Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance (Q34261616)

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English	Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance	scientific article

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12 March 2020

Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance (English)

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12 March 2020

Andrew D. Mesecar

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12 March 2020

Katrina Sleeman

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Katrina Sleeman

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12 March 2020

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Susan C Baker

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Amornrat O'Brien

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Xufang Deng

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Bridget S Banach

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Bridget S Banach

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12 March 2020

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Sarah E StJohn

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12 March 2020

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Heather L Osswald

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12 March 2020

Arun K Ghosh

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12 March 2020

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6 August 2014

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12 March 2020

Journal of Virology

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12 March 2020

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12 March 2020

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12 March 2020

11886-11898

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12 March 2020

Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection

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Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture

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Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses

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ABT-450/r-ombitasvir and dasabuvir with or without ribavirin for HCV.

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Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection

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Nidovirus papain-like proteases: multifunctional enzymes with protease, deubiquitinating and deISGylating activities

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Influenza A(H7N9) virus gains neuraminidase inhibitor resistance without loss of in vivo virulence or transmissibility.

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6 July 2018

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Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding

1 reference

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6 July 2018

Recent trends in HIV-1 drug resistance

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6 July 2018

Assessing activity and inhibition of Middle East respiratory syndrome coronavirus papain-like and 3C-like proteases using luciferase-based biosensors

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6 July 2018

Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group

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6 July 2018

Molecular basis of human immunodeficiency virus type 1 drug resistance: overview and recent developments.

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6 July 2018

Discovery, synthesis, and structure-based optimization of a series of N-(tert-butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus [...]

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6 July 2018

Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases

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Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia

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6 July 2018

Foldon unfolding mediates the interconversion between M(pro)-C monomer and 3D domain-swapped dimer

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6 July 2018

The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors

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6 July 2018

Recent development of 3C and 3CL protease inhibitors for anti-coronavirus and anti-picornavirus drug discovery

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6 July 2018

Activation and maturation of SARS-CoV main protease

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6 July 2018

Hepatitis C virus resistance to protease inhibitors

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6 July 2018

Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding

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6 July 2018

Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and management

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6 July 2018

Severe Acute Respiratory Syndrome Coronavirus Papain-like Novel Protease Inhibitors: Design, Synthesis, Protein−Ligand X-ray Structure and Biological Evaluation

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6 July 2018

Rapid emergence of protease inhibitor resistance in hepatitis C virus

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6 July 2018

Viral resistance to specifically targeted antiviral therapies for hepatitis C (STAT-Cs).

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6 July 2018

A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication

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6 July 2018

Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors

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Structures of Two Coronavirus Main Proteases: Implications for Substrate Binding and Antiviral Drug Design

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Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors

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6 July 2018

Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain

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RNA replication of mouse hepatitis virus takes place at double-membrane vesicles

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Virus-encoded proteinases and proteolytic processing in the Nidovirales.

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6 July 2018

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Morphogenesis of Avian Infectious Bronchitis Virus and a Related Human Virus (Strain 229E)

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6 July 2018

Replication and plaque formation of mouse hepatitis virus (MHV-2) in mouse cell line DBT culture.

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Severe acute respiratory syndrome

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28 October 2018

A prospective hospital-based study of the clinical impact of non-severe acute respiratory syndrome (Non-SARS)-related human coronavirus infection

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12 December 2020

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First confirmed cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in the United States, updated information on the epidemiology of MERS-CoV infection, and guidance for the public, clinicians, and public health authorities -

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https://pubmed.ncbi.nlm.nih.gov/25100843

12 December 2020

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10.1128/JVI.01528-14

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Europe PubMed Central

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12 March 2020

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12 March 2020

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Europe PubMed Central

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12 March 2020

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