Structural characteristics of the variable regions of immunoglobulin genes encoding a pathogenic autoantibody in murine lupus (Q34243218)

31 July 2017

title

Structural characteristics of the variable regions of immunoglobulin genes encoding a pathogenic autoantibody in murine lupus (English)

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31 July 2017

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1

B P Tsao

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31 July 2017

F M Ebling

2

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31 July 2017

C Roman

3

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31 July 2017

N Panosian-Sahakian

4

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31 July 2017

K Calame

5

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31 July 2017

B H Hahn

6

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31 July 2017

language of work or name

English

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publication date

1 February 1990

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Journal of Clinical Investigation

31 July 2017

published in

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31 July 2017

volume

85

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31 July 2017

issue

2

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31 July 2017

page(s)

530-540

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Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments

31 July 2017

cites work

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6 July 2018

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Comparison of mouse immunoglobulin gamma 2a and gamma 2b chain genes suggests that exons can be exchanged between genes in a multigenic family

6 July 2018

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Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes.

6 July 2018

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Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions

6 July 2018

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Suppression of NZB/NZW murine nephritis by administration of a syngeneic monoclonal antibody to DNA. Possible role of anti-idiotypic antibodies

6 July 2018

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Use of monoclonal antibodies to identify shared idiotypes on human antibodies to native DNA from patients with systemic lupus erythematosus

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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The Relation of Immunoglobulin Class, Pattern of Antinuclear Antibody, and Complement-Fixing Antibodies to DNA in Sera from Patients with Systemic Lupus Erythematosus*

6 July 2018

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Immunological studies concerning the nephritis of systemic lupus erythematosus

6 July 2018

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Functional and pseudogenes are similarly organized and may equally contribute to the extensive antibody diversity of the IgVHII family

6 July 2018

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Genetic elements used for a murine lupus anti-DNA autoantibody are closely related to those for antibodies to exogenous antigens

6 July 2018

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Distinct clonotypes of anti-DNA antibodies in mice with lupus nephritis

6 July 2018

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6 July 2018

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Murine monoclonal anti-DNA antibodies bind directly to glomerular antigens and form immune deposits

6 July 2018

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Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse

6 July 2018

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Altered cell-surface protein(s), crossreactive with DNA, on spleen cells of autoimmune lupic mice

6 July 2018

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DNA antibody idiotypes: a review of their genetic, clinical, and immunopathologic features

6 July 2018

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Idiotypic spreading promotes the production of pathogenic autoantibodies

6 July 2018

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A 16/6 idiotype-positive anti-DNA antibody is encoded by a conserved VH gene with no somatic mutation

6 July 2018

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Induction of a systemic lupus erythematosus-like disease in mice by a common human anti-DNA idiotype

6 July 2018

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The organization of the mouse Igh-V locus. Dispersion, interspersion, and the evolution of VH gene family clusters

6 July 2018

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Molecular characterization of the A/J J558 family of heavy chain variable region gene segments

6 July 2018

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Immunoglobulin kappa light chain variable region gene complex organization and immunoglobulin genes encoding anti-DNA autoantibodies in lupus mice

6 July 2018

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Somatic diversification of the S107 (T15) VH11 germ-line gene that encodes the heavy-chain variable region of antibodies to double-stranded DNA in (NZB x NZW)F1 mice

6 July 2018

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A new murine Ig VH gene family

6 July 2018

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The heavy chain genes of a lupus anti-DNA autoantibody are encoded in the germ line of a nonautoimmune strain of mouse and conserved in strains of mice polymorphic for this gene locus.

6 July 2018

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Relationship of human variable region heavy chain germ-line genes to genes encoding anti-DNA autoantibodies

6 July 2018

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Somatic diversification of S107 from an antiphosphocholine to an anti-DNA autoantibody is due to a single base change in its heavy chain variable region

6 July 2018

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Eleven MRL-lpr/lpr anti-DNA autoantibodies are encoded by genes from four VH gene families: a potentially biased usage of VH genes.

6 July 2018

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One heavy chain variable region gene segment subfamily in the BALB/c mouse contains 500-1000 or more members

6 July 2018

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Genetic basis for expression of the idiotypic network. One unique Ig VH germline gene accounts for the major family of Ab1 and Ab3 (Ab1') antibodies of the GAT system.

6 July 2018

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Ig heavy chain variable region gene complex of lupus mice exhibits normal restriction fragment length polymorphism

6 July 2018

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V genes encoding autoantibodies: molecular and phenotypic characteristics

6 July 2018

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Analysis of variable region genes encoding a human anti-DNA antibody of normal origin. Implications for the molecular basis of human autoimmune responses.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296455

Diversity of Ig V gene segments found in anti-DNA autoantibodies from a single (NZB x NZW)F1 mouse.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296455

Idiotypic characteristics of immunoglobulins associated with systemic lupus erythematosus. Studies of antibodies deposited in glomeruli of humans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296455

The recurrent expression of variable region segments in human IgM anti-DNA autoantibodies.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296455

Different VL and VH germ-line genes are used to produce similar combining sites with specificity for alpha(1----6)dextrans.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296455

The NZB X SWR model of lupus nephritis. I. Cross-reactive idiotypes of monoclonal anti-DNA antibodies in relation to antigenic specificity, charge, and allotype. Identification of interconnected idiotype families inherited from the normal SWR and th

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296455

Nucleotide sequences of five anti-lysozyme monoclonal antibodies

6 July 2018

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Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

6 July 2018

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Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains

6 July 2018

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Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate

6 July 2018

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DNA sequencing with chain-terminating inhibitors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296455

The role of low affinity antibody in immune complex disease. The quantity of anti-DNA antibodies in NZB/W F1 hybrid mice

6 July 2018

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A κ-immunoglobulin gene is formed by site-specific recombination without further somatic mutation

6 July 2018

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The nucleotide sequence of a 5.5-kilobase DNA segment containing the mouse kappa immunoglobulin J and C region genes

6 July 2018

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V region sequences of anti-DNA and anti-RNA autoantibodies from NZB/NZW F1 mice.

28 October 2018

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A murine nephritogenic monoclonal anti-DNA autoantibody binds directly to mouse laminin, the major non-collagenous protein component of the glomerular basement membrane

28 October 2018

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12 December 2020

Molecular and serological diversity of anti-DNA autoantibodies from NZB and (NZB X NZW) F1 mice

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12 December 2020

Murine models of systemic lupus erythematosus

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12 December 2020

Anti-DNA antibodies bind directly to renal antigens and induce kidney dysfunction in the isolated perfused rat kidney

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12 December 2020

The role of anti-idiotypic antibodies in the induction of experimental systemic lupus erythematosus in mice

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12 December 2020

Suppression of murine lupus nephritis by administration of an anti-idiotypic antibody to anti-DNA

1 reference

12 December 2020

The in vivo and in vitro glomerular deposition of isolated anti-double-stranded-DNA antibodies in NZB/W mice

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12 December 2020

Viral transduction of c-myc gene in naturally occurring feline leukaemias

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12 December 2020

A public idiotypic determinant is present on spontaneous cationic IgG antibodies to DNA from mice of unrelated lupus-prone strains

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12 December 2020

The Igh-V locus of MRL mice: restriction fragment length polymorphism in eleven strains of mice as determined with VH and D gene probes

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12 December 2020

Idiotype restriction in murine lupus; high frequency of three public idiotypes on serum IgG in nephritic NZB/NZW F1 mice

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12 December 2020

Polyreactive autoantibodies are nephritogenic in murine lupus nephritis

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12 December 2020

Restricted subpopulations of DNA antibodies in kidneys of mice with systemic lupus. Comparison of antibodies in serum and renal eluates

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12 December 2020

Antigen-binding diversity and idiotypic cross-reactions among hybridoma autoantibodies to DNA

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12 December 2020

A high frequency idiotypic marker of anti-DNA autoantibodies in MRL-Ipr/Ipr mice

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12 December 2020

Characteristics of pathogenic subpopulations of antibodies to DNA

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12 December 2020

Allogeneic MHC antigen requirements for lupus-like autoantibody production and nephritis in murine graft-vs-host disease

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12 December 2020

Identifiers

DOI

10.1172/JCI114469

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31 July 2017

1 reference

31 July 2017

1 reference