IL-4 signaling, gene transcription regulation, and the control of effector T cells (Q34303143)

1 August 2017

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title

IL-4 signaling, gene transcription regulation, and the control of effector T cells (English)

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1 August 2017

Boothby M

1

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1 August 2017

Mora AL

2

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1 August 2017

Aronica MA

3

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1 August 2017

Youn J

4

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1 August 2017

Sheller JR

5

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1 August 2017

Goenka S

6

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1 August 2017

Stephenson L

7

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1 August 2017

1 January 2001

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1 August 2017

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1 August 2017

23

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1 August 2017

2-3

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1 August 2017

179-191

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https://scigraph.springernature.com/pub.10.1385/ir:23:2-3:179

1 August 2017

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cites work

IL-4 Rapidly Produced by Vβ4 Vα8 CD4+ T Cells Instructs Th2 Development and Susceptibility to Leishmania major in BALB/c Mice

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12 December 2020

IL-4 and IL-13 production in differentiated T helper type 2 cells is not IL-4 dependent.

1 reference

12 December 2020

Multiple defects of immune cell function in mice with disrupted interferon-gamma genes

1 reference

12 December 2020

An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice.

1 reference

12 December 2020

Involvement of IL-4-producing Vbeta8.2+ CD4+ CD62L- CD45RB- T cells in non-MHC gene-controlled predisposition toward skewing into T helper type-2 immunity in BALB/c mice.

1 reference

12 December 2020

Paired Stat6 C-terminal transcription activation domains required both for inhibition of an IFN-responsive promoter and trans-activation.

1 reference

12 December 2020

CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes

1 reference

12 December 2020

Immunologic basis of antigen-induced airway hyperresponsiveness

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12 December 2020

An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth

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12 December 2020

Functional characteristics and survival requirements of memory CD4+ T lymphocytes in vivo.

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12 December 2020

Synergy between interferon-gamma and tumor necrosis factor-alpha in transcriptional activation is mediated by cooperation between signal transducer and activator of transcription 1 and nuclear factor kappaB.

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12 December 2020

T cell receptor-induced calcineurin activation regulates T helper type 2 cell development by modifying the interleukin 4 receptor signaling complex

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12 December 2020

Environmental risk factors in childhood asthma.

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12 December 2020

Lymphocyte responses and cytokines

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12 December 2020

Effects of Th2 cytokines on chemokine expression in the lung: IL-13 potently induces eotaxin expression by airway epithelial cells

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12 December 2020

Growth and gene expression are predominantly controlled by distinct regions of the human IL-4 receptor

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12 December 2020

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

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12 December 2020

In vivo function of an interleukin 2 receptor beta chain (IL-2Rbeta)/IL-4Ralpha cytokine receptor chimera potentiates allergic airway disease.

1 reference

12 December 2020

Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile

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12 December 2020

Functional differentiation of T cells in the intestine of T cell receptor transgenic mice

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12 December 2020

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function

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12 December 2020

Memory T cell development in the absence of specific antigen priming.

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12 December 2020

Phenotype of cells expressing mRNA for TH2-type (interleukin 4 and interleukin 5) and TH1-type (interleukin 2 and interferon gamma) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal control subjects.

1 reference

12 December 2020

Preferential role for NF-kappa B/Rel signaling in the type 1 but not type 2 T cell-dependent immune response in vivo

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12 December 2020

NF-kappa B/Rel participation in the lymphokine-dependent proliferation of T lymphoid cells

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12 December 2020

IL-4-dependent induction of BCL-2 and BCL-X(L)IN activated T lymphocytes through a STAT6- and pi 3-kinase-independent pathway

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12 December 2020

Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells

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12 December 2020

A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation

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12 December 2020

Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc

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12 December 2020

The non-histone chromosomal protein HMG-I(Y) contributes to repression of the immunoglobulin heavy chain germ-line epsilon RNA promoter

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12 December 2020

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming

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12 December 2020

Differential regulation of epithelial-derived C-C chemokine expression by IL-4 and the glucocorticoid budesonide.

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12 December 2020

Immunological aspects of allergic asthma

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12 December 2020

Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation

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12 December 2020

T-lymphocyte dysregulation in asthma

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12 December 2020

The interleukin-4 receptor activates STAT5 by a mechanism that relies upon common gamma-chain

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12 December 2020

Stat6 regulation of in vivo IL-4 responses

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12 December 2020

The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge

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12 December 2020

Activation of STAT6 is not dependent on phosphotyrosine-mediated docking to the interleukin-4 receptor and can be blocked by dominant-negative mutants of both receptor subunits.

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12 December 2020

The high mobility group protein HMG I(Y) is required for NF-kappa B-dependent virus induction of the human IFN-beta gene

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12 December 2020

T cells compete for access to antigen-bearing antigen-presenting cells

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12 December 2020

Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription

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12 December 2020

Peripheral selection of T cell repertoires: the role of continuous thymus output

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12 December 2020

Developing Patterns of T Cell Memory to Environmental Allergens in the First Two Years of Life

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12 December 2020

IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB.

1 reference

12 December 2020

Redirection of T cell effector function in vivo and enhanced collagen-induced arthritis mediated by an IL-2R beta/IL-4R alpha chimeric cytokine receptor transgene

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12 December 2020

Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-kappaB.

1 reference

12 December 2020

Jaks, STATs, cytokine signal transduction, and immunoregulation: are we there yet?

1 reference

12 December 2020

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells

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12 December 2020

Exposure to T helper 2 cytokines in vivo before encounter with antigen selects for T helper subsets via alterations in antigen-presenting cell function.

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12 December 2020

Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells

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12 December 2020

Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells

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12 December 2020

A novel transcription factor, T-bet, directs Th1 lineage commitment

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12 December 2020

The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines

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12 December 2020

Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment.

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12 December 2020

IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells

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12 December 2020

CD8alpha+ and CD8alpha- subclasses of dendritic cells direct the development of distinct T helper cells in vivo

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12 December 2020

Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo

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12 December 2020

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation

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12 December 2020

Functional diversity of helper T lymphocytes

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12 December 2020

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12 December 2020

Th type 1-stimulating activity of lung macrophages inhibits Th2-mediated allergic airway inflammation by an IFN-gamma-dependent mechanism

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12 December 2020

The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells

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12 December 2020

Asthma: an epidemic in the absence of infection?

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12 December 2020

Multistage regulation of Th1-type immune responses by the transcription factor IRF-1

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12 December 2020

Consequences of long-term inflammation. Airway remodeling

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12 December 2020

IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses

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12 December 2020

IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells

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12 December 2020

Inducible expression of a Th2-type CC chemokine thymus- and activation-regulated chemokine by human bronchial epithelial cells

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12 December 2020

HMG-I(Y) phosphorylation status as a nuclear target regulated through insulin receptor substrate-1 and the I4R motif of the interleukin-4 receptor

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12 December 2020

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene

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12 December 2020

The IL-4 receptor: signaling mechanisms and biologic functions

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12 December 2020

IL-12 induces IFN regulating factor-1 (IRF-1) gene expression in human NK and T cells

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12 December 2020

Interleukin-13 is a more potent inhibitor of the expression of inducible nitric oxide synthase in smooth muscle cells than in macrophages: a comparison with interleukin-4 and interleukin-10.

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12 December 2020

Lineage-specific differences among CD8+ T cells in their dependence of NF-kappa B/Rel signaling

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12 December 2020

Generation and in vivo persistence of polarized Th1 and Th2 memory cells

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12 December 2020

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

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12 December 2020

The role of the thymus and recent thymic migrants in the maintenance of the adult peripheral lymphocyte pool

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12 December 2020

Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis

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12 December 2020

Identifiers

DOI

10.1385/IR:23:2-3:179

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Dimensions Publication ID

1 August 2017

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