Synergism between basic Asp49 and Lys49 phospholipase A2 myotoxins of viperid snake venom in vitro and in vivo (Q34301758)

1 August 2017

title

Synergism between basic Asp49 and Lys49 phospholipase A2 myotoxins of viperid snake venom in vitro and in vivo (English)

1 reference

1 August 2017

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Bruno Lomonte

5

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José María Gutiérrez

object named as

José María Gutiérrez

series ordinal

4

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Cesare Montecucco

series ordinal

3

object named as

Cesare Montecucco

1 reference

1 August 2017

1

Diana Mora-Obando

1 reference

1 August 2017

Julián Fernández

2

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1 August 2017

language of work or name

English

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publication date

7 October 2014

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1 August 2017

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1 August 2017

volume

9

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1 August 2017

issue

10

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1 August 2017

page(s)

e109846

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Creative Commons Attribution 4.0 International

1 August 2017

copyright license

start time

7 October 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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6 July 2018

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Muscle phospholipid hydrolysis by Bothrops asper Asp49 and Lys49 phospholipase A₂ myotoxins--distinct mechanisms of action

6 July 2018

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The venom optimization hypothesis revisited.

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Phospholipases A2: unveiling the secrets of a functionally versatile group of snake venom toxins

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6 July 2018

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Synergism between baltergin metalloproteinase and Ba SPII RP4 PLA2 from Bothrops alternatus venom on skeletal muscle (C2C12) cells.

6 July 2018

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Structural, functional, and bioinformatics studies reveal a new snake venom homologue phospholipase A₂ class

6 July 2018

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Bothrops snake myotoxins induce a large efflux of ATP and potassium with spreading of cell damage and pain

6 July 2018

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Comparison between apo and complexed structures of bothropstoxin-I reveals the role of Lys122 and Ca(2+)-binding loop region for the catalytically inactive Lys49-PLA(2)s

6 July 2018

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6 July 2018

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The C-terminal region of a Lys49 myotoxin mediates Ca2+ influx in C2C12 myotubes

6 July 2018

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The intriguing phospholipases A2 homologues: relevant structural features on myotoxicity and catalytic inactivity

6 July 2018

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The phospholipase A2 homologues of snake venoms: biological activities and their possible adaptive roles

6 July 2018

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Calcium imaging of muscle cells treated with snake myotoxins reveals toxin synergism and presence of acceptors.

6 July 2018

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6 July 2018

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Cellular pathology induced by snake venom phospholipase A2 myotoxins and neurotoxins: common aspects of their mechanisms of action.

6 July 2018

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Inventing an arsenal: adaptive evolution and neofunctionalization of snake venom phospholipase A2 genes

6 July 2018

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Differential susceptibility of C2C12 myoblasts and myotubes to group II phospholipase A2 myotoxins from crotalid snake venoms.

6 July 2018

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Skeletal muscle degeneration induced by venom phospholipases A2: insights into the mechanisms of local and systemic myotoxicity

6 July 2018

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An overview of lysine-49 phospholipase A2 myotoxins from crotalid snake venoms and their structural determinants of myotoxic action

6 July 2018

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Mapping structural determinants of biological activities in snake venom phospholipases A2 by sequence analysis and site directed mutagenesis.

6 July 2018

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Chemical modifications of phospholipases A2 from snake venoms: effects on catalytic and pharmacological properties

6 July 2018

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Excitement ahead: structure, function and mechanism of snake venom phospholipase A2 enzymes

6 July 2018

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Assembling an arsenal: origin and evolution of the snake venom proteome inferred from phylogenetic analysis of toxin sequences

6 July 2018

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Active-site mutagenesis of a Lys49-phospholipase A2: biological and membrane-disrupting activities in the absence of catalysis

6 July 2018

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Identification of the myotoxic site of the Lys49 phospholipase A(2) from Agkistrodon piscivorus piscivorus snake venom: synthetic C-terminal peptides from Lys49, but not from Asp49 myotoxins, exert membrane-damaging activities

6 July 2018

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Comparative study of the cytolytic activity of myotoxic phospholipases A2 on mouse endothelial (tEnd) and skeletal muscle (C2C12) cells in vitro

6 July 2018

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Phospholipase A2--a structural review

6 July 2018

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Phospholipase A2 myotoxins from Bothrops snake venoms

6 July 2018

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Neutralizing interaction between heparins and myotoxin II, a lysine 49 phospholipase A2 from Bothrops asper snake venom. Identification of a heparin-binding and cytolytic toxin region by the use of synthetic peptides and molecular modeling.

6 July 2018

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Accelerated evolution in the protein-coding regions is universal in crotalinae snake venom gland phospholipase A2 isozyme genes

6 July 2018

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6 July 2018

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A new muscle damaging toxin, myotoxin II, from the venom of the snake Bothrops asper (terciopelo).

6 July 2018

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Muscle necrosis caused by snake venoms and toxins

6 July 2018

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Myotoxin II from Bothrops asper (Terciopelo) venom is a lysine-49 phospholipase A2.

6 July 2018

1 reference

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Crystallographic and biochemical studies of the (inactive) Lys-49 phospholipase A2 from the venom of Agkistridon piscivorus piscivorus

6 July 2018

1 reference

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Myotoxicity and physiological effects of three Trimeresurus flavoviridis phospholipases A2

6 July 2018

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Restoration of enzymatic activity in a Ser-49 phospholipase A2 homologue decreases its Ca(2+)-independent membrane-damaging activity and increases its toxicity

6 July 2018

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Chemical modification of histidine and lysine residues of myotoxic phospholipases A2 isolated from Bothrops asper and Bothrops godmani snake venoms: effects on enzymatic and pharmacological properties.

21 January 2018

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Comparative study of synthetic peptides corresponding to region 115-129 in Lys49 myotoxic phospholipases A2 from snake venoms

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0109846

Distinct sites for myotoxic and membrane-damaging activities in the C-terminal region of a Lys49-phospholipase A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0109846

Purification, sequencing, and phylogenetic analyses of novel Lys-49 phospholipases A(2) from the venoms of rattlesnakes and other pit vipers

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0109846

Structural characterization and phylogenetic relationships of myotoxin II from Atropoides (Bothrops) nummifer snake venom, a Lys49 phospholipase A(2) homologue

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0109846

Isolation of a myotoxin from Bothrops asper venom: partial characterization and action on skeletal muscle.

21 January 2018

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Why myotoxin-containing snake venoms possess powerful nucleotidases?

21 January 2018

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Isolation of an acidic phospholipase A2 from the venom of the snake Bothrops asper of Costa Rica: Biochemical and toxicological characterization☆

28 October 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0109846

The amino acid sequence of a myotoxic phospholipase from the venom of Bothrops asper

21 January 2018

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Skeletal Muscle Necrosis and Regeneration after Injection of BaH1, A Hemorrhagic Metalloproteinase Isolated from the Venom of the Snake Bothrops asper (Terciopelo)

21 January 2018

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The effect of myotoxins isolated from Bothrops snake venoms on multilamellar liposomes: relationship to phospholipase A2, anticoagulant and myotoxic activities

21 January 2018

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Calcium ion independent membrane leakage induced by phospholipase-like myotoxins

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25290688

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

An aqueous endpoint assay of snake venom phospholipase A2

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25290688

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A new class of phospholipases A2 with lysine in place of aspartate 49. Functional consequences for calcium and substrate binding

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25290688

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0109846

1 reference

1 August 2017

0 references

1 reference

1 August 2017

1 reference