated on activation, normal T cell expressed and secreted) by dipeptidyl peptidase IV (CD26)-mediated cleavage

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=182643

Interaction of chemokine receptor CCR5 with its ligands: multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=182643

The second extracellular loop of CCR5 is the major determinant of ligand specificity.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=182643

Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=182643

Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=182643

Identification of a major co-receptor for primary isolates of HIV-1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=182643

HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=182643

Structure-activity and cross-resistance evaluations of a series of human immunodeficiency virus type-1-specific compounds related to oxathiin carboxanilide

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=182643

Extension of recombinant human RANTES by the retention of the initiating methionine produces a potent antagonist.

5 July 2018

1 reference

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Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=182643

Potent and specific inhibition of HIV envelope-mediated cell fusion and virus binding by G quartet-forming oligonucleotide (ISIS 5320).

5 July 2018

1 reference

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Microculture tetrazolium assays: a comparison between two new tetrazolium salts, XTT and MTS.

5 July 2018

1 reference

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Biological and biochemical anti-HIV activity of the benzothiadiazine class of nonnucleoside reverse transcriptase inhibitors

5 July 2018

1 reference

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Inhibitory effects of quinones on RNase H activity associated with HIV-1 reverse transcriptase

5 July 2018

1 reference

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Anti-HIV-1 activities of crude drug, shikon (Lithospermi radix), in vitro

28 October 2018

1 reference

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The Chemistry and Biology of Alkannin, Shikonin, and Related Naphthazarin Natural Products

28 October 2018

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12 December 2020

A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migration

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12 December 2020

[Screening test of crude drug extract on anti-HIV activity]

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12 December 2020

Impairment of phosphatidylinositol signaling in acetylshikonin-treated neutrophils

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12 December 2020

10.1128/AAC.47.9.2810-2816.2003

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12936978%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12936978%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

1 reference