Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development. (Q34274334)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22579044%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

title

Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development (English)

1 reference

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1 February 2020

16

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1 February 2020

Martin A.M. Reijns

1

1 reference

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1 February 2020

Rachel E Rigby

3

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1 February 2020

Pleasantine Mill

4

1 reference

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1 February 2020

Ian Holt

14

1 reference

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1 February 2020

Andrew Jackson

19

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1 February 2020

author name string

Björn Rabe

2

1 reference

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1 February 2020

Katy R Astell

5

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1 February 2020

Laura A Lettice

6

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1 February 2020

Shelagh Boyle

7

1 reference

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1 February 2020

Andrea Leitch

8

1 reference

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1 February 2020

Margaret Keighren

9

1 reference

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1 February 2020

Fiona Kilanowski

10

1 reference

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1 February 2020

Paul S Devenney

11

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1 February 2020

David Sexton

12

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1 February 2020

Graeme Grimes

13

1 reference

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1 February 2020

Robert E Hill

15

1 reference

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1 February 2020

Kirstie A Lawson

17

1 reference

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1 February 2020

Julia R Dorin

18

1 reference

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1 February 2020

language of work or name

English

0 references

publication date

10 May 2012

1 reference

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1 February 2020

1 reference

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1 February 2020

volume

149

1 reference

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1 February 2020

issue

5

1 reference

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1 February 2020

page(s)

1008-1022

1 reference

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describes a project that uses

1 February 2020

limma

object named as

Limma

2 references

22 June 2022

https://europepmc.org/article/PMC/3383994

inferred from PubMed Central ID database lookup

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

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The major roles of DNA polymerases epsilon and delta at the eukaryotic replication fork are evolutionarily conserved

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6 July 2018

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Replication of ribonucleotide-containing DNA templates by yeast replicative polymerases

6 July 2018

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Mutagenic processing of ribonucleotides in DNA by yeast topoisomerase I

6 July 2018

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The RNA worlds in context

6 July 2018

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Loss of p53 partially rescues embryonic development of Palb2 knockout mice but does not foster haploinsufficiency of Palb2 in tumour suppression

6 July 2018

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PCNA directs type 2 RNase H activity on DNA replication and repair substrates

6 July 2018

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The structural and biochemical characterization of human RNase H2 complex reveals the molecular basis for substrate recognition and Aicardi-Goutières syndrome defects

6 July 2018

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The Structure of the Human RNase H2 Complex Defines Key Interaction Interfaces Relevant to Enzyme Function and Human Disease

6 July 2018

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The DNA Damage Response: Making It Safe to Play with Knives

6 July 2018

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Genome instability due to ribonucleotide incorporation into DNA.

6 July 2018

1 reference

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Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis

6 July 2018

1 reference

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DNA polymerase beta ribonucleotide discrimination: insertion, misinsertion, extension, and coding.

6 July 2018

1 reference

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The origins and evolution of the p53 family of genes

6 July 2018

1 reference

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Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases

6 July 2018

1 reference

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Mammalian mitochondrial DNA replication intermediates are essentially duplex but contain extensive tracts of RNA/DNA hybrid

6 July 2018

1 reference

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Expanding the phenotypic spectrum of lupus erythematosus in Aicardi-Goutières syndrome

6 July 2018

1 reference

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Multiple roles of the cell cycle inhibitor p21(CDKN1A) in the DNA damage response.

6 July 2018

1 reference

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Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin.

6 July 2018

1 reference

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The Structure of the Mammalian RNase H2 Complex Provides Insight into RNA⋅DNA Hybrid Processing to Prevent Immune Dysfunction

6 July 2018

1 reference

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Aicardi-Goutieres syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunity

6 July 2018

1 reference

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Mitochondrial DNA replication and repair: all a flap

6 July 2018

1 reference

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Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

6 July 2018

1 reference

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Ribonuclease H: the enzymes in eukaryotes

6 July 2018

1 reference

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Contributions of the two accessory subunits, RNASEH2B and RNASEH2C, to the activity and properties of the human RNase H2 complex

6 July 2018

1 reference

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Polymerase dynamics at the eukaryotic DNA replication fork

6 July 2018

1 reference

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Dividing the workload at a eukaryotic replication fork

6 July 2018

1 reference

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Trex1 prevents cell-intrinsic initiation of autoimmunity

6 July 2018

1 reference

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Single-strand break repair and genetic disease

6 July 2018

1 reference

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Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease

6 July 2018

1 reference

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EUCOMM--the European conditional mouse mutagenesis program.

6 July 2018

1 reference

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Structure of human RNase H1 complexed with an RNA/DNA hybrid: insight into HIV reverse transcription

6 July 2018

1 reference

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Clinical and molecular phenotype of Aicardi-Goutieres syndrome

6 July 2018

1 reference

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beadarray: R classes and methods for Illumina bead-based data.

6 July 2018

1 reference

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A role for Xrcc2 in the early stages of mouse development

6 July 2018

1 reference

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ATR-dependent phosphorylation of DNA-dependent protein kinase catalytic subunit in response to UV-induced replication stress

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

Reconstituted Okazaki fragment processing indicates two pathways of primer removal

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

Linear models and empirical bayes methods for assessing differential expression in microarray experiments

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

Telomerase limits the extent of base pairing between template RNA and telomeric DNA.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

RNase-sensitive DNA modification(s) initiates S. pombe mating-type switching

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

RNase H2 of Saccharomyces cerevisiae is a complex of three proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

Cotranscriptionally Formed DNA:RNA Hybrids Mediate Transcription Elongation Impairment and Transcription-Associated Recombination

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

Mitochondrial DNA replication: what we know

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

Repair of endogenous DNA damage

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

What do human micronuclei contain?

6 July 2018

1 reference

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Failure to produce mitochondrial DNA results in embryonic lethality in Rnaseh1 null mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

Excision of misincorporated ribonucleotides in DNA by RNase H (type 2) and FEN-1 in cell-free extracts

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

Initial sequencing and comparative analysis of the mouse genome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

The absence of ribonuclease H1 or H2 alters the sensitivity of Saccharomyces cerevisiae to hydroxyurea, caffeine and ethyl methanesulphonate: implications for roles of RNases H in DNA replication and repair

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

A role for ATR in the DNA damage-induced phosphorylation of p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

Site-specific ribonuclease activity of eukaryotic DNA topoisomerase I.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

Choosing the right sugar: how polymerases select a nucleotide substrate

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

Characterization of the unusually rapid cell cycles during rat gastrulation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

Mouse centromere mapping using oligonucleotide probes that detect variants of the minor satellite.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

Enzymatic completion of mammalian lagging-strand DNA replication

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

Purification, subunit structure, and serologicai analysis of calf thymus ribonuclease H I

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

Enzyme from calf thymus degrading the RNA moiety of DNA-RNA Hybrids: effect on DNA-dependent RNA polymerase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

The presence of ribonucleotides in mature closed-circular mitochondrial DNA.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

Discontinuous DNA synthesis by purified mammalian proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

Role of poly(ADP-ribose) formation in DNA repair

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

Mouse L cell mitochondrial DNA molecules are selected randomly for replication throughout the cell cycle

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

Discontinuous replication of replicative form DNA from bacteriophage phiX174

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

Nuclear reorganisation and chromatin decondensation are conserved, but distinct, mechanisms linked to Hox gene activation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

The wild-type Schizosaccharomyces pombe mat1 imprint consists of two ribonucleotides

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

A reliable lacZ expression reporter cassette for multipurpose, knockout-first alleles.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

Cyclin G1 is involved in G2/M arrest in response to DNA damage and in growth control after damage recovery.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

Disruption of the Rev3l-encoded catalytic subunit of polymerase zeta in mice results in early embryonic lethality.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

Disruption of the developmentally regulated Rev3l gene causes embryonic lethality.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

Thymocyte apoptosis induced by p53-dependent and independent pathways.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

High-frequency developmental abnormalities in p53-deficient mice.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

Kinetic analysis of Escherichia coli RNase H using DNA-RNA-DNA/DNA substrates

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383994

Quantification of aminofluorene adduct formation and repair in defined DNA sequences in mammalian cells using the UVRABC nuclease

28 October 2018

1 reference

12 December 2020

A subset of p53-deficient embryos exhibit exencephaly

1 reference

12 December 2020

Substrate specificity of human RNase H1 and its role in excision repair of ribose residues misincorporated in DNA

1 reference

12 December 2020

Linking retroelements to autoimmunity

1 reference

12 December 2020

Creation and removal of embedded ribonucleotides in chromosomal DNA during mammalian Okazaki fragment processing

1 reference

12 December 2020

10.1016/J.CELL.2012.04.011

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22579044%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22579044%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22579044%20AND%20SRC:MED&resulttype=core&format=json