The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells (Q34315871)

1 August 2017

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title

The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells (English)

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1 August 2017

4

Pieter Wesseling

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1 August 2017

5

Gosse J Adema

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1 August 2017

Dennis Lindau

1

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1 August 2017

Paul Gielen

series ordinal

2

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1 August 2017

Michiel Kroesen

series ordinal

3

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1 August 2017

publication date

1 February 2013

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1 August 2017

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1 August 2017

volume

138

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1 August 2017

issue

2

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1 August 2017

page(s)

105-115

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Immune therapy for cancer

1 August 2017

cites work

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Sipuleucel-T immunotherapy for castration-resistant prostate cancer

21 January 2018

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Route of administration of the TLR9 agonist CpG critically determines the efficacy of cancer immunotherapy in mice

21 January 2018

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Targeted delivery of TLR ligands to human and mouse dendritic cells strongly enhances adjuvanticity

21 January 2018

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Hallmarks of Cancer: The Next Generation

21 January 2018

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Natural innate and adaptive immunity to cancer

21 January 2018

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Targeting natural killer cells and natural killer T cells in cancer

21 January 2018

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Profound Coordinated Alterations of Intratumoral NK Cell Phenotype and Function in Lung Carcinoma

21 January 2018

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Regulatory T cells in melanoma: the final hurdle towards effective immunotherapy?

21 January 2018

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Regulatory T cells and the PD-L1/PD-1 pathway mediate immune suppression in malignant human brain tumors.

21 January 2018

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CD8+ Foxp3+ regulatory T cells mediate immunosuppression in prostate cancer

21 January 2018

1 reference

Tumor-evoked regulatory B cells promote breast cancer metastasis by converting resting CD4⁺ T cells to T-regulatory cells

21 January 2018

1 reference

CD1d-expressing breast cancer cells modulate NKT cell-mediated antitumor immunity in a murine model of breast cancer metastasis

21 January 2018

1 reference

Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors.

21 January 2018

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FOXO3 programs tumor-associated DCs to become tolerogenic in human and murine prostate cancer

21 January 2018

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Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

21 January 2018

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Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN

21 January 2018

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Myeloid-derived suppressor cells as regulators of the immune system

21 January 2018

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Coordinated regulation of myeloid cells by tumours

21 January 2018

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Chronic inflammation promotes myeloid-derived suppressor cell activation blocking antitumor immunity in transgenic mouse melanoma model

21 January 2018

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HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

21 January 2018

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IL4Ralpha+ myeloid-derived suppressor cell expansion in cancer patients.

21 January 2018

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All-trans-retinoic acid improves differentiation of myeloid cells and immune response in cancer patients

21 January 2018

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Distinct signatures of the immune responses in low risk versus high risk neuroblastoma

21 January 2018

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Antigen-specific inhibition of CD8+ T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species.

21 January 2018

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Subsets of myeloid-derived suppressor cells in tumor-bearing mice

21 January 2018

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Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes

21 January 2018

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Hierarchy of immunosuppressive strength among myeloid-derived suppressor cell subsets is determined by GM-CSF.

21 January 2018

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Elevated myeloid-derived suppressor cells in pancreatic, esophageal and gastric cancer are an independent prognostic factor and are associated with significant elevation of the Th2 cytokine interleukin-13.

21 January 2018

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Myeloid-derived suppressor cell accumulation and function in patients with newly diagnosed glioblastoma

21 January 2018

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Tumor-derived G-CSF facilitates neoplastic growth through a granulocytic myeloid-derived suppressor cell-dependent mechanism

21 January 2018

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Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity

21 January 2018

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Transcriptomic analysis comparing tumor-associated neutrophils with granulocytic myeloid-derived suppressor cells and normal neutrophils

21 January 2018

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Myeloid-derived suppressor cell measurements in fresh and cryopreserved blood samples

21 January 2018

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Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor.

21 January 2018

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S100A9 a new marker for monocytic human myeloid-derived suppressor cells.

21 January 2018

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Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cells

21 January 2018

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Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer

21 January 2018

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Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice

21 January 2018

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Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells.

21 January 2018

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Regulation of T cell receptor CD3zeta chain expression by L-arginine

21 January 2018

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Cancer-expanded myeloid-derived suppressor cells induce anergy of NK cells through membrane-bound TGF-beta 1.

21 January 2018

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Expansion of spleen myeloid suppressor cells represses NK cell cytotoxicity in tumor-bearing host

21 January 2018

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Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor.

21 January 2018

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Regulation of NK cell function by human granulocyte arginase

21 January 2018

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Induction of anti-glioma natural killer cell response following multiple low-dose intracerebral CpG therapy

21 January 2018

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Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

21 January 2018

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Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors

21 January 2018

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Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferation

21 January 2018

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Oligodeoxynucleotides stabilize Helios-expressing Foxp3+ human T regulatory cells during in vitro expansion

21 January 2018

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CD80 in immune suppression by mouse ovarian carcinoma-associated Gr-1+CD11b+ myeloid cells

21 January 2018

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Gr-1+CD115+ Immature Myeloid Suppressor Cells Mediate the Development of Tumor-Induced T Regulatory Cells and T-Cell Anergy in Tumor-Bearing Host

21 January 2018

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Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells

21 January 2018

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Immune stimulatory receptor CD40 is required for T-cell suppression and T regulatory cell activation mediated by myeloid-derived suppressor cells in cancer

21 January 2018

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Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells

21 January 2018

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Expression of Helios in Peripherally Induced Foxp3+ Regulatory T Cells

21 January 2018

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Helios expression is a marker of T cell activation and proliferation.

21 January 2018

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Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo

21 January 2018

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Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells

21 January 2018

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Elimination of regulatory T cells is essential for an effective vaccination with tumor lysate-pulsed dendritic cells in a murine glioma model

21 January 2018

1 reference

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

21 January 2018

1 reference

Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates

21 January 2018

1 reference

The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies

21 January 2018

1 reference

In situ stimulation of CD40 and Toll-like receptor 3 transforms ovarian cancer-infiltrating dendritic cells from immunosuppressive to immunostimulatory cells

21 January 2018

1 reference

PD-1/PD-L1 interactions contribute to functional T-cell impairment in patients who relapse with cancer after allogeneic stem cell transplantation.

21 January 2018

1 reference

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

21 January 2018

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Safety, activity, and immune correlates of anti-PD-1 antibody in cancer

21 January 2018

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CD1 recognition by mouse NK1+ T lymphocytes

21 January 2018

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Recognition of bacterial glycosphingolipids by natural killer T cells

21 January 2018

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Defective NKT cell activation by CD1d+ TRAMP prostate tumor cells is corrected by interleukin-12 with α-galactosylceramide.

21 January 2018

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Cross-regulation between type I and type II NKT cells in regulating tumor immunity: a new immunoregulatory axis

21 January 2018

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Activation of natural killer T cells by alpha-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a coadministered protein

21 January 2018

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Inflammation-associated lysophospholipids as ligands for CD1d-restricted T cells in human cancer

21 January 2018

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TGF-beta downregulates the activating receptor NKG2D on NK cells and CD8+ T cells in glioma patients

21 January 2018

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Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: abrogation prevents tumor recurrence.

21 January 2018

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The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells

21 January 2018

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Activated NKT cells and NK cells render T cells resistant to myeloid-derived suppressor cells and result in an effective adoptive cellular therapy against breast cancer in the FVBN202 transgenic mouse.

21 January 2018

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Valpha24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages

21 January 2018

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Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A

21 January 2018

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Neutrophilic granulocytes modulate invariant NKT cell function in mice and humans

21 January 2018

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CD1d-restricted T cells regulate dendritic cell function and antitumor immunity in a granulocyte-macrophage colony-stimulating factor-dependent fashion

21 January 2018

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Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans

21 January 2018

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A reversible defect in natural killer T cell function characterizes the progression of premalignant to malignant multiple myeloma

21 January 2018

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Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy

21 January 2018

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Distinct myeloid suppressor cell subsets correlate with plasma IL-6 and IL-10 and reduced interferon-alpha signaling in CD4⁺ T cells from patients with GI malignancy

21 January 2018

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Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival

21 January 2018

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Sunitinib reverses type-1 immune suppression and decreases T-regulatory cells in renal cell carcinoma patients

21 January 2018

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Sorafenib, but not sunitinib, affects function of dendritic cells and induction of primary immune responses

21 January 2018

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Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients

21 January 2018

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The restoration of myeloid-derived suppressor cells as functional antigen-presenting cells by NKT cell help and all-trans-retinoic acid treatment

21 January 2018

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CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans

21 January 2018

1 reference

Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists

21 January 2018

1 reference

Intratumoral injection of CpG oligonucleotides induces the differentiation and reduces the immunosuppressive activity of myeloid-derived suppressor cells

21 January 2018

1 reference

Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer.

21 January 2018

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Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia

21 January 2018

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Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion

21 January 2018

1 reference

PubMed Central

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575763

Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of t-cell function in advanced cancer patients.

28 October 2018

1 reference

PubMed Central

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575763

Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody.

28 October 2018

1 reference

PubMed Central

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575763

Dendritic Cell Vaccination in Combination with Anti-CD25 Monoclonal Antibody Treatment: A Phase I/II Study in Metastatic Melanoma Patients

28 October 2018

1 reference

Increased Level of both CD4+FOXP3+ Regulatory T Cells and CD14+HLA-DR−/low Myeloid-Derived Suppressor Cells and Decreased Level of Dendritic Cells in Patients with Multiple Myeloma

21 January 2018

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MIP-2 recruits NKT cells to the spleen during tolerance induction

21 January 2018

1 reference

12 December 2020

NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway

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12 December 2020

Low levels of circulating invariant natural killer T cells predict poor clinical outcome in patients with head and neck squamous cell carcinoma

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12 December 2020

Identification of a New Subset of Myeloid Suppressor Cells in Peripheral Blood of Melanoma Patients With Modulation by a Granulocyte-Macrophage Colony-Stimulation Factor–Based Antitumor Vaccine

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12 December 2020

Immunosuppressive myeloid-derived suppressor cells can be converted into immunogenic APCs with the help of activated NKT cells: an alternative cell-based antitumor vaccine

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12 December 2020

Immature immunosuppressive CD14+HLA-DR-/low cells in melanoma patients are Stat3hi and overexpress CD80, CD83, and DC-sign

1 reference

12 December 2020

Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes

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12 December 2020

CpG blocks immunosuppression by myeloid-derived suppressor cells in tumor-bearing mice

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12 December 2020

Identifiers

DOI

10.1111/IMM.12036

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1 August 2017

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