The I1-imidazoline receptor: from binding site to therapeutic target in cardiovascular disease (Q34314025)

1 August 2017

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title

The I1-imidazoline receptor: from binding site to therapeutic target in cardiovascular disease (English)

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1 August 2017

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cardiovascular disease

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P Ernsberger

1

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PubMed ID

9050981

1 August 2017

J E Friedman

series ordinal

2

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PubMed ID

9050981

1 August 2017

R J Koletsky

series ordinal

3

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1 August 2017

1 January 1997

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Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension

1 August 2017

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1 August 2017

15

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1 August 2017

1

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1 August 2017

S9-23

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Pharmacology of moxonidine, an I1-imidazoline receptor agonist.

1 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Drug withdrawal and rebound hypertension: differential action of the central antihypertensive drugs moxonidine and clonidine

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Imidazoline receptors and their endogenous ligands

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Renal effects of infusion of rilmenidine and guanabenz in conscious dogs: contribution of peripheral and central nervous system alpha 2-adrenoceptors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Role of insulin resistance in human disease (syndrome X): an expanded definition

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Mediation of the hypotensive action of systemic clonidine in the rat by alpha 2-adrenoceptors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Phosphatidylcholine breakdown and signal transduction

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Human brain imidazoline receptors: further characterization with [3H]clonidine.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

A novel mechanism of action for hypertension control: moxonidine as a selective I1-imidazoline agonist.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Is the sympathoinhibitory effect of rilmenidine mediated by alpha-2 adrenoceptors or imidazoline receptors?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

The defense reaction: a common denominator of coronary risk and blood pressure in neurogenic hypertension?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Localization of I2-imidazoline binding sites on monoamine oxidases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Alpha-2 adrenergic receptors. Immunohistochemical localization and role in mediating inhibition of adrenergic RVLM presympathetic neurons by catecholamines and clonidine

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Importance of imidazoline receptors in the cardiovascular actions of centrally acting antihypertensive agents

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

I1-imidazoline receptors. Definition, characterization, distribution, and transmembrane signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Functional studies of specific imidazoline-2 receptor ligands.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Excess catecholamines and the metabolic syndrome: should central imidazoline receptors be a therapeutic target?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Involvement of alpha 2-adrenoceptors in the cardiovascular effects of moxonidine

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Mechanisms involved in the hyperglycemic response induced by clonidine and other alpha-2 adrenoceptor agonists

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Characterization of alpha-adrenoceptors participating in the central hypotensive and sedative effects of clonidine using yohimbine, rauwolscine and corynanthine

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Reversal of clonidine-induced hypotension by β-adrenoceptor blocking drugs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

The central hyperglycaemic effect of clonidine

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Blockade of the central hypotensive effect of clonidine by alpha-adrenoreceptor and antagonists in rats, rabbits and dogs.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Evidence for antiserotonergic properties of yohimbine

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Central and peripheral effects of S 3341 [(N-dicyclopropylmethyl)-amino-2-oxazoline] in animal models

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Interruption of TPA-induced signals by an antiviral and antitumoral xanthate compound: inhibition of a phospholipase C-type reaction

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Circulating atrial natriuretic factor activates vagal afferent inputs to paraventriculo-spinal neurones in the rat.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Evidence for the involvement of imidazoline receptors in the central hypotensive effect of rilmenidine in the rabbit

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Binding of [3H]p-aminoclonidine to two sites, alpha 2-adrenoceptors and imidazoline binding sites: distribution of imidazoline binding sites in rat brain.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Role of imidazole receptors in the vasodepressor response to clonidine analogs in the rostral ventrolateral medulla.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Imidazole binding sites in rabbit kidney and forebrain membranes.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Role of ventrolateral medulla in sympatholytic effect of 8-OHDPAT in rats

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Effects of clonidine and other imidazole-receptor binding agents on second messenger systems and calcium influx in bovine adrenal chromaffin cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Rilmenidine lowers arterial pressure via imidazole receptors in brainstem C1 area.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

A comparison of the haemodynamic and behavioural effects of moxonidine and clonidine in normotensive subjects

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Yohimbine as a serotonergic agent: evidence from receptor binding and drug discrimination

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Factors determining the specificity of signal transduction by guanine nucleotide-binding protein-coupled receptors. III. Coupling of alpha 2-adrenergic receptor subtypes in a cell type-specific manner

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Role of the ventral surface of the brain stem in the hypotensive action of clonidine

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Sedative-hypnotic properties of a new benzodiazepine in comparison with flurazepam. Pharmacological and clinical findings

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

The interaction between prazosin and clonidine at α-adrenoceptors in rats and cats

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Pharmacological evidence for a central alpha-sympathomimetic mechanism controlling blood pressure and heart rate

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Central hypotensive effects of the alpha2a-adrenergic receptor subtype.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Moxonidine, a centrally acting antihypertensive agent, is a selective ligand for I1-imidazoline sites.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Dose-response effects of intravenous clonidine on stress response during induction of anesthesia in coronary artery bypass graft patients.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Effect of I1-imidazoline receptor activation on responses of hypoglossal and phrenic nerve to chemical stimulation.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Blood pressure via telemetry during social confrontations in rats: effects of clonidine.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Identification, localization and functional analysis of imidazoline and alpha adrenergic receptors in canine prostate.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Open-field behavior in two models of genetic hypertension and the behavioral effects of salt excess.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

The alpha 1- and alpha 2-adrenoceptor involvement in the central cardiovascular action of clonidine in the conscious renal hypertensive cat.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Dexmedetomidine produces a hypnotic-anesthetic action in rats via activation of central alpha-2 adrenoceptors

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Astrocytes cultured from specific brain regions differ in their expression of adrenergic binding sites.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1351308

Binding of [3H]cirazoline to an imidazoline site in rat brain and kidney membranes

28 October 2018

1 reference

12 December 2020

The imidazoline I1 receptor agonist, moxonidine, inhibits insulin secretion from isolated rat islets of Langerhans

1 reference

12 December 2020

Coupling of I1-imidazoline receptors to diacylglyceride accumulation in PC12 rat pheochromocytoma cells

1 reference

12 December 2020

Role of imidazoline receptors in the cardiovascular actions of moxonidine, rilmenidine and clonidine in conscious rabbits.

1 reference

12 December 2020

Effect of S-21663 (PMS 812), an imidazoline derivative, on glucose tolerance and insulin secretion in a rat model of type II diabetes

1 reference

12 December 2020

Sympathetic nervous system in salt-sensitive and obese hypertension: amelioration of multiple abnormalities by a central sympatholytic agent

1 reference

12 December 2020

Membrane localization and guanine nucleotide sensitivity of medullary I1-imidazoline binding sites

1 reference

12 December 2020

Induction of defective insulin secretion and impaired glucose tolerance by clonidine. Selective stimulation of metabolic alpha-adrenergic pathways

1 reference

12 December 2020

Agonist radioligands for identifying functional neurotransmitter receptors. Introduction

1 reference

12 December 2020

Crossover comparison of moxonidine and clonidine in mild to moderate hypertension

1 reference

12 December 2020

The blood pressure effects of alpha-adrenoceptor antagonists injected in the medullary site of action of clonidine: the nucleus reticularis lateralis

1 reference

12 December 2020

Clonidine binds to imidazole binding sites as well as alpha 2-adrenoceptors in the ventrolateral medulla

1 reference

12 December 2020

General pharmacology of the novel centrally acting antihypertensive agent moxonidine

1 reference

12 December 2020

The imidazoline preferring receptor: binding studies in bovine, rat and human brainstem

1 reference

12 December 2020

Differences in the ability of yohimbine to antagonize the hypotensive effect of clonidine in normotensive and spontaneously hypertensive anesthetized rats

1 reference

12 December 2020

Changes in serotonin metabolism in the rat raphe magnus and cardiovascular modifications following systemic administration of clonidine and other central alpha 2-agonists: an in vivo voltammetry study

1 reference

12 December 2020

5-Hydroxytryptamine 5-HT1B and 5-HT1D receptors mediating inhibition of adenylate cyclase activity. Pharmacological comparison with special reference to the effects of yohimbine, rauwolscine and some beta-adrenoceptor antagonists

1 reference

12 December 2020

Subcellular distribution of imidazoline-guanidinium-receptive sites in human and rabbit liver. Major localization to the mitochondrial outer membrane

1 reference

12 December 2020

Role of alpha 2-adrenergic receptors in the carotid body response to isocapnic hypoxia

1 reference

12 December 2020

Effects of clonidine on blood pressure and heart rate responses to an emotional stress in the rat: a spectral study

1 reference

12 December 2020

TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown

1 reference

12 December 2020

Tizanidine may discriminate between imidazoline-receptors and alpha 2-adrenoceptors

1 reference

12 December 2020

[3H]p-Aminoclonidine and [3H]idazoxan label different populations of imidazoline sites on rat kidney

1 reference

12 December 2020

Alpha 2-adrenergic, but not imidazole, agonists activate NaCl cotransport in rabbit tracheal epithelial cells

1 reference

12 December 2020

Hypotensive and bradycardic effects of talipexole (B-HT 920) in anaesthetized rabbits are antagonized by metoclopramide but not by yohimbine

1 reference

12 December 2020

Binding of [3H]clonidine to I1-imidazoline sites in bovine adrenal medullary membranes

1 reference

12 December 2020

Nonadrenergic imidazoline binding sites on human platelets

1 reference

12 December 2020

Refeeding hypertension in obese spontaneously hypertensive rats

1 reference

12 December 2020

Effects of moxonidine, an imidazoline antihypertensive agent, on second messenger systems in rat brain

1 reference

12 December 2020

Selective antihypertensive action of moxonidine is mediated mainly by I1-imidazoline receptors in the rostral ventrolateral medulla

1 reference

12 December 2020

Role of medullary I1-imidazoline and alpha 2-adrenergic receptors in the antihypertensive responses evoked by central administration of clonidine analogs in conscious spontaneously hypertensive rats

1 reference

12 December 2020

Regulation of phenylethanolamine N-methyltransferase gene expression by imidazoline receptors in adrenal chromaffin cells

1 reference

12 December 2020

Evidence for an alpha-sympathomimetic component in the effects of catapresan on vasomotor centres: antagonism by piperoxane

1 reference

12 December 2020

Action of -adrenergic blocking drugs on the sympathetic centres and their interactions with the central sympatho-inhibitory effect of clonidine

1 reference

12 December 2020

Optimization of radioligand binding assays for I1-imidazoline sites

1 reference

12 December 2020

Alpha 2 adrenoceptor- and imidazoline-preferring binding sites in the dog kidney

1 reference

12 December 2020

Differential characteristics and localisation of [3H]oxazoline and [3H]imidazoline binding sites in rat kidney

1 reference

12 December 2020

10.1097/00004872-199715011-00002

Identifiers

DOI

1 reference

1 August 2017

1 reference

1 August 2017

1 reference

PubMed ID

9050981