[d4U]-spacer-[HI-236] double-drug inhibitors of HIV-1 reverse-transcriptase. (Q34242282)

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7 February 2020

title

[d4U]-spacer-[HI-236] double-drug inhibitors of HIV-1 reverse-transcriptase (English)

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7 February 2020

2

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7 February 2020

Christopher M Bailey

6

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7 February 2020

author name string

Yassir Younis

1

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7 February 2020

Clare I Muhanji

3

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7 February 2020

Ian Hale

4

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7 February 2020

Rajinder Singh

5

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7 February 2020

Todd J Sullivan

7

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7 February 2020

Karen S Anderson

8

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7 February 2020

language of work or name

English

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publication date

11 May 2010

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Bioorganic & Medicinal Chemistry

7 February 2020

published in

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volume

18

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issue

13

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7 February 2020

page(s)

4661-4673

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Twenty-six years of anti-HIV drug discovery: where do we stand and where do we go?

7 February 2020

cites work

1 reference

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6 July 2018

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C-2-aryl O-substituted HI-236 derivatives as non-nucleoside HIV-1 reverse-transcriptase inhibitors

6 July 2018

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Eradication of HIV: current challenges and new directions

6 July 2018

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Synthesis, anti-HIV-1 activity, and modeling studies of N-3 Boc TSAO compound

6 July 2018

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Tetrazolium-based colorimetric assay for the detection of HIV replication inhibitors: revisited 20 years later

6 July 2018

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Synthesis of prodrug-type anti-HIV agents conjugating a REVERSE transcriptase inhibitor to a HIV-1 integrase inhibitor by a spontaneously cleavable linker

6 July 2018

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Rationally designed dual inhibitors of HIV reverse transcriptase and integrase

6 July 2018

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Current developments in the synthesis and biological activity of HIV-1 double-drug inhibitors.

6 July 2018

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[d4U]-butyne-[HI-236] as a non-cleavable, bifunctional NRTI/NNRTI HIV-1 reverse-transcriptase inhibitor

6 July 2018

1 reference

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The Sonogashira reaction: a booming methodology in synthetic organic chemistry.

6 July 2018

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Developing novel nonnucleoside HIV-1 reverse transcriptase inhibitors: beyond the butterfly

6 July 2018

1 reference

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On the attribution and additivity of binding energies

6 July 2018

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The journey towards elucidating the anti-HCMV activity of alkylated bicyclic furano pyrimidines.

6 July 2018

1 reference

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Synthesis, anti-HIV activity, and metabolic stability of new alkenyldiarylmethane HIV-1 non-nucleoside reverse transcriptase inhibitors

6 July 2018

1 reference

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Synthesis and evaluation of double-prodrugs against HIV. Conjugation of D4T with 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442, emivirine)-type reverse transcriptase inhibitors via the SATE prodrug approach.

6 July 2018

1 reference

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Synthesis of 5-alkynylated d4T analogues as potential HIV-1 reverse transcriptase inhibitors.

6 July 2018

1 reference

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New non-nucleoside reverse transcriptase inhibitors (NNRTIs) in development for the treatment of HIV infections

6 July 2018

1 reference

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Hybrids of [TSAO-T]-[foscarnet]: The first conjugate of foscarnet with a non-nucleoside reverse transcriptase inhibitor through a labile covalent ester bond

6 July 2018

1 reference

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Palladium-assisted routes to nucleosides.

6 July 2018

1 reference

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Structure-based drug design of non-nucleoside inhibitors for wild-type and drug-resistant HIV reverse transcriptase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964380

Synthesis and evaluation of "AZT-HEPT", "AZT-pyridinone", and "ddC-HEPT" conjugates as inhibitors of HIV reverse transcriptase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964380

Potential multifunctional inhibitors of HIV-1 reverse transcriptase. Novel [AZT]-[TSAO-T] and [d4T]-[TSAO-T] heterodimers modified in the linker and in the dideoxynucleoside region

6 July 2018

1 reference

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Rational design of N-[2-(2,5-dimethoxyphenylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea (HI-236) as a potent non-nucleoside inhibitor of drug-resistant human immunodeficiency virus

6 July 2018

1 reference

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The presence of substituents on the aryl moiety of the aryl phosphoramidate derivative of d4T enhances anti-HIV efficacy in cell culture: A structure-activity relationship.

6 July 2018

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Imidazo[1,5-b]pyridazine-d4T conjugates: synthesis and anti-human immunodeficiency virus evaluation

6 July 2018

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5-Alkyl-2-[(methylthiomethyl)thio]-6-(benzyl)-pyrimidin-4-(1H)-ones as potent non-nucleoside reverse transcriptase inhibitors of S-DABO series

6 July 2018

1 reference

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Phosphoramidate derivatives of d4T as inhibitors of HIV: the effect of amino acid variation.

6 July 2018

1 reference

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Mechanism of anti-HIV action of masked alaninyl d4T-MP derivatives

6 July 2018

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Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relationship studies of PETT analogs

6 July 2018

1 reference

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Intracellular delivery of bioactive AZT nucleotides by aryl phosphate derivatives of AZT.

6 July 2018

1 reference

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Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors

6 July 2018

1 reference

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Synthesis and anti-HIV activity of [AZT]-[TSAO-T] and [AZT]-[HEPT] dimers as potential multifunctional inhibitors of HIV-1 reverse transcriptase.

6 July 2018

1 reference

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Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors.

6 July 2018

1 reference

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Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1

6 July 2018

1 reference

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Selective antiviral agents. The metabolism of 5-propyl-2'-deoxyuridine and effects on DNA synthesis in herpes simplex virus type 1 infections

6 July 2018

1 reference

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Nucleoside analogues with clinical potential in antivirus chemotherapy. The effect of several thymidine and 2'-deoxycytidine analogue 5'-triphosphates on purified human (alpha, beta) and herpes simplex virus (types 1, 2) DNA polymerases

6 July 2018

1 reference

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Detection, Isolation, and Continuous Production of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and Pre-AIDS

6 July 2018

1 reference

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Metabolism and anti-human immunodeficiency virus-1 activity of 2-halo-2',3'-dideoxyadenosine derivatives

6 July 2018

1 reference

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Infection of HTLV-III/LAV in HTLV-I-carrying cells MT-2 and MT-4 and application in a plaque assay

6 July 2018

1 reference

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Complete nucleotide sequence of the AIDS virus, HTLV-III

6 July 2018

1 reference

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An investigation into the anti-HIV activity of 2',3'-didehydro-2',3'-dideoxyuridine (d4U) and 2',3'-dideoxyuridine (ddU) phosphoramidate 'ProTide' derivatives.

6 July 2018

1 reference

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Characterization of HIV-1 enzyme reverse transcriptase inhibition by the compound 6-chloro-1,4-dihydro-4-oxo-1-(beta-D-ribofuranosyl) quinoline-3-carboxylic acid through kinetic and in silico studies

28 October 2018

1 reference

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Synthesis and anti-HIV activity of some heterodimers [NRTI]-glycyl-succinyl-[trovirdine analogue] of known HIV-1 reverse transcriptase inhibitors

28 October 2018

1 reference

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Synthesis and anti-HIV activity of [d4U]-[trovirdine analogue] and [d4T]-[trovirdine analogue] heterodimers as inhibitors of HIV-1 reverse transcriptase

28 October 2018

1 reference

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Effects of non-nucleoside inhibitors of human immunodeficiency virus type 1 in cell-free recombinant reverse transcriptase assays

28 October 2018

1 reference

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Demethyl analogues of psychoactive methoxyphenalkylamines: synthesis and serotonin receptor affinities.

28 October 2018

1 reference

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T4 positive human neoplastic cell lines susceptible to and permissive for HTLV-III

28 October 2018

1 reference

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Design, synthesis, and anti-HIV activity of 2′,3′-didehydro-2′,3′-dideoxyuridine (d4U), 2′,3′-dideoxyuridine (ddU) phosphoramidate ‘ProTide’ derivatives

28 October 2018

1 reference

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New telluride-mediated elimination for novel synthesis of 2',3'-didehydro-2',3'-dideoxynucleosides

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20605472

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.BMC.2010.05.025

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20605472%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20605472%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

PubMed publication ID

20605472

1 reference