Cadmium impairs albumin reabsorption by down-regulating megalin and ClC5 channels in renal proximal tubule cells. (Q34282828)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20576581%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

title

Cadmium impairs albumin reabsorption by down-regulating megalin and ClC5 channels in renal proximal tubule cells (English)

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6 February 2020

1 reference

2

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6 February 2020

3

William B Guggino

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6 February 2020

author name string

Patrizia Gena

series ordinal

1

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6 February 2020

publication date

1 November 2010

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Environmental Health Perspectives

6 February 2020

published in

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6 February 2020

volume

118

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6 February 2020

issue

11

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6 February 2020

page(s)

1551-1556

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Cadmium: cellular effects, modifications of biomolecules, modulation of DNA repair and genotoxic consequences (a review).

6 February 2020

cites work

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Cadmium induces the expression of Grp78, an endoplasmic reticulum molecular chaperone, in LLC-PK1 renal epithelial cells

6 July 2018

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ClC-5: a chloride channel with multiple roles in renal tubular albumin uptake.

6 July 2018

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Chloride/proton antiporter activity of mammalian CLC proteins ClC-4 and ClC-5.

6 July 2018

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Apoptosis induced by cadmium

6 July 2018

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Molecular and cellular mechanisms of cadmium carcinogenesis

6 July 2018

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6 July 2018

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Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules

6 July 2018

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6 July 2018

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Sensitive endpoints for evaluating cadmium-induced acute toxicity in LLC-PK1 cells.

6 July 2018

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Physiological importance of endosomal acidification: potential role in proximal tubulopathies

6 July 2018

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The tandem endocytic receptors megalin and cubilin are important proteins in renal pathology.

6 July 2018

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Molecular structure and physiological function of chloride channels

6 July 2018

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Cadmium overload and toxicity

6 July 2018

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Aristolochic acid impedes endocytosis and induces DNA adducts in proximal tubule cells

6 July 2018

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Use of flow cytometry and confocal microscopy techniques to investigate early CdCl(2)-induced nephrotoxicity in vitro

6 July 2018

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Megalin and cubilin: synergistic endocytic receptors in renal proximal tubule

6 July 2018

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Cadmium inhibits albumin endocytosis in opossum kidney epithelial cells

6 July 2018

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CLC chloride channels in Caenorhabditis elegans

6 July 2018

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Megalin knockout mice as an animal model of low molecular weight proteinuria.

6 July 2018

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Cadmium-mediated oxidative stress in kidney proximal tubule cells induces degradation of Na+/K(+)-ATPase through proteasomal and endo-/lysosomal proteolytic pathways

6 July 2018

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Intra-renal and subcellular distribution of the human chloride channel, CLC-5, reveals a pathophysiological basis for Dent's disease

6 July 2018

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Protein trafficking and polarity in kidney epithelium: from cell biology to physiology

6 July 2018

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Comparison of the cytotoxic effects of cadmium chloride and cadmium-metallothionein in LLC-PK1 cells

6 July 2018

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Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

6 July 2018

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Nephrotoxicity of CdCl2 and Cd-metallothionein in cultured rat kidney proximal tubules and LLC-PK1 cells

6 July 2018

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Oxidative mechanisms in the toxicity of metal ions

6 July 2018

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Isolation and characterization of the apical surface of polarized Madin-Darby canine kidney epithelial cells

6 July 2018

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ClC-5: role in endocytosis in the proximal tubule.

6 July 2018

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Inhibition of renal Na+/H+ exchange in cadmium-intoxicated rats

28 October 2018

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28 October 2018

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Mice lacking renal chloride channel, CLC-5, are a model for Dent's disease, a nephrolithiasis disorder associated with defective receptor-mediated endocytosis.

28 October 2018

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ClC-5 Cl- -channel disruption impairs endocytosis in a mouse model for Dent's disease.

28 October 2018

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Cadmium inhibits vacuolar H(+)-ATPase and endocytosis in rat kidney cortex.

28 October 2018

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Cadmium uptake by primary cultures of rat renal cortical epithelial cells: influence of cell density and other metal ions.

28 October 2018

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Endocytosis in proximal tubule cells involves a two-phase membrane-recycling pathway

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20576581

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20576581

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cd-MT causes endocytosis of brush-border transporters in rat renal proximal tubules

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20576581

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1289/EHP.0901874

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20576581%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20576581%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference