Deficient regulatory T cell activity and low frequency of IL-17-producing T cells correlate with the extent of cardiomyopathy in human Chagas' disease. (Q34251395)

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English	Deficient regulatory T cell activity and low frequency of IL-17-producing T cells correlate with the extent of cardiomyopathy in human Chagas' disease.	scientific article

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30 January 2020

Deficient regulatory T cell activity and low frequency of IL-17-producing T cells correlate with the extent of cardiomyopathy in human Chagas' disease (English)

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Fredy R S Gutierrez

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Paulo Marcos Matta Guedes

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Paulo Marcos Matta Guedes

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Grace Kelly Silva

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Renata Dellalibera-Joviliano

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Gerson Jhonatan Rodrigues

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Lusiane Maria Bendhack

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Anis Rassi

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Anis Rassi

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Benedito Carlos Maciel

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José Antonio Marin Neto

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João Santana Silva

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24 April 2012

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PLoS Neglected Tropical Diseases

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Creative Commons Attribution 4.0 International

24 April 2012

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Regulatory T cells phenotype in different clinical forms of Chagas' disease

1 reference

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6 July 2018

CD4(+)CD25(+)Foxp3(+) regulatory T cells promote Th17 cells in vitro and enhance host resistance in mouse Candida albicans Th17 cell infection model

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6 July 2018

IL-17 produced during Trypanosoma cruzi infection plays a central role in regulating parasite-induced myocarditis

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6 July 2018

IL-17 and IL-22 are associated with protection against human kala azar caused by Leishmania donovani

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6 July 2018

Human regulatory T cells: role in autoimmune disease and therapeutic opportunities

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6 July 2018

Role of Foxp3-positive regulatory T cells during infection

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6 July 2018

The inhibitory cytokine IL-35 contributes to regulatory T-cell function

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6 July 2018

Chagas disease: what is known and what is needed--a background article

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6 July 2018

Regulatory T cells and infection: a dangerous necessity

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6 July 2018

Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation

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6 July 2018

Endogenous CD4(+) CD25(+) regulatory T cells have a limited role in the control of Trypanosoma cruzi infection in mice

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6 July 2018

Are increased frequency of macrophage-like and natural killer (NK) cells, together with high levels of NKT and CD4+CD25high T cells balancing activated CD8+ T cells, the key to control Chagas' disease morbidity?

1 reference

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6 July 2018

Type 1 chemokine receptor expression in Chagas' disease correlates with morbidity in cardiac patients.

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6 July 2018

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

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6 July 2018

Interleukin-17 family members and inflammation

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6 July 2018

IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist

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6 July 2018

Evidence that development of severe cardiomyopathy in human Chagas' disease is due to a Th1-specific immune response

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6 July 2018

Experimental chemotherapy against Trypanosoma cruzi infection: essential role of endogenous interferon-gamma in mediating parasitologic cure

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6 July 2018

Chemokines, inflammation and Trypanosoma cruzi infection.

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6 July 2018

Chronic Chagas' disease cardiomyopathy patients display an increased IFN-gamma response to Trypanosoma cruzi infection.

1 reference

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6 July 2018

The role of the immune response on the development of severe clinical forms of human Chagas disease

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6 July 2018

Characterization of cytokine production in murine Trypanosoma cruzi infection by in situ immunocytochemistry: lack of association between susceptibility and type 2 cytokine production.

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21 January 2018

IFN-gamma in human Chagas' disease: protection or pathology?

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21 January 2018

Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10.

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21 January 2018

IL-17 is necessary for host protection against acute-phase Trypanosoma cruzi infection

1 reference

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21 January 2018

Foxp3(+) regulatory T cells promote T helper 17 cell development in vivo through regulation of interleukin-2.

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21 January 2018

Cutting edge: Foxp3+CD4+CD25+ regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6.

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21 January 2018

Immunological imbalance between IFN-gamma and IL-10 levels in the sera of patients with the cardiac form of Chagas disease.

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21 January 2018

Frequency of interferon- gamma -producing T cells specific for Trypanosoma cruzi inversely correlates with disease severity in chronic human Chagas disease

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21 January 2018

The involvement of CD4+CD25+ T cells in the acute phase of Trypanosoma cruzi infection.

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21 January 2018

Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy

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21 January 2018

Cyclic AMP decreases the production of NO and CCL2 by macrophages stimulated with Trypanosoma cruzi GPI-mucins

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21 January 2018

Beneficial effects of benznidazole during an infectious-based situation of systemic inflammatory response: cecal ligation and puncture.

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28 October 2018

Andean subregional Chagas disease area and the Andean initiative of Chagas disease.

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28 October 2018

Potential role of CD4+CD25HIGH regulatory T cells in morbidity in Chagas disease

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28 October 2018

Chagasic patients develop a type 1 immune response to Trypanosoma cruzi trans-sialidase

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21 January 2018

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9 December 2018

The regulatory CD4+CD25+ T cells have a limited role on pathogenesis of infection with Trypanosoma cruzi

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21 January 2018

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9 December 2018

IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance

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21 January 2018

Chagasic patients with indeterminate clinical form of the disease have high frequencies of circulating CD3+CD16-CD56+ natural killer T cells and CD4+CD25High regulatory T lymphocytes

1 reference

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9 December 2018

[Patients suffering dilated chagasic cardiopathy or non chagasic cardiopathy show an increased levels of tumor necrosis factor alpha]

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9 December 2018

Increased plasma levels of tumor necrosis factor-alpha in asymptomatic/"indeterminate" and Chagas disease cardiomyopathy patients

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9 December 2018

Cytokine mRNA profile of peripheral blood mononuclear cells isolated from individuals with Trypanosoma cruzi chronic infection

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9 December 2018

Antibodies to Trypanosoma cruzi express idiotypic patterns that can differentiate between patients with asymptomatic or severe Chagas' disease

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9 December 2018

Cardiac troponin T in patients with clinically suspected myocarditis

1 reference

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12 December 2020

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10.1371/JOURNAL.PNTD.0001630

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30 January 2020

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