CD4-Pseudomonas exotoxin conjugates delay but do not fully inhibit human immunodeficiency virus replication in lymphocytes in vitro (Q34263852)

1 August 2017

title

CD4-Pseudomonas exotoxin conjugates delay but do not fully inhibit human immunodeficiency virus replication in lymphocytes in vitro (English)

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1 August 2017

6

N L Letvin

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1 August 2017

H Tsubota

1

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1 August 2017

G Winkler

2

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1 August 2017

H M Meade

3

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1 August 2017

A Jakubowski

4

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1 August 2017

D W Thomas

5

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1 August 2017

language of work or name

English

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publication date

1 November 1990

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Journal of Clinical Investigation

1 August 2017

published in

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1 August 2017

volume

86

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1 August 2017

issue

5

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1 August 2017

page(s)

1684-1689

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Cloning, nucleotide sequence, and expression in Escherichia coli of the exotoxin A structural gene of Pseudomonas aeruginosa

1 August 2017

cites work

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The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

6 July 2018

1 reference

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T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV

6 July 2018

1 reference

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A soluble form of CD4 (T4) protein inhibits AIDS virus infection

6 July 2018

1 reference

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Isolation of T-cell tropic HTLV-III-like retrovirus from macaques

6 July 2018

1 reference

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Functional domains of Pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296920

The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296920

Binding of HTLV-III/LAV to T4+ T cells by a complex of the 110K viral protein and the T4 molecule

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296920

The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family.

6 July 2018

1 reference

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Suppression of simian immunodeficiency virus replication in vitro by CD8+ lymphocytes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296920

HIV-infected cells are killed by rCD4-ricin A chain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296920

Soluble CD4 molecules neutralize human immunodeficiency virus type 1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296920

HIV infection is blocked in vitro by recombinant soluble CD4.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296920

Effect of recombinant soluble CD4 in rhesus monkeys infected with simian immunodeficiency virus of macaques

6 July 2018

1 reference

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Pseudomonas exotoxin: chimeric toxins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296920

CD4-Pseudomonas exotoxin hybrid protein blocks the spread of human immunodeficiency virus infection in vitro and is active against cells expressing the envelope glycoproteins from diverse primate immunodeficiency retroviruses

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296920

The safety and pharmacokinetics of recombinant soluble CD4 (rCD4) in subjects with the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. A phase 1 study.

6 July 2018

1 reference

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Recombinant soluble CD4 therapy in patients with the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. A phase I-II escalating dosage trial

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296920

"Panning" for lymphocytes: a method for cell selection

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296920

Blocking of HIV-1 infectivity by a soluble, secreted form of the CD4 antigen

6 July 2018

1 reference

12 December 2020

A soluble CD4 protein selectively inhibits HIV replication and syncytium formation

1 reference

12 December 2020

Selective killing of HIV-infected cells by recombinant human CD4-Pseudomonas exotoxin hybrid protein

1 reference

12 December 2020

Corrected CD4 sequence

1 reference

12 December 2020

In vivo administration of lymphocyte-specific monoclonal antibodies in nonhuman primates. V. Evidence that humoral immune response to monoclonal antibodies and immunotoxin conjugates abrogates their cytotoxic activity

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI114892

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1 August 2017

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1 August 2017

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