The rapamycin-sensitive signal transduction pathway as a target for cancer therapy (Q34293622)

1 August 2017

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title

The rapamycin-sensitive signal transduction pathway as a target for cancer therapy (English)

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1 August 2017

Hidalgo M

1

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1 August 2017

Rowinsky EK

series ordinal

2

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1 August 2017

language of work or name

English

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publication date

1 December 2000

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1 August 2017

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1 August 2017

19

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1 August 2017

56

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1 August 2017

6680-6686

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1204091

1 August 2017

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cites work

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Anticancer agents targeting signaling molecules and cancer cell environment: challenges for drug development?

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4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

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Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability

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Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin

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Activation of p70 S6 kinase and erk-encoded mitogen-activated protein kinases is resistant to high cyclic nucleotide levels in Swiss 3T3 fibroblasts

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PIK3CA is implicated as an oncogene in ovarian cancer.

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The mRNA 5' cap-binding protein eIF4E and control of cell growth

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Inhibition of MG-63 cell proliferation and PDGF-stimulated cellular processes by inhibitors of phosphatidylinositol 3-kinase

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The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

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Rapamycin, a potent immunosuppressive drug, causes programmed cell death in B lymphoma cells

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Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

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Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.

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Rapamune (Sirolimus, rapamycin): an overview and mechanism of action.

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Mechanism of action of rapamycin: new insights into the regulation of G1-phase progression in eukaryotic cells

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7 January 2021

The monitoring of immunosuppressive drugs: a pharmacodynamic approach

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1204091

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Dimensions Publication ID

1 August 2017

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