A centrosome-autonomous signal that involves centriole disengagement permits centrosome duplication in G2 phase after DNA damage (Q34313511)

1 August 2017

title

A centrosome-autonomous signal that involves centriole disengagement permits centrosome duplication in G2 phase after DNA damage (English)

1 reference

1 August 2017

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Burcu Inanç

1

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1 August 2017

Helen Dodson

series ordinal

2

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1 August 2017

Ciaran G Morrison

series ordinal

3

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1 August 2017

publication date

22 September 2010

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Molecular Biology of the Cell

1 August 2017

published in

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1 August 2017

volume

21

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1 August 2017

issue

22

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1 August 2017

page(s)

3866-3877

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Unscheduled expression of CDC25B in S-phase leads to replicative stress and DNA damage

1 August 2017

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6 July 2018

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DNA damage induces Chk1-dependent threonine-160 phosphorylation and activation of Cdk2.

6 July 2018

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Polo kinase and separase regulate the mitotic licensing of centriole duplication in human cells.

6 July 2018

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6 July 2018

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6 July 2018

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Centrosome amplification can initiate tumorigenesis in flies.

6 July 2018

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Oncogenes and tumour suppressors take on centrosomes

6 July 2018

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Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity

6 July 2018

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6 July 2018

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Centrosome replication in hydroxyurea-arrested CHO cells expressing GFP-tagged centrin2.

6 July 2018

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Centrosome biogenesis and function: centrosomics brings new understanding

6 July 2018

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Polo-like kinase controls vertebrate spindle elongation and cytokinesis

6 July 2018

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DNA damage induces Chk1-dependent centrosome amplification.

6 July 2018

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Centriole overduplication through the concurrent formation of multiple daughter centrioles at single maternal templates

6 July 2018

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Centrosome duplication: of rules and licenses

6 July 2018

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Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells.

6 July 2018

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Involvement of centrosome amplification in radiation-induced mitotic catastrophe

6 July 2018

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BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo.

6 July 2018

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Origins and consequences of centrosome aberrations in human cancers

6 July 2018

1 reference

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The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity

6 July 2018

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Mechanism limiting centrosome duplication to once per cell cycle

6 July 2018

1 reference

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NEDD1-dependent recruitment of the gamma-tubulin ring complex to the centrosome is necessary for centriole duplication and spindle assembly

6 July 2018

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GCP-WD is a gamma-tubulin targeting factor required for centrosomal and chromatin-mediated microtubule nucleation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Nuclear dynamics of PCNA in DNA replication and repair

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Centrosomes in cellular regulation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

The role of Polo-like kinase 1 in the inhibition of centrosome separation after ionizing radiation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Spindle multipolarity is prevented by centrosomal clustering.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Human papillomavirus type 16 E7 oncoprotein can induce abnormal centrosome duplication through a mechanism independent of inactivation of retinoblastoma protein family members

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Centrosomes split in the presence of impaired DNA integrity during mitosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Centrosome number is controlled by a centrosome-intrinsic block to reduplication

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Centrosome aberrations: cause or consequence of cancer progression?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Centrosome amplification and the development of cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Farnesylation of Cenp-F is required for G2/M progression and degradation after mitosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Disruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

"It takes two to tango": understanding how centrosome duplication is regulated throughout the cell cycle

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Expression of mutant telomerase in immortal telomerase-negative human cells results in cell cycle deregulation, nuclear and chromosomal abnormalities and rapid loss of viability

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Managing the centrosome numbers game: from chaos to stability in cancer cell division

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Induction of M-phase arrest and apoptosis after HIV-1 Vpr expression through uncoupling of nuclear and centrosomal cycle in HeLa cells.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

The respective contributions of the mother and daughter centrioles to centrosome activity and behavior in vertebrate cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Cyclin-dependent kinase control of centrosome duplication

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

p21(cip-1/waf-1) deficiency causes deformed nuclear architecture, centriole overduplication, polyploidy, and relaxed microtubule damage checkpoints in human hematopoietic cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Centrosome hypertrophy in human breast tumors: implications for genomic stability and cell polarity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Abnormal centrosome amplification in the absence of p53.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Dissociation of centrosome replication events from cycles of DNA synthesis and mitotic division in hydroxyurea-arrested Chinese hamster ovary cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Mitosis in a cell with multiple centrioles

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Centriole distribution during tripolar mitosis in Chinese hamster ovary cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Polo-like Kinase 1 Triggers the Initiation of Cytokinesis in Human Cells by Promoting Recruitment of the RhoGEF Ect2 to the Central Spindle

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Overexpression of mammalian Rad51 does not stimulate tumorigenesis while a dominant-negative Rad51 affects centrosome fragmentation, ploidy and stimulates tumorigenesis, in p53-defective CHO cells.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

DNA damage in HeLa cells induced arrest at a discrete point in G2 phase as defined by CENP-F localization

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Inhibition of Polo-like kinase-1 by DNA damage occurs in an ATM- or ATR-dependent fashion.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Polo-like kinase-1 is a target of the DNA damage checkpoint

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982117

Radiation-induced centrosome overduplication and multiple mitotic spindles in human tumor cells

28 October 2018

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12 December 2020

Mammalian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome segregation

1 reference

12 December 2020

A possible role for centrosome overduplication in radiation-induced cell death

1 reference

12 December 2020

Centrosome defects can account for cellular and genetic changes that characterize prostate cancer progression

1 reference

12 December 2020

The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1

1 reference

12 December 2020

Identifiers

DOI

10.1091/MBC.E10-02-0124

1 reference

1 August 2017

1 reference

1 August 2017

1 reference