Endomorphin-1 and endomorphin-2: pharmacology of the selective endogenous mu-opioid receptor agonists (Q34241340)

31 July 2017

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title

Endomorphin-1 and endomorphin-2: pharmacology of the selective endogenous mu-opioid receptor agonists (English)

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31 July 2017

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G Horvath

1

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31 July 2017

1 December 2000

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Pharmacology & Therapeutics

31 July 2017

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31 July 2017

88

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31 July 2017

3

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31 July 2017

437-463

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Endomorphins have orexigenic and anxiolytic activities in mice

31 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Maturation of endomorphin-2 in the dorsal horn of the medulla and spinal cord of the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

The ontogeny of endomorphin-1- and endomorphin-2-like immunoreactivity in rat brain and spinal cord

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Peripheral effects of opioid drugs on capsaicin-sensitive neurones of the guinea-pig bronchus and rabbit ear.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Modulation of cholinergic neurotransmission in guinea-pig airways by opioids

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Evidence for kappa- and mu-opioid receptor expression in C6 glioma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Specific G protein activation and mu-opioid receptor internalization caused by morphine, DAMGO and endomorphin I

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Vasodepressor responses to [D-Ala2]-endomorphin 2 (TAPP) are mediated by an L-NAME-sensitive mechanism in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

The endogenous mu-opioid receptor agonists endomorphins 1 and 2 have novel hypotensive activity in the rabbit

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

The endogenous mu-opioid agonists, endomorphin 1 and 2, have vasodilator activity in the hindquarters vascular bed of the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Nitric oxide release mediates vasodilator responses to endomorphin 1 but not nociceptin/OFQ in the hindquarters vascular bed of the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Endomorphin 1 and 2, the endogenous mu-opioid agonists, produce biphasic changes in systemic arterial pressure in the cat.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Endomorphin 1 and 2 have vasodepressor activity in the anesthetized mouse

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https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Endomorphin 1 and 2, endogenous ligands for the mu-opioid receptor, decrease cardiac output, and total peripheral resistance in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Distinct inhibitory effects of spinal endomorphin-1 and endomorphin-2 on evoked dorsal horn neuronal responses in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Opioid receptor-coupled second messenger systems

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Endomorphin-1 and endomorphin-2, endogenous ligands for the mu-opioid receptor, inhibit electrical activity of rat rostral ventrolateral medulla neurons in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Mu-opioid receptor modulation of calcium channel current in periaqueductal grey neurons from C57B16/J mice and mutant mice lacking MOR-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Endomorphin 1 and 2, endogenous mu-opioid agonists, decrease systemic arterial pressure in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Depression of glutamatergic transmission by nociceptin in the neonatal rat hemisected spinal cord preparation in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Preferred conformation of endomorphin-1 in aqueous and membrane-mimetic environments

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Naloxone blocks endomorphin-1 but not endomorphin-2 induced inhibition of tachykinergic contractions of guinea-pig isolated bronchus

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Endomorphins fully activate a cloned human mu opioid receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Isolation of relatively large amounts of endomorphin-1 and endomorphin-2 from human brain cortex

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Endomorphin-1 mediates 2 Hz but not 100 Hz electroacupuncture analgesia in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Lack of cross-tolerance between the antinociceptive effect of intrathecal orphanin FQ and morphine in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Isobolographic analysis of interaction between spinal endomorphin-1, a newly isolated endogenous opioid peptide, and lidocaine in the rat formalin test

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Stimulatory effects of opioids

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

The effects of endomorphin-1 and endomorphin-2 in CHO cells expressing recombinant mu-opioid receptors and SH-SY5Y cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Differential effects of endomorphin-1, endomorphin-2, and Tyr-W-MIF-1 on activation of G-proteins in SH-SY5Y human neuroblastoma membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Pre- and postsynaptic inhibitory actions of methionine-enkephalin on identified bulbospinal neurons of the rat RVL.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Inhibition by nociceptin of neurogenic inflammation and the release of SP and CGRP from sensory nerve terminals

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Endomorphins inhibit high-threshold Ca2+ channel currents in rodent NG108-15 cells overexpressing mu-opioid receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Intraplantar morphine depresses spinal c-Fos expression induced by carrageenin inflammation but not by noxious heat

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Antinociceptive effects of intrathecal endomorphin-1 and -2 in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Endomorphin-1 and endomorphin-2 are partial agonists at the human mu-opioid receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Endomorphin-1 reduces carrageenan-induced fos expression in the rat spinal dorsal horn

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Parallel stimulations of in vitro and in situ [35S]GTPgammaS binding by endomorphin 1 and DAMGO in mouse brains.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Modulation of peripheral inflammation by locally administered endomorphin-1

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Endomorphins decrease heart rate and blood pressure possibly by activating vagal afferents in anesthetized rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

mu Opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethality

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Cardiovascular effects of nociceptin in unanesthetized mice

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Properties of mu 3 opiate alkaloid receptors in macrophages, astrocytes, and HL-60 human promyelocytic leukemia cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Localization of endomorphin-2-like immunoreactivity in the rat medulla and spinal cord

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Endomorphin-2 is an endogenous opioid in primary sensory afferent fibers

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Differential distribution of endomorphin 1- and endomorphin 2-like immunoreactivities in the CNS of the rodent

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Activation and internalization of the mu-opioid receptor by the newly discovered endogenous agonists, endomorphin-1 and endomorphin-2

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

The mu-opioid receptor gene-dose dependent reductions in G-protein activation in the pons/medulla and antinociception induced by endomorphins in mu-opioid receptor knockout mice

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Specific activation of the mu opioid receptor (MOR) by endomorphin 1 and endomorphin 2.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Coupling of the cloned mu-opioid receptor with the omega-conotoxin-sensitive Ca2+ current in NG108-15 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Characterization of endomorphin-1 and -2 on [35S]GTPgammaS binding in the mouse spinal cord.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Absence of G-protein activation by mu-opioid receptor agonists in the spinal cord of mu-opioid receptor knockout mice

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Inhibitory effect of endomorphin-1 and -2 on acetylcholine release from myenteric plexus of guinea pig ileum

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Endogenous opiates: 1997.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

The loss of antinociceptive efficacy of spinal morphine in rats with nerve ligation injury is prevented by reducing spinal afferent drive.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Modulation of acetylcholine release from parasympathetic nerves innervating guinea-pig and human trachea by endomorphin-1 and -2

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Stereochemical requirements for receptor recognition of the mu-opioid peptide endomorphin-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Central and peripheral inhibition of gastrointestinal transit in rats: narcotics differ substantially by acting at either or both levels

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Liquid chromatographic study of the enzymatic degradation of endomorphins, with identification by electrospray ionization mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Endomorphin-1 potentiates HIV-1 expression in human brain cell cultures: implication of an atypical mu-opioid receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Immunoreactivity for endomorphin-2 occurs in primary afferents in rats and monkey

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Conformational analysis of the endogenous mu-opioid agonist endomorphin-1 using NMR spectroscopy and molecular modeling

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Spinal analgesic action of endomorphins in acute, inflammatory and neuropathic pain in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Pain inhibition by endomorphins

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Diprotin A, an inhibitor of dipeptidyl aminopeptidase IV(EC 3.4.14.5) produces naloxone-reversible analgesia in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Differential involvement of mu-opioid receptor subtypes in endomorphin-1- and -2-induced antinociception

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Antisense oligodeoxynucleotide targeting distinct exons of the cloned mu-opioid receptor distinguish between endomorphin-1 and morphine supraspinal antinociception in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Immunofluorescent identification of endomorphin-2-containing nerve fibers and terminals in the rat brain and spinal cord.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Modulation of endomorphin-2-induced analgesia by dipeptidyl peptidase IV.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Endomorphin-stimulated [35S]GTPgammaS binding in rat brain: evidence for partial agonist activity at mu-opioid receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

In vitro binding and signaling profile of the novel mu opioid receptor agonist endomorphin 2 in rat brain membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Expression of delta, kappa and mu human opioid receptors in Escherichia coli and reconstitution of the high-affinity state for agonist with heterotrimeric G proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Opiate-like substances in an invertebrate, an opiate receptor on invertebrate and human immunocytes, and a role in immunosuppression.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Presence of the mu3 opiate receptor in endothelial cells. Coupling to nitric oxide production and vasodilation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Peripheral mechanisms of opioid analgesia

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Spinal analgesic actions of the new endogenous opioid peptides endomorphin-1 and -2.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Antinociceptive effect and enzymatic degradation of endomorphin-1 in newborn rat spinal cord

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Endomorphin-1 and endomorphin-2 activate mu-opioid receptors in myenteric neurons of the guinea-pig small intestine

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Distinct effect of intracerebroventricular and intrathecal injections of nociceptin/orphanin FQ in the rat formalin test.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Effects of orphanin FQ on endomorphin-1 induced analgesia.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Release of endomorphin-2 like substances from the rat spinal cord

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Endomorphin-like immunoreactivity in the rat dorsal horn and inhibition of substantia gelatinosa neurons in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Itch-associated response and antinociception induced by intracisternal endomorphins in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

A topochemical approach to explain morphiceptin bioactivity

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Structure-activity relationships of naturally occurring and synthetic opioid tetrapeptides acting on locus coeruleus neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Involvement of mu-receptor in endogenous opioid peptide-mediated inhibition of acetylcholine release from the rat stomach

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

A potent and selective endogenous agonist for the mu-opiate receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

Mu, delta, and kappa opiate receptor binding of Tyr-MIF-1 and of Tyr-W-MIF-1, its active fragments, and two potent analogs

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900100-5

7 January 2021

10.1016/S0163-7258(00)00100-5

Identifiers

DOI

1 reference

31 July 2017

1 reference

PubMed ID

11337033