The importance of drug-transporting P-glycoproteins in toxicology (Q34232320)

31 July 2017

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title

The importance of drug-transporting P-glycoproteins in toxicology (English)

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31 July 2017

van Tellingen O

1

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31 July 2017

1 March 2001

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31 July 2017

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31 July 2017

120

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31 July 2017

1-3

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31 July 2017

31-41

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Unknotting the complexities of multidrug resistance: the involvement of DNA topoisomerases in drug action and resistance.

31 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

New physiological functions for drug-transporting P-glycoproteins?

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Clinical relevance of transmembrane drug efflux as a mechanism of multidrug resistance.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

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https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

In situ biochemical demonstration that P-glycoprotein is a drug efflux pump with broad specificity.

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https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

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https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues

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https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

The biochemistry of P-glycoprotein-mediated multidrug resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Biochemistry of multidrug resistance mediated by the multidrug transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Cloning and characterization of a second member of the mouse mdr gene family

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Multiple physiological functions for multidrug transporter P-glycoprotein?

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Role of blood-brain barrier P-glycoprotein in limiting brain accumulation and sedative side-effects of asimadoline, a peripherally acting analgaesic drug

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell Lines

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https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

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https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Multidrug resistance in leukemia.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

The molecular interaction of the high affinity reversal agent XR9576 with P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Use of fluorescent dyes as molecular probes for the study of multidrug resistance

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https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Physical mapping, amplification, and overexpression of the mouse mdr gene family in multidrug-resistant cells

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https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

The membrane lipid environment modulates drug interactions with the P-glycoprotein multidrug transporter.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Phase I and pharmacokinetic study of paclitaxel in combination with biricodar, a novel agent that reverses multidrug resistance conferred by overexpression of both MDR1 and MRP.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Interaction of bioactive hydrophobic peptides with the human multidrug transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

P-Glycoprotein, a gatekeeper in the blood-brain barrier

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

A general pattern for substrate recognition by P-glycoprotein.

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https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

The P-glycoprotein efflux pump: how does it transport drugs?

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https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Modulation and prevention of multidrug resistance by inhibitors of P-glycoprotein

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https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Contribution of the murine mdr1a P-glycoprotein to hepatobiliary and intestinal elimination of cationic drugs as measured in mice with an mdr1a gene disruption.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Hepatocyte-specific expression of the human MDR3 P-glycoprotein gene restores the biliary phosphatidylcholine excretion absent in Mdr2 (-/-) mice

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

How does P-glycoprotein recognize its substrates?

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Altered pharmacokinetics of vinblastine in Mdr1a P-glycoprotein-deficient Mice

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdr1a P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Tissue disposition, excretion and metabolism of vinblastine in mice as determined by high-performance liquid chromatography

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

Disruption of mdr1a p-glycoprotein gene results in dysfunction of blood-inner ear barrier in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2801%2900304-6

7 January 2021

10.1016/S0378-4274(01)00304-6

Identifiers

DOI

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31 July 2017

1 reference

PubMed ID

11323159