Identification of HIV-1 inhibitors targeting the nucleocapsid protein. (Q34269543)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22587465%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

title

Identification of HIV-1 inhibitors targeting the nucleocapsid protein (English)

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1 February 2020

0 references

1 reference

2

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1 February 2020

author name string

Sebastian Breuer

series ordinal

1

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1 February 2020

Jinyun Yuan

series ordinal

3

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1 February 2020

Bruce E Torbett

series ordinal

4

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1 February 2020

language of work or name

English

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publication date

24 May 2012

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Journal of Medicinal Chemistry

1 February 2020

published in

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1 February 2020

volume

55

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1 February 2020

issue

11

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1 February 2020

page(s)

4968-4977

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The relationship between HIV-1 genome RNA dimerization, virion maturation and infectivity

1 February 2020

cites work

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Properties and functions of the nucleocapsid protein in virus assembly

6 July 2018

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Small-molecule inactivation of HIV-1 NCp7 by repetitive intracellular acyl transfer

6 July 2018

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New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

6 July 2018

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Imaging the interaction of HIV-1 genomes and Gag during assembly of individual viral particles

6 July 2018

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Identification of specific small molecule ligands for stem loop 3 ribonucleic acid of the packaging signal Psi of human immunodeficiency virus-1.

6 July 2018

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Identification by high throughput screening of small compounds inhibiting the nucleic acid destabilization activity of the HIV-1 nucleocapsid protein

6 July 2018

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A general method for discovering inhibitors of protein-DNA interactions using photonic crystal biosensors

6 July 2018

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Targeting the viral nucleocapsid protein in anti-HIV-1 therapy.

6 July 2018

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Inhibition of HIV-1 by a peptide ligand of the genomic RNA packaging signal Psi

6 July 2018

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Properties, functions, and drug targeting of the multifunctional nucleocapsid protein of the human immunodeficiency virus.

6 July 2018

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Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination

6 July 2018

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Single DNA molecule stretching measures the activity of chemicals that target the HIV-1 nucleocapsid protein.

6 July 2018

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Single point mutations in the zinc finger motifs of the human immunodeficiency virus type 1 nucleocapsid alter RNA binding specificities of the gag protein and enhance packaging and infectivity

6 July 2018

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Studies on the mechanism of inactivation of the HIV-1 nucleocapsid protein NCp7 with 2-mercaptobenzamide thioesters.

6 July 2018

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The next generation of HIV/AIDS drugs: novel and developmental antiHIV drugs and targets

6 July 2018

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PA-457: A potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing

6 July 2018

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Characterization of a putative alpha-helix across the capsid-SP1 boundary that is critical for the multimerization of human immunodeficiency virus type 1 gag.

6 July 2018

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Proline residues within spacer peptide p1 are important for human immunodeficiency virus type 1 infectivity, protein processing, and genomic RNA dimer stability

6 July 2018

1 reference

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Identification of HIV-1 nucleocapsid protein: nucleic acid antagonists with cellular anti-HIV activity

6 July 2018

1 reference

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A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

6 July 2018

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RNA is a structural element in retrovirus particles

6 July 2018

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NMR structure of the HIV-1 nucleocapsid protein bound to stem-loop SL2 of the psi-RNA packaging signal. Implications for genome recognition

6 July 2018

1 reference

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NMR structure of stem-loop SL2 of the HIV-1 psi RNA packaging signal reveals a novel A-U-A base-triple platform

6 July 2018

1 reference

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

6 July 2018

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A mimic of HIV-1 nucleocapsid protein impairs reverse transcription and displays antiviral activity

6 July 2018

1 reference

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The human immunodeficiency virus type 1 Gag polyprotein has nucleic acid chaperone activity: possible role in dimerization of genomic RNA and placement of tRNA on the primer binding site

6 July 2018

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Nucleomimetic strategy for the inhibition of HIV-1 nucleocapsid protein NCp7 activities

6 July 2018

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Chemical inactivation of retroviral infectivity by targeting nucleocapsid protein zinc fingers: a candidate SIV vaccine.

6 July 2018

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A novel one-step, highly sensitive fluorometric assay to evaluate cell-mediated cytotoxicity

6 July 2018

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Structure of the HIV-1 nucleocapsid protein bound to the SL3 psi-RNA recognition element

6 July 2018

1 reference

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HIV-1 nucleocapsid protein induces "maturation" of dimeric retroviral RNA in vitro

6 July 2018

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Partial inhibition of the human immunodeficiency virus type 1 protease results in aberrant virus assembly and the formation of noninfectious particles.

6 July 2018

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Inhibitors of HIV nucleocapsid protein zinc fingers as candidates for the treatment of AIDS.

6 July 2018

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6 July 2018

Retroviral RNA packaging

1 reference

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A cleavage enzyme-cytometric bead array provides biochemical profiling of resistance mutations in HIV-1 Gag and protease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3499629

In vitro identification and characterization of an early complex linking HIV-1 genomic RNA recognition and Pr55Gag multimerization

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3499629

Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3499629

A Tryptophan-Rich Hexapeptide Inhibits Nucleic Acid Destabilization Chaperoned by the HIV-1 Nucleocapsid Protein†

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3499629

Specificity of acyl transfer from 2-mercaptobenzamide thioesters to the HIV-1 nucleocapsid protein

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22587465

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Real experiences of uHTS: a prototypic 1536-well fluorescence anisotropy-based uHTS screen and application of well-level quality control procedures

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22587465

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Probing the topography of HIV-1 nucleocapsid protein with the alkylating agent N-ethylmaleimide

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22587465

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/JM201442T

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22587465%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22587465%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

PubMed publication ID

22587465

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22587465%20AND%20SRC:MED&resulttype=core&format=json