The sialyl-alpha2,6-lactosaminyl-structure: biosynthesis and functional role (Q34292917)

1 August 2017

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title

The sialyl-alpha2,6-lactosaminyl-structure: biosynthesis and functional role (English)

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1 August 2017

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ChEBI release 2020-05-28

Dall'Olio F

1

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1 August 2017

language of work or name

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1 October 2000

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1 August 2017

published in

Glycoconjugate Journal

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1 August 2017

volume

17

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1 August 2017

issue

10

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1 August 2017

page(s)

669-676

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Enzymatic properties of beta-D-galactoside alpha2 leads to 6 sialytransferase from bovine colostrum

1 August 2017

cites work

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12 December 2020

Characterization of a promoter region supporting transcription of a novel human beta-galactoside alpha-2,6-sialyltransferase transcript in HepG2 cells

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12 December 2020

Alteration in sialyltransferase and sialic acid expression accompanies cell differentiation in rat intestine.

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12 December 2020

Different sialyltransferase activities in human colorectal carcinoma cells from surgical specimens detected by specific glycoprotein and glycolipid acceptors

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12 December 2020

Enzymic control of the expression of the X determinant (CD15) in human myeloid cells during maturation: the regulatory role of 6-sialytransferase

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12 December 2020

Carbohydrate composition of serum transferrin in alcoholic patients

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12 December 2020

The B cell antigen CD75 is a cell surface sialytransferase

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12 December 2020

Selective loss of sialic acid from rat small intestinal epithelial cells during postnatal development: demonstration with lectin-gold techniques

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12 December 2020

Hyperresponsive B cells in CD22-deficient mice

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12 December 2020

Murine hepatic beta-galactoside alpha 2,6-sialyltransferase gene expression involves usage of a novel upstream exon region.

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12 December 2020

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12 December 2020

Hepatic acute phase induction of murine beta-galactoside alpha 2,6 sialyltransferase (ST6Gal I) is IL-6 dependent and mediated by elevation of exon H-containing class of transcripts

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12 December 2020

The signal anchor and stem regions of the beta-galactoside alpha 2,6-sialyltransferase may each act to localize the enzyme to the Golgi apparatus

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12 December 2020

Sialylation of intestinal microvillar membranes in newborn, sucking and weaned pigs

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12 December 2020

Purification of alpha 2,6-sialyltransferase from rat liver by dye chromatography

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12 December 2020

A disulfide-bonded dimer of the Golgi beta-galactoside alpha2,6-sialyltransferase is catalytically inactive yet still retains the ability to bind galactose

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12 December 2020

Tissue-specific expression of beta-galactoside alpha-2,6-sialyltransferase. Transcript heterogeneity predicts a divergent polypeptide

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12 December 2020

Regulated expression of alpha 2,6-sialyltransferase by the liver-enriched transcription factors HNF-1, DBP, and LAP

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12 December 2020

Increased CMP-NeuAc:Gal beta 1,4GlcNAc-R alpha 2,6 sialyltransferase activity in human colorectal cancer tissues

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12 December 2020

Transcriptional regulation of the liver beta-galactoside alpha 2,6-sialyltransferase by glucocorticoids

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12 December 2020

Human colon cancer cell lines permanently expressing alpha 2,6-sialylated sugar chains by transfection with rat beta-galactoside alpha 2,6 sialyltransferase cDNA.

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12 December 2020

Expression of alpha 2,6-sialylated sugar chains in normal and neoplastic colon tissues. Detection by digoxigenin-conjugated Sambucus nigra agglutinin

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12 December 2020

A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP

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12 December 2020

Expression of Sia alpha 2-->6Gal beta 1-->4GlcNAc residues on sugar chains of glycoproteins including carcinoembryonic antigens in human colon adenocarcinoma: applications of Trichosanthes japonica agglutinin I for early diagnosis

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12 December 2020

Sialyltransferase isoforms are phosphorylated in the cis-medial Golgi on serine and threonine residues in their luminal sequences

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12 December 2020

The role of a cathepsin D-like activity in the release of Gal beta 1-4GlcNAc alpha 2-6-sialyltransferase from rat liver Golgi membranes during the acute-phase response

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12 December 2020

The expression of soluble and cell-bound alpha 2,6 sialyltransferase in human colonic carcinoma CaCo-2 cells correlates with the degree of enterocytic differentiation

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12 December 2020

Analysis of kidney mRNAs expressed from the rat beta-galactoside alpha 2,6-sialyltransferase gene

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12 December 2020

Sialylation of the B lymphocyte molecule CD22 by alpha 2,6-sialyltransferase is implicated in the regulation of CD22-mediated adhesion

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12 December 2020

Purification and characterization of ?(2-6)-sialyltransferase from human liver

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12 December 2020

Enhanced CMP-NeuAc:Galβ1, 4GlcNAc-R α2, 6 sialyltransferase activity of human colon cancer xenografts in athymic nude mice and of xenograft-derived cell lines

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12 December 2020

Regulation of expression of β-galactoside α2, 6-sialyltransferase in a rat tumor, Zajdela ascitic hepatoma

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12 December 2020

The B lymphocyte adhesion molecule CD22 interacts with leukocyte common antigen CD45RO on T cells and alpha 2-6 sialyltransferase, CD75, on B cells

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12 December 2020

Differential expression of five sialyltransferase genes in human tissues.

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12 December 2020

CDw75 antigen expression in human gastric carcinoma and adjacent mucosa.

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12 December 2020

Alpha 2,6-sialyltransferase predominates in cultured jejunum of suckling rats: it is up-regulated by dexamethasone and secreted during cultivation

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12 December 2020

The gene encoding beta-galactoside alpha2,6-sialyltransferase maps to mouse chromosome 16

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12 December 2020

Characterization of terminal sialic acid linkages on human thymocytes. Correlation between lectin-binding phenotype and sialyltransferase expression

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12 December 2020

Siglecs: a family of sialic-acid binding lectins

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12 December 2020

Differentiation -dependent expression of human beta-galactoside alpha 2,6-sialyltransferase mRNA in colon carcinoma CaCo-2 cells

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12 December 2020

Colon carcinoma glycoproteins carrying alpha 2,6-linked sialic acid reactive with Sambucus nigra agglutinin are not constitutively expressed in normal human colon mucosa and are distinct from sialyl-Tn antigen

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12 December 2020

Differentiation elicits negative regulation of human beta-galactoside alpha2,6-sialyltransferase at the mRNA level in the HL-60 cell line

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12 December 2020

n-butyrate reduces the expression of beta-galactoside alpha 2,6-sialyltransferase in Hep G2 cells

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12 December 2020

Transcriptional regulation. A closer look at E2F.

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12 December 2020

CD22, a B cell-specific immunoglobulin superfamily member, is a sialic acid-binding lectin

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12 December 2020

Masking and unmasking of the sialic acid-binding lectin activity of CD22 (Siglec-2) on B lymphocytes

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12 December 2020

A single N-linked glycosylation site is implicated in the regulation of ligand recognition by the I-type lectins CD22 and CD33.

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12 December 2020

Chromosome mapping and organization of the human beta-galactoside alpha 2,6-sialyltransferase gene. Differential and cell-type specific usage of upstream exon sequences in B-lymphoblastoid cells

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12 December 2020

Regulation of hepatocytic glycoprotein sialylation and sialyltransferases by peroxisome proliferators

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12 December 2020

Differential expression of cell surface sialoglycoconjugates on wild-type and cultured Ehrlich tumor cells as revealed by quantitative lectin-gold ultrastructural cytochemistry

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12 December 2020

The c-Ha-ras oncogene induces increased expression of beta-galactoside alpha-2, 6-sialyltransferase in rat fibroblast (FR3T3) cells.

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12 December 2020

Cell surface sialoprotein alterations in metastatic murine colon cancer cell lines selected in an animal model for colon cancer metastasis

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12 December 2020

Tissue-specific expression of sialyltransferases

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12 December 2020

Multiplex reverse transcription polymerase chain reaction assessment of sialyltransferase expression in human breast cancer

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12 December 2020

Thyrotropin regulation of sialic acid expression in rat thyroid cells.

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12 December 2020

Differences in cell surface carbohydrates, and in laminin and fibronectin synthesis, between adherent and non-adherent Ehrlich ascites tumor cells

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12 December 2020

Transcription of the beta-galactoside alpha 2,6-sialyltransferase gene in B lymphocytes is directed by a separate and distinct promoter

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12 December 2020

Expression of Gal beta 1,4GlcNAc alpha 2,6-sialyltransferase and alpha 2,6-linked sialoglycoconjugates in normal human and rat tissues

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12 December 2020

The HB-6, CDw75, and CD76 differentiation antigens are unique cell-surface carbohydrate determinants generated by the beta-galactoside alpha 2,6-sialyltransferase

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12 December 2020

Characterization of sialyloligosaccharide binding by recombinant soluble and native cell-associated CD22. Evidence for a minimal structural recognition motif and the potential importance of multisite binding

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12 December 2020

Specific sequences in the signal anchor of the beta-galactoside alpha-2,6-sialyltransferase are not essential for Golgi localization. Membrane flanking sequences may specify Golgi retention

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12 December 2020

Regulation of beta-galactoside alpha 2,6-sialyltransferase gene expression by dexamethasone

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12 December 2020

Transcriptional induction of beta-galactoside alpha-2,6-sialyltransferase in rat fibroblast by dexamethasone

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12 December 2020

Altered mRNA expression of glycosyltransferases in human colorectal carcinomas and liver metastases

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12 December 2020

Quantitative lectin-histochemical and immunohistochemical studies on the occurrence of alpha(2,3)- and alpha(2,6)-linked sialic acid residues in colorectal carcinomas. Relation to clinicopathologic features.

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12 December 2020

Differential expression of alpha2-6 sialylated polylactosamine structures by human B and T cells

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12 December 2020

Enzymatic amplification involving glycosyltransferases forms the basis for the increased size of asparagine-linked glycans at the surface of NIH 3T3 cells expressing the N-ras proto-oncogene.

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12 December 2020

Enhanced activity of CMP-neuAc:Gal beta 1-4GlcNAc:alpha 2,6-sialyltransferase in metastasizing human colorectal tumor tissue and serum of tumor patients

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12 December 2020

Two step single primer mediated polymerase chain reaction. Application to cloning of putative mouse, beta-galactoside alpha 2,6-sialyltransferase cDNA.

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12 December 2020

Ecto-sialyltransferase of human B lymphocytes reconstitutes differentiation markers in the presence of exogenous CMP-N-acetyl neuraminic acid.

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12 December 2020

Chronic ethanol consumption leads to destabilization of rat liver beta-galactoside alpha2,6-sialyltransferase mRNA

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12 December 2020

Glucocorticoid induction of the alpha2,6 sialyltransferase enzyme in a mouse neural cell line

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12 December 2020

High alpha-2,6-sialylation of N-acetyllactosamine sequences in ras-transformed rat fibroblasts correlates with high invasive potential

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12 December 2020

Regulation of CD45 engagement by the B-cell receptor CD22.

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12 December 2020

Cytokine-induced beta-galactoside alpha-2,6-sialyltransferase in human endothelial cells mediates alpha 2,6-sialylation of adhesion molecules and CD22 ligands.

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12 December 2020

Monoclonal antibodies raised against NeuAc alpha 2-6neolactotetraosylceramide detect carcinoma-associated gangliosides.

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12 December 2020

Beta-galactoside alpha2,6 sialyltransferase in human colon cancer: contribution of multiple transcripts to regulation of enzyme activity and reactivity with Sambucus nigra agglutinin

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12 December 2020

Sialyltransferase messenger ribonucleic acid increases in thyrotrophs of hypothyroid mice: an in situ hybridization study

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12 December 2020

Molecular cloning, expression and exon/intron organization of the bovine beta-galactoside alpha2,6-sialyltransferase gene

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12 December 2020

Effect of ethanol on human colon carcinoma CaCo-2 and HT-29 cell lines during the maturation process

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12 December 2020

The expression of Gal beta 1,4GlcNAc alpha 2,6 sialyltransferase and alpha 2,6-linked sialoglycoconjugates in human brain tumors

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12 December 2020

Sialylation and malignant potential in tumour cell glycosylation mutants

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12 December 2020

HB4 antibody recognizes a carbohydrate structure on lymphocyte surface proteins related to HB6, CDw75, and CD76 antigens.

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12 December 2020

Serum carbohydrate-deficient transferrin: Mechanism of increase after chronic alcohol intake

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12 December 2020

Novel heterogeneity exists in the 5'-untranslated region of the beta-galactoside alpha 2,6-sialytransferase mRNAs in the human B-lymphoblastoid cell line, louckes

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12 December 2020

Microbial recognition of target-cell glycoconjugates

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12 December 2020

Purification of a sialyltransferase from bovine colostrum by affinity chromatography on CDP-agarose

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12 December 2020

Up-regulation of alpha2,6 sialylation during myeloid maturation: a potential role in myeloid cell release from the bone marrow

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12 December 2020

Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

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12 December 2020

Release of sialyltransferases from rat liver Golgi membranes by a cathepsin D-like proteinase: comparison of the release of Gal beta 1-4GlcNAc alpha 2-6 sialyltransferase, Gal beta 1-3(4)GlcNAc alpha 2-3 sialyltransferase and lactosylceramide alpha

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12 December 2020

Purification of a Gal beta 1 to 4GlcNAc alpha 2 to 6 sialyltransferase and a Gal beta 1 to 3(4)GlcNAc alpha 2 to 3 sialyltransferase to homogeneity from rat liver.

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12 December 2020

Interferon alpha-2b modulates beta-galactoside alpha-2,6-sialyltransferase gene expression in rat testes

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12 December 2020

CD22-mediated cell adhesion to cytokine-activated human endothelial cells. Positive and negative regulation by alpha 2-6-sialylation of cellular glycoproteins

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12 December 2020

The 17-residue transmembrane domain of beta-galactoside alpha 2,6-sialyltransferase is sufficient for Golgi retention

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12 December 2020

Immune regulation by the ST6Gal sialyltransferase

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12 December 2020

Transcription of the beta-galactoside alpha2,6-sialyltransferase gene (SIAT1) in B-lymphocytes: cell type-specific expression correlates with presence of the divergent 5'-untranslated sequence

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12 December 2020

Conversion of a Golgi apparatus sialyltransferase to a secretory protein by replacement of the NH2-terminal signal anchor with a signal peptide

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12 December 2020

Postnatal development of rat colon epithelial cells is associated with changes in the expression of the beta 1,4-N-acetylgalactosaminyltransferase involved in the synthesis of Sda antigen of alpha 2,6-sialyltransferase activity towards N-acetyl-lact

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12 December 2020

Elevation of alpha2-->6 sialyltransferase and alpha1-->2 fucosyltransferase activities in human choriocarcinoma

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12 December 2020

The elderberry (Sambucus nigra L.) bark lectin recognizes the Neu5Ac(alpha 2-6)Gal/GalNAc sequence.

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12 December 2020

Murine B cell differentiation is accompanied by programmed expression of multiple novel beta-galactoside alpha2, 6-sialyltransferase mRNA forms

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12 December 2020

Regulation of lymphocyte activation by the cell-surface molecule CD22

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12 December 2020

Expression and regulation of glycosyltransferases for N-glycosyl oligosaccharides in fresh human surgical and murine tissues and cultured cell lines

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12 December 2020

Differential expression of the hepatic transcript of beta-galactoside alpha2,6-sialyltransferase in human colon cancer cell lines

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12 December 2020

Human Golgi beta-galactoside alpha-2,6-sialyltransferase generates a group of sialylated B lymphocyte differentiation antigens

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12 December 2020

Altered mRNA expression of glycosyltransferases in human gastric carcinomas

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12 December 2020

The role of the carbohydrate chains of Gal beta-1,4-GlcNAc alpha 2,6-sialyltransferase for enzyme activity

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12 December 2020

Organization of the beta-galactoside alpha 2,6-sialyltransferase gene. Evidence for the transcriptional regulation of terminal glycosylation.

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12 December 2020

Cell-specific expression of human beta-galactoside alpha 2,6-sialyltransferase transcripts differing in the 5' untranslated region

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12 December 2020

Up-regulation of a set of glycosyltransferase genes in human colorectal cancer.

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12 December 2020

Sequences within and adjacent to the transmembrane segment of alpha-2,6-sialyltransferase specify Golgi retention

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12 December 2020

Coordinate expression of beta-galactoside alpha 2,6-sialyltransferase mRNA and enzyme activity in suckling rat jejunum cultured in different media: transcriptional induction by dexamethasone

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12 December 2020

Transcriptional regulation of human beta-galactoside alpha2, 6-sialyltransferase (hST6Gal I) gene during differentiation of the HL-60 cell line

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12 December 2020

Expression of beta-galactoside alpha 2,6-sialyltransferase does not alter the susceptibility of human colon cancer cells to NK-mediated cell lysis

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12 December 2020

Cell surface sialylation and tumor metastasis. Metastatic potential of B16 melanoma variants correlates with their relative numbers of specific penultimate oligosaccharide structures

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12 December 2020

Differential expression of alpha2,6-sialyltransferase in colon tumors recognized by a monoclonal antibody

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12 December 2020

The oligosaccharide binding specificities of CD22 beta, a sialic acid-specific lectin of B cells

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12 December 2020

The B lymphocyte surface antigen CD75 is not an alpha-2,6-sialyltransferase but is a carbohydrate antigen, the production of which requires the enzyme

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12 December 2020

Developmental regulation of beta-galactoside alpha 2,6-sialyltransferase in small intestine epithelium.

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12 December 2020

Effect of acute and chronic ethanol administration on rat liver alpha 2,6-sialyltransferase activity responsible for sialylation of serum transferrin

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12 December 2020

Increased alpha2,6 sialylation of N-glycans in a transgenic mouse model of hepatocellular carcinoma

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12 December 2020

alpha2,6-Sialyltransferase gene transfection into a human glioma cell line (U373 MG) results in decreased invasivity

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12 December 2020

Comparative study of the levels of sialyltransferases responsible for the formation of sugar chains in glycoproteins and gangliosides in rat liver and hepatomas.

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12 December 2020

Natural ligands of the B cell adhesion molecule CD22 beta carry N-linked oligosaccharides with alpha-2,6-linked sialic acids that are required for recognition.

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12 December 2020

Rat beta-galactoside alpha 2,6-sialyltransferase genomic organization: alternate promoters direct the synthesis of liver and kidney transcripts

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12 December 2020

Molecular cloning and expression of chick embryo Gal beta 1,4GlcNAc alpha 2,6-sialyltransferase. Comparison with the mammalian enzyme

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12 December 2020

Accumulation of gangliosides with N-acetylneuraminosyl(alpha 2-6)lactosamine structure in primary human hepatoma

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12 December 2020

A monoclonal antibody directed to N-acetylneuraminosyl-alpha 2 leads to 6-galactosyl residue in gangliosides and glycoproteins

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12 December 2020

Expression of the CDw75 (beta-galactoside alpha 2,6-sialyltransferase) antigen on normal blood cells and in B-cell chronic lymphocytic leukaemia

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12 December 2020

Isolation and characterization of a partial cDNA for a human sialyltransferase

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12 December 2020

Expression of alpha 2,6-linked sialic acid residues in neoplastic but not in normal human colonic mucosa. A lectin-gold cytochemical study with Sambucus nigra and Maackia amurensis lectins

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12 December 2020

Complete cDNA sequence encoding human beta-galactoside alpha-2,6-sialyltransferase

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12 December 2020

Engagement of the adhesion receptor CD22 triggers a potent stimulatory signal for B cells and blocking CD22/CD22L interactions impairs T-cell proliferation

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12 December 2020

Tissue-specific alternative splicing of the beta-galactoside alpha 2,6-sialyltransferase gene.

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12 December 2020

Alpha 2,6 sialylation of N-acetyllactosaminic sequences in human colorectal cancer cell lines. Relationship with non-adherent growth

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12 December 2020

Two naturally occurring alpha2,6-sialyltransferase forms with a single amino acid change in the catalytic domain differ in their catalytic activity and proteolytic processing

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12 December 2020

Primary structure of beta-galactoside alpha 2,6-sialyltransferase. Conversion of membrane-bound enzyme to soluble forms by cleavage of the NH2-terminal signal anchor

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12 December 2020

Evolutionary considerations in relating oligosaccharide diversity to biological function

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12 December 2020

The acute phase response

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12 December 2020

Studies on the effect of inflammation on rat liver and serum sialyltransferase. Evidence that inflammation causes release of Gal beta 1 leads to 4GlcNAc alpha 2 leads to 6 sialyltransferase from liver

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12 December 2020

Identifiers

DOI

10.1023/A:1011077000164

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Dimensions Publication ID

1 August 2017

1036430107

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