Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes (Q34249684)

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English	Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes	scientific article

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scholarly article

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Europe PubMed Central

31 July 2017

Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes (English)

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31 July 2017

Joanna Kowalska

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25150148%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Marcin Ziemniak

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5 June 2020

Maciej Maciejczyk

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5 June 2020

Jacek Jemielity

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5 June 2020

Edward Darżynkiewicz

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Edward Darzynkiewicz

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5 June 2020

Maciej Lukaszewicz

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Maciej Lukaszewicz

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5 June 2020

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Joanna Zuberek

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5 June 2020

Malwina Strenkowska

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Malwina Strenkowska

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5 June 2020

Robert P Rhoads

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Robert E Rhoads

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5 June 2020

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Anna Wypijewska del Nogal

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5 June 2020

Zbigniew M Darzynkiewicz

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5 June 2020

Janina Buck

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5 June 2020

Corina Nicola

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5 June 2020

Andreas N Kuhn

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5 June 2020

Elzbieta Bojarska

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5 June 2020

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22 August 2014

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31 July 2017

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20

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Nucleic Acids Research

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5 June 2020

42

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5 June 2020

10245-10264

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5 June 2020

copyright license

Creative Commons Attribution-NonCommercial 4.0 International

3 May 2017

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April 2022 Public Data File from Crossref

copyright status

0 references

Cap-binding complex (CBC).

1 reference

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6 July 2018

Sp-2-propylthio-ATP-α-B and Sp-2-propylthio-ATP-α-B,β-γ-dichloromethylene are novel potent and specific agonists of the human P2Y₁₁ receptor

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6 July 2018

Potential therapeutic applications of RNA cap analogs.

1 reference

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Magnetic-nanoparticle-decorated polypyrrole microvessels: toward encapsulation of mRNA cap analogues.

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6 July 2018

Inhibition of hepatitis C viral RNA-dependent RNA polymerase by α-P-boranophosphate nucleotides: exploring a potential strategy for mechanism-based HCV drug design

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6 July 2018

Treatment of breast and lung cancer cells with a N-7 benzyl guanosine monophosphate tryptamine phosphoramidate pronucleotide (4Ei-1) results in chemosensitization to gemcitabine and induced eIF4E proteasomal degradation.

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6 July 2018

mRNAs containing the histone 3' stem-loop are degraded primarily by decapping mediated by oligouridylation of the 3' end.

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6 July 2018

Reduction of metal ions by boranephosphonate DNA.

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6 July 2018

7-methylguanosine diphosphate (m(7)GDP) is not hydrolyzed but strongly bound by decapping scavenger (DcpS) enzymes and potently inhibits their activity

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6 July 2018

Structure-guided design, synthesis, and evaluation of guanine-derived inhibitors of the eIF4E mRNA-cap interaction

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6 July 2018

Boranophosphate isoster controls P2Y-receptor subtype selectivity and metabolic stability of dinucleoside polyphosphate analogues

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6 July 2018

Translation, stability, and resistance to decapping of mRNAs containing caps substituted in the triphosphate chain with BH3, Se, and NH

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6 July 2018

Diadenosine 5',5''-(boranated)polyphosphonate analogues as selective nucleotide pyrophosphatase/phosphodiesterase inhibitors

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6 July 2018

Intranodal vaccination with naked antigen-encoding RNA elicits potent prophylactic and therapeutic antitumoral immunity.

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6 July 2018

Towards mRNA with superior translational activity: synthesis and properties of ARCA tetraphosphates with single phosphorothioate modifications

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6 July 2018

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6 July 2018

Synthesis of Boranoate, Selenoate, and Thioate Analogs of AZTp(4)A and Ap(4)A.

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6 July 2018

Efficient overcoming of drug resistance to anticancer nucleoside analogs by nanodelivery of active phosphorylated drugs

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6 July 2018

Structural requirements for Caenorhabditis elegans DcpS substrates based on fluorescence and HPLC enzyme kinetic studies

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6 July 2018

Squalenoyl nucleoside monophosphate nanoassemblies: new prodrug strategy for the delivery of nucleotide analogues

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6 July 2018

Drosophila miR2 primarily targets the m7GpppN cap structure for translational repression

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6 July 2018

Cap in hand: targeting eIF4E.

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6 July 2018

Nontoxic chemical interdiction of the epithelial-to-mesenchymal transition by targeting cap-dependent translation

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6 July 2018

eIF4E: new family members, new binding partners, new roles

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6 July 2018

DcpS as a therapeutic target for spinal muscular atrophy

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6 July 2018

eIF4E, the mRNA cap-binding protein: from basic discovery to translational research

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6 July 2018

Synthesis and characterization of mRNA cap analogs containing phosphorothioate substitutions that bind tightly to eIF4E and are resistant to the decapping pyrophosphatase DcpS

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6 July 2018

Targeting the eukaryotic translation initiation factor 4E for cancer therapy

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6 July 2018

Nucleoside and oligonucleoside boranophosphates: chemistry and properties

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6 July 2018

Synthesis of anti-reverse cap analogs (ARCAs) and their applications in mRNA translation and stability

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6 July 2018

Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity

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6 July 2018

Phosphorothioate cap analogs stabilize mRNA and increase translational efficiency in mammalian cells

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6 July 2018

Diadenosine and diuridine poly(borano)phosphate analogues: synthesis, chemical and enzymatic stability, and activity at P2Y1 and P2Y2 receptors.

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6 July 2018

Differential inhibition of mRNA degradation pathways by novel cap analogs

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6 July 2018

Nematode m7GpppG and m3(2,2,7)GpppG decapping: activities in Ascaris embryos and characterization of C. elegans scavenger DcpS

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6 July 2018

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6 July 2018

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6 July 2018

Molecular recognition in purinergic receptors. 2. Diastereoselectivity of the h-P2Y1-receptor

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6 July 2018

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6 July 2018

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6 July 2018

Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity

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6 July 2018

Novel "anti-reverse" cap analogs with superior translational properties

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6 July 2018

The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases

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6 July 2018

Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins

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6 July 2018

Synthesis and properties of mRNAs containing the novel "anti-reverse" cap analogs 7-methyl(3'-O-methyl)GpppG and 7-methyl (3'-deoxy)GpppG

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6 July 2018

Solid-phase reversible immobilization for the isolation of PCR products

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6 July 2018

Synthetic dinucleotide mRNA cap analogs with tetraphosphate 5',5' bridge containing methylenebis(phosphonate) modification

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21 January 2018

Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo

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21 January 2018

Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation

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21 January 2018

Reading, writing, and modulating genetic information with boranophosphate mimics of nucleotides, DNA, and RNA.

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21 January 2018

Quantitative assessment of mRNA cap analogues as inhibitors of in vitro translation.

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21 January 2018

Analysis of decapping scavenger cap complex using modified cap analogs reveals molecular determinants for efficient cap binding.

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21 January 2018

Influence of electric charge variation at residues 209 and 159 on the interaction of eIF4E with the mRNA 5' terminus

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21 January 2018

P1,P2-diimidazolyl derivatives of pyrophosphate and bis-phosphonates--synthesis, properties, and use in preparation of dinucleoside tetraphosphates and analogs.

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21 January 2018

Synthesis of alpha-P-modified nucleoside diphosphates with ethylenediamine

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21 January 2018

Synthesis of oligo(α-D-glycosyl phosphate) derivatives by a phosphoramidite method via boranophosphate intermediates.

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21 January 2018

Chemical synthesis of diastereomeric diadenosine boranophosphates (ApbA) from 2'-O-(2-cyanoethoxymethyl)adenosine by the boranophosphotriester method.

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21 January 2018

Drug-induced nanocarrier assembly as a strategy for the cellular delivery of nucleotides and nucleotide analogues.

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21 January 2018

Enzymatically stable 5′ mRNA cap analogs: Synthesis and binding studies with human DcpS decapping enzyme

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12 December 2020

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Fluorescence and NMR studies of intramolecular stacking of mRNA cap-analogues

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12 December 2020

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Preparation of synthetically challenging nucleotides using cyanoethyl P-imidazolides and microwaves

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12 December 2020

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Synthesis and properties of mRNA cap analogs containing imidodiphosphate moiety—fairly mimicking natural cap structure, yet resistant to enzymatic hydrolysis

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10.1093/NAR/GKU757

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Europe PubMed Central

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5 June 2020

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Europe PubMed Central

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5 June 2020

1 reference

Europe PubMed Central

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5 June 2020

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