Biochemical mechanisms of HIV induced T cell apoptosis (Q34225886)

31 July 2017

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title

Biochemical mechanisms of HIV induced T cell apoptosis (English)

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31 July 2017

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Selliah N

1

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PubMed ID

11313714

31 July 2017

Finkel TH

series ordinal

2

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31 July 2017

1 February 2001

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Cell Death & Differentiation

31 July 2017

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31 July 2017

8

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31 July 2017

2

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31 July 2017

127-136

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https://scigraph.springernature.com/pub.10.1038/sj.cdd.4400822

31 July 2017

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Apoptosis of CD4+ and CD8+ T cells isolated immediately ex vivo correlates with disease severity in human immunodeficiency virus type 1 infection

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7 January 2021

Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans

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7 January 2021

Limited CD4+ T-cell renewal in early HIV-1 infection: effect of highly active antiretroviral therapy.

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7 January 2021

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas.

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Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

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7 January 2021

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation.

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7 January 2021

Role of the Fas/Fas ligand apoptotic pathway in human immunodeficiency virus type 1 disease

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7 January 2021

Does HIV cause depletion of CD4+ T cells in vivo by the induction of apoptosis?

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7 January 2021

Overexpression of Fas antigen on T cells in advanced HIV-1 infection: differential ligation constantly induces apoptosis

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7 January 2021

Fas (CD95) expression on CD4+ T cells from HIV-infected patients increases with disease progression

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7 January 2021

Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals.

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7 January 2021

Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120.

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7 January 2021

Human immunodeficiency virus type 1 Tat induces apoptosis and increases sensitivity to apoptotic signals by up-regulating FLICE/caspase-8.

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7 January 2021

Differential requirement for p56lck in HIV-tat versus TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal kinase, and apoptosis

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7 January 2021

The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore

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7 January 2021

High levels of HIV-1 replication show a clear correlation with downmodulation of Bcl-2 protein in peripheral blood lymphocytes of HIV-1-seropositive subjects

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7 January 2021

Downregulation of Bcl-2, but not of Bax or Bcl-x, is associated with T lymphocyte apoptosis in HIV infection and restored by antiretroviral therapy or by interleukin 2

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7 January 2021

Apoptosis mediated by HIV protease is preceded by cleavage of Bcl-2

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7 January 2021

A cellular anti-apoptosis protein is cleaved by the HIV-1 protease

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7 January 2021

STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells

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7 January 2021

Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL

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7 January 2021

Cell cycle arrest by Vpr in HIV-1 virions and insensitivity to antiretroviral agents.

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7 January 2021

Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity

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7 January 2021

Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B

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7 January 2021

Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A

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7 January 2021

A carboxy-terminally truncated form of the human immunodeficiency virus type 1 Vpr protein induces apoptosis via G(1) cell cycle arrest

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7 January 2021

Human immunodeficiency virus type 1 vpr induces apoptosis through caspase activation

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Frequency of provirus-bearing CD4+ cells in HIV type 1 infection correlates with extent of in vitro apoptosis of CD8+ but not of CD4+ cells

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Kinetics of CD4+ T cell repopulation of lymphoid tissues after treatment of HIV-1 infection

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

CD4+ blood lymphocytes are rapidly killed in vitro by contact with autologous human immunodeficiency virus-infected cells.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

HIV-1 envelope induces activation of caspase-3 and cleavage of focal adhesion kinase in primary human CD4(+) T cells

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Effects of human immunodeficiency virus type 1 on CD4 lymphocyte subset activation.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Caspase-dependent apoptosis of cells expressing the chemokine receptor CXCR4 is induced by cell membrane-associated human immunodeficiency virus type 1 envelope glycoprotein (gp120).

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Caspases cleave focal adhesion kinase during apoptosis to generate a FRNK-like polypeptide.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Cleavage of focal adhesion kinase by caspases during apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Interleukin-1 beta converting enzyme-like protease involvement in Fas-induced and activation-induced peripheral blood T cell apoptosis in HIV infection. TNF-related apoptosis-inducing ligand can mediate activation-induced T cell death in HIV infecti

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Diminished spontaneous apoptosis in lymphocytes from human immunodeficiency virus-infected long-term nonprogressors

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Janus kinase 3 (Jak3) is essential for common cytokine receptor gamma chain (gamma(c))-dependent signaling: comparative analysis of gamma(c), Jak3, and gamma(c) and Jak3 double-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

STATs and gene regulation

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Jaks, STATs, cytokine signal transduction, and immunoregulation: are we there yet?

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Human immunodeficiency virus 1 Tat binds to dipeptidyl aminopeptidase IV (CD26): a possible mechanism for Tat's immunosuppressive activity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Role of CD26/dipeptidyl peptidase IV in human immunodeficiency virus type 1 infection and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Apoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Viral proteins that regulate cellular signalling.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

The inhibition of pro-apoptotic ICE-like proteases enhances HIV replication

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

HIV1 Nef: the Machiavelli of cellular activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

The T-cell receptor zeta chain contains two homologous domains with which simian immunodeficiency virus Nef interacts and mediates down-modulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Qualitative and quantitative contributions of the T cell receptor zeta chain to mature T cell apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Reciprocal modulations between p53 and Tat of human immunodeficiency virus type 1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Loss of G(1)/S checkpoint in human immunodeficiency virus type 1-infected cells is associated with a lack of cyclin-dependent kinase inhibitor p21/Waf1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

The HIV-1 vpr protein acts as a negative regulator of apoptosis in a human lymphoblastoid T cell line: possible implications for the pathogenesis of AIDS

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Mapping of HIV-1 determinants of apoptosis in infected T cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

The cell death-inducing ability of glycoprotein 120 from different HIV strains correlates with their ability to induce CD4 lateral association with CD95 on CD4+ T cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

CD8 naive T cell counts decrease progressively in HIV-infected adults

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: a composite of redistribution and proliferation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Effects of subcutaneous interleukin-2 therapy on CD4 subsets and in vitro cytokine production in HIV+ subjects

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Immune reconstitution in HIV infection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Effects of therapy with highly active anti-retroviral therapy (HAART) and IL-2 on CD4+ and CD8+ lymphocyte apoptosis in HIV+ patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Low-dose IL-2 reduces lymphocyte apoptosis and increases naive CD4 cells in HIV-1 patients treated with HAART

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Concomitant therapy with subcutaneous interleukin-2 and zidovudine plus didanosine in patients with early stage HIV infection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Increases in CD4 T lymphocytes with intermittent courses of interleukin-2 in patients with human immunodeficiency virus infection. A preliminary study

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Dynamics of Provirus Load and Lymphocyte Subsets after Interleukin 2 Treatment in HIV-Infected Patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Interleukin-15 is a potent survival factor in the prevention of spontaneous but not CD95-induced apoptosis in CD4 and CD8 T lymphocytes of HIV-infected individuals. Correlation with its ability to increase BCL-2 expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Human immunodeficiency virus 1 envelope-initiated G2-phase programmed cell death

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Productive infection and subsequent interaction of CD4-gp120 at the cellular membrane is required for HIV-induced apoptosis of CD4+ T cells.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Membrane alterations linked to early interactions of HIV with the cell surface

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Participation of tyrosine phosphorylation in the cytopathic effect of human immunodeficiency virus-1

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Binding of human immunodeficiency virus type 1 to CD4 induces association of Lck and Raf-1 and activates Raf-1 by a Ras-independent pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

HIV and T cell expansion in splenic white pulps is accompanied by infiltration of HIV-specific cytotoxic T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Role of antibody-dependent cellular cytotoxicity and lymphokine-activated killer cells in AIDS and related diseases

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

gp120-induced programmed cell death in recently activated T cells without subsequent ligation of the T cell receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

IL-12 inhibits apoptosis induced in a human Th1 clone by gp120/CD4 cross-linking and CD3/TCR activation or by IL-2 deprivation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

T-cell-mediated immunopathology versus direct cytolysis by virus: implications for HIV and AIDS.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

T Cell Telomere Length in HIV-1 Infection: No Evidence for Increased CD4+ T Cell Turnover

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

T helper type 1/T helper type 2 cytokines and T cell death: preventive effect of interleukin 12 on activation-induced and CD95 (FAS/APO-1)-mediated apoptosis of CD4+ T cells from human immunodeficiency virus-infected persons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Tat-expressing Jurkat cells show an increased resistance to different apoptotic stimuli, including acute human immunodeficiency virus-type 1 (HIV-1) infection

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Inhibition of antigen-induced lymphocyte proliferation by Tat protein from HIV-1.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Repression of MHC class I gene promoter activity by two-exon Tat of HIV

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Physical and functional interaction of Nef with Lck. HIV-1 Nef-induced T-cell signaling defects.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

HIV-1 Vpr suppresses immune activation and apoptosis through regulation of nuclear factor kappa B.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400822

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4400822

1 reference

31 July 2017

1 reference

PubMed ID

11313714