Do VHL and HIF-1 mirror p53 and Mdm-2? Degradation-transactivation loops of oncoproteins and tumor suppressors (Q34226063)

31 July 2017

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title

Do VHL and HIF-1 mirror p53 and Mdm-2? Degradation-transactivation loops of oncoproteins and tumor suppressors (English)

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31 July 2017

1

M V Blagosklonny

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PubMed ID

11313969

31 July 2017

language of work or name

English

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publication date

1 January 2001

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31 July 2017

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31 July 2017

20

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31 July 2017

3

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31 July 2017

395-398

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1204055

31 July 2017

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cites work

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Regulation of BRCA1 by protein degradation

21 January 2018

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Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53

21 January 2018

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DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

21 January 2018

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Regulation of E2F through ubiquitin-proteasome-dependent degradation: stabilization by the pRB tumor suppressor protein

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Excess beta-catenin promotes accumulation of transcriptionally active p53.

21 January 2018

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Inhibition of transcription elongation by the VHL tumor suppressor protein

21 January 2018

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The complexity of p53 modulation: emerging patterns from divergent signals

21 January 2018

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The hypoxic response: huffing and HIFing

21 January 2018

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Mdm2 promotes the rapid degradation of p53

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204055

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma

21 January 2018

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Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas

21 January 2018

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Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

21 January 2018

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Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

21 January 2018

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Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

21 January 2018

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p53: puzzle and paradigm

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Regulation of p53 stability by Mdm2

21 January 2018

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MDM2--arbiter of p53's destruction

21 January 2018

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Identification of the von Hippel-Lindau disease tumor suppressor gene

21 January 2018

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Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

21 January 2018

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

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p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.

21 January 2018

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The von Hippel-Lindau tumour suppressor protein: new perspectives

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Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

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Amplification of a gene encoding a p53-associated protein in human sarcomas

21 January 2018

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The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal

21 January 2018

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Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein

21 January 2018

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Isolation and characterization of the full-length 3' untranslated region of the human von Hippel-Lindau tumor suppressor gene

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204055

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

21 January 2018

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Expression of hypoxia-inducible factor 1: mechanisms and consequences

21 January 2018

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A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204055

Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204055

Inhibitors of transcription, proteasome inhibitors, and DNA-damaging drugs differentially affect feedback of p53 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204055

inferred from DOI database lookup

7 January 2021

based on heuristic

Tumor induction and tissue atrophy in mice lacking E2F-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204055

inferred from DOI database lookup

7 January 2021

based on heuristic

Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor alpha (RARalpha) and oncogenic RARalpha fusion proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204055

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.ONC.1204055

1 reference

PubMed ID

11313969

Dimensions Publication ID

31 July 2017

0 references

1 reference

PubMed ID

11313969