Human antibodies from transgenic mice (Q34289925)

1 August 2017

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title

Human antibodies from transgenic mice (English)

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1 August 2017

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Lonberg N

1

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PubMed ID

7494109

1 August 2017

Huszar D

series ordinal

2

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PubMed ID

7494109

1 August 2017

language of work or name

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1 January 1995

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International Reviews of Immunology

1 August 2017

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1 August 2017

13

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1 August 2017

65-93

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1 August 2017

1

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A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene

1 August 2017

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

RAG-1-deficient mice have no mature B and T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Analysis of homozygous mutant chimeric mice: deletion of the immunoglobulin heavy-chain joining region blocks B-cell development and antibody production

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Rearrangement of a chicken immunoglobulin gene occurs in the lymphoid lineage of transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Rearrangement and expression of rabbit immunoglobulin kappa light chain gene in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Immunoglobulin kappa light chain gene promoter and enhancer are not responsible for B-cell restricted gene rearrangement

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

A repertoire of monoclonal antibodies with human heavy chains from transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

A transgenic mouse that expresses a diversity of human sequence heavy and light chain immunoglobulins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Transgenic mice containing a human heavy chain immunoglobulin gene fragment cloned in a yeast artificial chromosome

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Creation of mice expressing human antibody light chains by introduction of a yeast artificial chromosome containing the core region of the human immunoglobulin kappa locus.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Human immunoglobulin transgenes undergo rearrangement, somatic mutation and class switching in mice that lack endogenous IgM.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Antigen-specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Antibodies generated from human immunoglobulin miniloci in transgenic mice

21 January 2018

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https://api.crossref.org/works/10.3109%2F08830189509061738

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Structure and physical map of 64 variable segments in the 3'0.8-megabase region of the human immunoglobulin heavy-chain locus

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

The human immunoglobulin kappa locus consists of two copies that are organized in opposite polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Complete physical map of the human immunoglobulin heavy chain constant region gene complex

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Germ-line transformation of mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy-chain locus.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Complex pattern of immunoglobulin mu gene expression in normal and transgenic mice: nonoverlapping regulatory sequences govern distinct tissue specificities

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

A second B cell-specific enhancer 3' of the immunoglobulin heavy-chain locus

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

The mouse IgH 3'-enhancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

An enhancer at the 3' end of the mouse immunoglobulin heavy chain locus

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Cytokines and Ig switching: evolutionary divergence between mice and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

The immunoglobulin heavy chain locus contains another B-cell-specific 3' enhancer close to the alpha constant region

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

A second promoter and enhancer element within the immunoglobulin heavy chain locus.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

C mu-containing transcripts initiate heterogeneously within the IgH enhancer region and contain a novel 5'-nontranslatable exon

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Coordination of immunoglobulin DJH transcription and D-to-JH rearrangement by promoter-enhancer approximation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Synthesis of germ-line gamma 1 immunoglobulin heavy-chain transcripts in resting B cells: induction by interleukin 4 and inhibition by interferon gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Structure and expression of murine germ-line immunoglobulin epsilon heavy chain transcripts induced by interleukin 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Germline transcripts of the murine immunoglobulin gamma 2a gene: structure and induction by IFN-gamma.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Replacement of germ-line epsilon promoter by gene targeting alters control of immunoglobulin heavy chain class switching

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Structure and expression of germline epsilon transcripts in human B cells induced by interleukin 4 to switch to IgE production

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

High-level expression of a human immunoglobulin gamma 1 transgene depends on switch region sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

A new human immunoglobulin VH family preferentially rearranged in immature B-cell tumours.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Early restriction of the human antibody repertoire.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Expressed human immunoglobulin kappa genes and their hypermutation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Development of human anti-murine antibody (HAMA) response in patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Current applications of monoclonal antibodies for the therapy of hematopoietic cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Specificity analysis of human monoclonal antibodies reactive with cell surface and intracellular antigens

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Detection of cell surface and intracellular antigens by human monoclonal antibodies. Hybrid cell lines derived from lymphocytes of patients with malignant melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Isotype switching by a microinjected mu immunoglobulin heavy chain gene in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Isotype switching of an immunoglobulin heavy chain transgene occurs by DNA recombination between different chromosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Shutdown of class switch recombination by deletion of a switch region control element.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Production of sterile transcripts of C gamma genes in an IgM-producing human neoplastic B cell line that switches to IgG-producing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Sequences of human immunoglobulin switch regions: implications for recombination and transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Extensive and selective mutation of a rearranged VH5 gene in human B cell chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Lack of extensive mutations in the VH5 genes used in common B cell chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Molecular evolution of the human immunoglobulin E response: high incidence of shared mutations and clonal relatedness among epsilon VH5 transcripts from three unrelated patients with atopic dermatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Structure of Germline Immunoglobulin Heavy-Chainγ1 Transcripts in Interleukin 4 Treated Mouse Spleen Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

The IL-4 induced increase in the frequency of resting murine splenic B cells expressing germline Ig heavy chain gamma 1 transcripts correlates with subsequent switching to IgG1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Interleukin 10 and transforming growth factor beta cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Human antibody production in transgenic mice: expression from 100 kb of the human IgH locus

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

Antigen-specific human antibodies from mice comprising four distinct genetic modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189509061738

10.3109/08830189509061738

21 January 2018

Identifiers

DOI

1 reference

1 August 2017

1 reference

PubMed ID

7494109