Monovalency unleashes the full therapeutic potential of the DN-30 anti-Met antibody (Q34285473)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20833723%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

title

Monovalency unleashes the full therapeutic potential of the DN-30 anti-Met antibody (English)

1 reference

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13 February 2020

1 reference

5

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13 February 2020

Paolo M. Comoglio

8

1 reference

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13 February 2020

Elisa Vigna

10

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13 February 2020

1

Giovanni Pacchiana

1 reference

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13 February 2020

2

Cristina Chiriaco

1 reference

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13 February 2020

4

Fiorella Petronzelli

1 reference

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13 February 2020

9

Paolo Michieli

1 reference

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13 February 2020

author name string

Maria C Stella

3

1 reference

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13 February 2020

Maria Galluzzo

6

1 reference

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13 February 2020

Paolo Carminati

7

1 reference

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13 February 2020

language of work or name

English

0 references

publication date

10 September 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20833723%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

13 February 2020

published in

1 reference

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13 February 2020

volume

285

1 reference

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13 February 2020

issue

46

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13 February 2020

page(s)

36149-36157

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Down-regulation of the met receptor tyrosine kinase by presenilin-dependent regulated intramembrane proteolysis

13 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975237

"Active" cancer immunotherapy by anti-Met antibody gene transfer

6 July 2018

1 reference

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When binding is enough: nonactivating antibody formats.

6 July 2018

1 reference

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Drug development of MET inhibitors: targeting oncogene addiction and expedience

6 July 2018

1 reference

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Albinterferon alpha-2b: a genetic fusion protein for the treatment of chronic hepatitis C.

6 July 2018

1 reference

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c-Met is essential for wound healing in the skin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975237

Lung cancer cell lines harboring MET gene amplification are dependent on Met for growth and survival

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975237

Invasive growth: a MET-driven genetic programme for cancer and stem cells

6 July 2018

1 reference

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Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity

6 July 2018

1 reference

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Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975237

Agonist Met antibodies define the signalling threshold required for a full mitogenic and invasive program of Kaposi's Sarcoma cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975237

High-throughput antibody production

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975237

Targeting the tumor and its microenvironment by a dual-function decoy Met receptor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975237

Met provides essential signals for liver regeneration

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975237

Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975237

Met, metastasis, motility and more

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975237

PEGylated antibodies and antibody fragments for improved therapy: a review

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975237

Scatter-factor and semaphorin receptors: cell signalling for invasive growth

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975237

An HGF-MSP chimera disassociates the trophic properties of scatter factors from their pro-invasive activity.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975237

Invasive growth: from development to metastasis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975237

Hepatocyte growth factor enhances vascular endothelial growth factor-induced angiogenesis in vitro and in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975237

Sustained survival of human hepatocytes in mice: A model for in vivo infection with human hepatitis B and hepatitis delta viruses.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975237

Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975237

Agonistic monoclonal antibodies against the Met receptor dissect the biological responses to HGF.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975237

Tyrosines1234-1235 are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor).

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975237

p145, a protein with associated tyrosine kinase activity in a human gastric carcinoma cell line

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975237

Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975237

Albumin binding as a general strategy for improving the pharmacokinetics of proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975237

Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2975237

Monoclonal antibody therapy of cancer

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20833723

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A novel tri-functional antibody fusion protein with improved pharmacokinetic properties generated by fusing a bispecific single-chain diabody with an albumin-binding domain from streptococcal protein G

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20833723

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M110.134031

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20833723%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20833723%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

PubMed publication ID

20833723

1 reference