A cluster of aromatic amino acids in the i2 loop plays a key role for Gs coupling in prostaglandin EP2 and EP3 receptors. (Q34286839)

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17 November 2019

title

A cluster of aromatic amino acids in the i2 loop plays a key role for Gs coupling in prostaglandin EP2 and EP3 receptors (English)

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17 November 2019

7

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17 November 2019

author name string

Yukihiko Sugimoto

1

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17 November 2019

Toshiyuki Nakato

2

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17 November 2019

Ayumi Kita

3

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17 November 2019

Yuko Takahashi

4

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17 November 2019

Noriyuki Hatae

5

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17 November 2019

Hiroyuki Tabata

6

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17 November 2019

Atsushi Ichikawa

8

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17 November 2019

language of work or name

English

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publication date

29 December 2003

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Journal of Biological Chemistry

17 November 2019

published in

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17 November 2019

volume

279

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17 November 2019

issue

12

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17 November 2019

page(s)

11016-11026

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G proteins: transducers of receptor-generated signals

17 November 2019

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Selective coupling of prostaglandin E receptor EP3D to multiple G proteins depending on interaction of the carboxylic acid of agonist and arginine residue of seventh transmembrane domain

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Functional interaction of the carboxylic acid group of agonists and the arginine residue of the seventh transmembrane domain of prostaglandin E receptor EP3 subtype

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Third isoform of the prostaglandin-E-receptor EP3 subtype with different C-terminal tail coupling to both stimulation and inhibition of adenylate cyclase

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The mouse prostaglandin E receptor EP2 subtype: cloning, expression, and northern blot analysis

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Augmentation of receptor-mediated adenylyl cyclase activity by Gi-coupled prostaglandin receptor subtype EP3 in a Gbetagamma subunit-independent manner

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Effects of second intracellular loop mutations on signal transduction and internalization of the gonadotropin-releasing hormone receptor

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Two distinct pathways for histamine H2 receptor down-regulation. H2 Leu124 --> Ala receptor mutant provides evidence for a cAMP-independent action of H2 agonists

21 January 2018

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Single amino acid substitutions and deletions that alter the G protein coupling properties of the V2 vasopressin receptor identified in yeast by receptor random mutagenesis

21 January 2018

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Identification of a receptor/G-protein contact site critical for signaling specificity and G-protein activation

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Molecular basis of receptor/G protein coupling selectivity studied by coexpression of wild type and mutant m2 muscarinic receptors with mutant G alpha(q) subunits

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Different single receptor domains determine the distinct G protein coupling profiles of members of the vasopressin receptor family

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Specificity and functional applications of antipeptide antisera which identify G-protein alpha subunits

21 January 2018

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Hydrophobicity of residue351 of the G protein Gi1 alpha determines the extent of activation by the alpha 2A-adrenoceptor.

21 January 2018

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Effective information transfer from the alpha 1b-adrenoceptor to Galpha 11 requires both beta/gamma interactions and an aromatic group four amino acids from the C terminus of the G protein

21 January 2018

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Crystal structure of rhodopsin: A G protein-coupled receptor

21 January 2018

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Amino acid residues conferring ligand binding properties of prostaglandin I and prostaglandin D receptors. Identification by site-directed mutagenesis

21 January 2018

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Selective coupling of prostaglandin E receptor EP3D to Gi and Gs through interaction of alpha-carboxylic acid of agonist and arginine residue of seventh transmembrane domain

21 January 2018

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Characterization of functional interaction of carboxylic acid group of agonists and arginine of the seventh transmembrane domains of four prostaglandin E receptor subtypes

21 January 2018

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The key amino acid residue of prostaglandin EP3 receptor for governing G protein association and activation steps

21 January 2018

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Two isoforms of the prostaglandin E receptor EP3 subtype different in agonist-independent constitutive activity

21 January 2018

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Prostaglandin E receptor EP3gamma isoform, with mostly full constitutive Gi activity and agonist-dependent Gs activity

21 January 2018

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Functional role of carboxyl-terminal tail of prostaglandin EP3 receptor in Gi coupling

21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M307404200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14699136%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

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