Clinical research results with dl1520 (Onyx-015), a replication-selective adenovirus for the treatment of cancer: what have we learned? (Q34225918)

31 July 2017

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title

Clinical research results with dl1520 (Onyx-015), a replication-selective adenovirus for the treatment of cancer: what have we learned? (English)

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31 July 2017

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Kirn D

1

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31 July 2017

1 January 2001

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31 July 2017

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31 July 2017

8

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31 July 2017

2

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31 July 2017

89-98

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https://scigraph.springernature.com/pub.10.1038/sj.gt.3301377

31 July 2017

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cites work

Replication-selective microbiological agents: fighting cancer with targeted germ warfare

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Replication-selective adenoviruses as oncolytic agents

21 January 2018

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Studies on the use of viruses in the treatment of carcinoma of the cervix

21 January 2018

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Treatment of human cancer with mumps virus

21 January 2018

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Experimental Therapy of Human Glioma by Means of a Genetically Engineered Virus Mutant

21 January 2018

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Attenuated multi-mutated herpes simplex virus-1 for the treatment of malignant gliomas

21 January 2018

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An adenovirus mutant that replicates selectively in p53-deficient human tumor cells

21 January 2018

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ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

21 January 2018

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Reovirus therapy of tumors with activated Ras pathway

21 January 2018

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Poxvirus vectors: orphaned and underappreciated

21 January 2018

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Intergeneric poliovirus recombinants for the treatment of malignant glioma

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3301377

Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3301377

Adenovirus proteins that subvert host defenses

21 January 2018

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Efficacy of a replication-competent adenovirus (ONYX-015) following intratumoral injection: intratumoral spread and distribution effects

21 January 2018

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p53 alterations in recurrent squamous cell cancer of the head and neck refractory to radiotherapy

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3301377

The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3301377

p53 mutations in human cancers

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3301377

Hepatic arterial infusion of chemotherapy after resection of hepatic metastases from colorectal cancer

21 January 2018

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a controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301377

Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301377

Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3301377

Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3301377

Nuclear export of the E1B 55-kDa and E4 34-kDa adenoviral oncoproteins mediated by a rev-like signal sequence

21 January 2018

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A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo.

21 January 2018

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A novel three-pronged approach to kill cancer cells selectively: concomitant viral, double suicide gene, and radiotherapy

21 January 2018

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Identification of a conserved receptor-binding site on the fiber proteins of CAR-recognizing adenoviridae

21 January 2018

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Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015).

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3301377

VIRUSES IN THE TREATMENT OF CANCER

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3301377

7 January 2021

Parvovirus H-1 inhibits growth of short-term tumor-derived but not normal mammary tissue cultures

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https://api.crossref.org/works/10.1038%2FSJ.GT.3301377

7 January 2021

p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection

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https://api.crossref.org/works/10.1038%2FSJ.GT.3301377

7 January 2021

The early region 1B 55-kilodalton oncoprotein of adenovirus relieves growth restrictions imposed on viral replication by the cell cycle

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https://api.crossref.org/works/10.1038%2FSJ.GT.3301377

7 January 2021

An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301377

7 January 2021

Lipid A mutant Salmonella with suppressed virulence and TNFalpha induction retain tumor-targeting in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301377

7 January 2021

Identifiers

DOI

10.1038/SJ.GT.3301377

1 reference

31 July 2017

1 reference

PubMed ID

11313778