Screening for inhibitors of the SOD1 gene promoter: pyrimethamine does not reduce SOD1 levels in cell and animal models (Q34234969)

31 July 2017

title

Screening for inhibitors of the SOD1 gene promoter: pyrimethamine does not reduce SOD1 levels in cell and animal models (English)

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31 July 2017

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4

Jonathan Matthews

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31 July 2017

7

Robert H Brown

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31 July 2017

Paul D Wright

1

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31 July 2017

Mickey Huang

2

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31 July 2017

Alexandra Weiss

3

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31 July 2017

Nicholas Wightman

5

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31 July 2017

Marcie Glicksman

6

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31 July 2017

language of work or name

English

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publication date

16 July 2010

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31 July 2017

number of pages

5

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inferred from page(s)

published in

Neuroscience Letters

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31 July 2017

volume

482

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31 July 2017

issue

3

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31 July 2017

page(s)

188-192

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Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells

31 July 2017

cites work

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6 July 2018

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Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis

6 July 2018

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Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression

6 July 2018

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TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis

6 July 2018

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Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

6 July 2018

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PTC124 targets genetic disorders caused by nonsense mutations

6 July 2018

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Two approaches to drug discovery in SOD1-mediated ALS.

6 July 2018

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Antisense oligonucleotide therapy for neurodegenerative disease.

6 July 2018

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Onset and progression in inherited ALS determined by motor neurons and microglia

6 July 2018

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Medicinal chemical properties of successful central nervous system drugs

6 July 2018

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Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

6 July 2018

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Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

6 July 2018

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Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS).

6 July 2018

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Pyrimethamine concentrations in serum and cerebrospinal fluid during treatment of acute Toxoplasma encephalitis in patients with AIDS.

6 July 2018

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Triple post-transcriptional control

6 July 2018

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Lipid-soluble inhibitors of dihydrofolate reductase. I. Kinetics, tissue distribution, and extent of metabolism of pyrimethamine, metoprine, and etoprine in the rat, dog, and man

6 July 2018

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Pyrimethamine (2,4-diamino-5-p-chlorophenyl-6-ethylpyrimidine) induces apoptosis of freshly isolated human T lymphocytes, bypassing CD95/Fas molecule but involving its intrinsic pathway

6 July 2018

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Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model

28 October 2018

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Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS.

28 October 2018

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A novel candidate region for ALS on chromosome 14q11.2.

28 October 2018

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28 October 2018

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Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment.

28 October 2018

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Erratum: Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

28 October 2018

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12 December 2020

Plasmodium berghei dihydrofolate reductase. Isolation, properties, and inhibition by antifolates

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12 December 2020

Accumulation of SOD1 mutants in postnatal motoneurons does not cause motoneuron pathology or motoneuron disease

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12 December 2020

Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: associated mutations develop motor neuron disease

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12 December 2020

Restricted expression of G86R Cu/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motoneuron degeneration

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12 December 2020

10.1016/J.NEULET.2010.07.020

Identifiers

DOI

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31 July 2017

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31 July 2017

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