Evaluation of the therapeutic potential of a CNP analog in a Fgfr3 mouse model recapitulating achondroplasia (Q34314761)

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19 February 2020

title

Evaluation of the therapeutic potential of a CNP analog in a Fgfr3 mouse model recapitulating achondroplasia (English)

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19 February 2020

2

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Catherine Benoist-Lasselin

19 February 2020

4

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19 February 2020

Laurence Legeai-Mallet

15

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Arnold Munnich

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19 February 2020

author name string

Florence Lorget

1

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19 February 2020

Jeff Peng

3

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19 February 2020

Emilie Mugniery

5

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19 February 2020

Todd Oppeneer

6

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19 February 2020

Dan J Wendt

7

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19 February 2020

Sean M Bell

8

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19 February 2020

Sherry Bullens

9

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19 February 2020

Stuart Bunting

10

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19 February 2020

Laurie S Tsuruda

11

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19 February 2020

Charles A O'Neill

12

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19 February 2020

Federico Di Rocco

13

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19 February 2020

language of work or name

English

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publication date

29 November 2012

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American Journal of Human Genetics

19 February 2020

published in

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volume

91

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19 February 2020

issue

6

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19 February 2020

page(s)

1108-1114

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A novel tyrosine kinase inhibitor restores chondrocyte differentiation and promotes bone growth in a gain-of-function Fgfr3 mouse model

19 February 2020

cites work

1 reference

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Clinical management of achondroplasia

6 July 2018

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Genetic inactivation of ERK1 and ERK2 in chondrocytes promotes bone growth and enlarges the spinal canal

6 July 2018

1 reference

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Achondroplasia: pathogenesis and implications for future treatment

6 July 2018

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Systemic administration of C-type natriuretic peptide as a novel therapeutic strategy for skeletal dysplasias

6 July 2018

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Human immortalized chondrocytes carrying heterozygous FGFR3 mutations: an in vitro model to study chondrodysplasias

6 July 2018

1 reference

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C-type natriuretic peptide regulates endochondral bone growth through p38 MAP kinase-dependent and -independent pathways

6 July 2018

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Fibroblast growth factor expression in the postnatal growth plate

6 July 2018

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Interaction of fibroblast growth factor and C-natriuretic peptide signaling in regulation of chondrocyte proliferation and extracellular matrix homeostasis

6 July 2018

1 reference

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Complementary antagonistic actions between C-type natriuretic peptide and the MAPK pathway through FGFR-3 in ATDC5 cells

6 July 2018

1 reference

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A loss-of-function mutation in natriuretic peptide receptor 2 (Npr2) gene is responsible for disproportionate dwarfism in cn/cn mouse

6 July 2018

1 reference

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Mutations in the transmembrane natriuretic peptide receptor NPR-B impair skeletal growth and cause acromesomelic dysplasia, type Maroteaux

6 July 2018

1 reference

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Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516592

Overexpression of FGFR3, Stat1, Stat5 and p21Cip1 correlates with phenotypic severity and defective chondrocyte differentiation in FGFR3-related chondrodysplasias

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516592

Dwarfism and early death in mice lacking C-type natriuretic peptide

6 July 2018

1 reference

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A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors

6 July 2018

1 reference

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Natriuretic peptide regulation of endochondral ossification. Evidence for possible roles of the C-type natriuretic peptide/guanylyl cyclase-B pathway.

6 July 2018

1 reference

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Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism

6 July 2018

1 reference

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Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3.

6 July 2018

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Fibroblast growth factor receptor 3 is a negative regulator of bone growth

6 July 2018

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Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia

6 July 2018

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Activating Fgfr3 Y367C mutation causes hearing loss and inner ear defect in a mouse model of chondrodysplasia

6 July 2018

1 reference

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Overexpression of the C-type natriuretic peptide (CNP) is associated with overgrowth and bone anomalies in an individual with balanced t(2;7) translocation.

28 October 2018

1 reference

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Concentration of mRNA for the natriuretic peptide receptor-C in hypertrophic chondrocytes of the fetal mouse tibia.

28 October 2018

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Regulation of fetal rat bone growth by C-type natriuretic peptide and cGMP.

28 October 2018

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Bioactivity and metabolism of C-type natriuretic peptide in normal man

28 October 2018

1 reference

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Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia

28 October 2018

1 reference

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Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway

28 October 2018

1 reference

PubMed

12 December 2020

Fibroblast growth factor receptor 3 mutations promote apoptosis but do not alter chondrocyte proliferation in thanatophoric dysplasia

1 reference

PubMed

12 December 2020

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12 December 2020

A cluster of translocation breakpoints in 2q37 is associated with overexpression of NPPC in patients with a similar overgrowth phenotype

1 reference

PubMed

12 December 2020

10.1016/J.AJHG.2012.10.014

Identifiers

DOI

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19 February 2020

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19 February 2020

PubMed publication ID

23200862

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