Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants (Q34313807)

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English	Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants	scientific article

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scholarly article

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PubMed publication ID

1 August 2017

Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants (English)

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Europe PubMed Central

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1 August 2017

fibrodysplasia ossificans progressiva

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4

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1 June 2020

9

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1 June 2020

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Agustin H Mohedas

1

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1 June 2020

You Wang

2

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1 June 2020

Caroline E Sanvitale

3

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1 June 2020

Sungwoon Choi

5

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1 June 2020

Xuechao Xing

6

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1 June 2020

Alex N Bullock

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1 June 2020

Gregory D Cuny

8

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1 June 2020

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4 September 2014

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1 August 2017

Journal of Medicinal Chemistry

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1 June 2020

57

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1 June 2020

19

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1 June 2020

7900-7915

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1 June 2020

Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations

1 reference

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6 July 2018

Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma

1 reference

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1 reference

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A new class of small molecule inhibitor of BMP signaling

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6 July 2018

Constitutively active ALK2 receptor mutants require type II receptor cooperation

1 reference

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1 reference

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6 July 2018

Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva

1 reference

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A novel mutation of ALK2, L196P, found in the most benign case of fibrodysplasia ossificans progressiva activates BMP-specific intracellular signaling equivalent to a typical mutation, R206H.

1 reference

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A novel ACVR1 mutation in the glycine/serine-rich domain found in the most benign case of a fibrodysplasia ossificans progressiva variant reported to date

1 reference

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6 July 2018

TGFbeta/BMP type I receptors ALK1 and ALK2 are essential for BMP9-induced osteogenic signaling in mesenchymal stem cells

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1 reference

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Novel mutations in ACVR1 result in atypical features in two fibrodysplasia ossificans progressiva patients

1 reference

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6 July 2018

Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1

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1 reference

https://pubmed.ncbi.nlm.nih.gov/25101911

12 December 2020

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10.1021/JM501177W

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1 June 2020

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1 June 2020

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1 June 2020

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