IL-7 signaling must be intermittent, not continuous, during CD8⁺ T cell homeostasis to promote cell survival instead of cell death (Q34317840)

1 August 2017

title

IL-7 signaling must be intermittent, not continuous, during CD8⁺ T cell homeostasis to promote cell survival instead of cell death (English)

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1 August 2017

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Motoko Y Kimura

1

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1 August 2017

Leonid A Pobezinsky

2

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1 August 2017

Terry I Guinter

3

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1 August 2017

Julien Thomas

4

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1 August 2017

Anthony Adams

5

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1 August 2017

Jung-Hyun Park

6

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1 August 2017

Xuguang Tai

7

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1 August 2017

Alfred Singer

8

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1 August 2017

language of work or name

English

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publication date

16 December 2012

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1 August 2017

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1 August 2017

volume

14

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1 August 2017

issue

2

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1 August 2017

page(s)

143-151

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Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells

1 August 2017

cites work

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T cell receptor-dependent regulation of lipid rafts controls naive CD8+ T cell homeostasis

6 July 2018

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Naive T cell homeostasis: from awareness of space to a sense of place

6 July 2018

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Self-class I MHC molecules support survival of naive CD8 T cells, but depress their functional sensitivity through regulation of CD8 expression levels

6 July 2018

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New insights into the regulation of T cells by gamma(c) family cytokines

6 July 2018

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Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor.

6 July 2018

1 reference

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Homeostasis of naive and memory T cells

6 July 2018

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IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival

6 July 2018

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6 July 2018

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Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model

6 July 2018

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Cell biology of IL-7, a key lymphotrophin

6 July 2018

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IL-7 receptor signals inhibit expression of transcription factors TCF-1, LEF-1, and RORgammat: impact on thymocyte development.

6 July 2018

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A distal region in the interferon-gamma gene is a site of epigenetic remodeling and transcriptional regulation by interleukin-2.

6 July 2018

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Death of peripheral CD8+ T cells in the absence of MHC class I is Fas-dependent and not blocked by Bcl-xL.

6 July 2018

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Regulation of peripheral T-cell homeostasis by receptor signalling

6 July 2018

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Interferon gamma is required for activation-induced death of T lymphocytes

6 July 2018

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IL-7 is critical for homeostatic proliferation and survival of naive T cells

6 July 2018

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How alpha beta T cells deal with induced TCR alpha ablation

6 July 2018

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Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma.

6 July 2018

1 reference

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Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

6 July 2018

1 reference

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Transient inhibition of interleukin 4 signaling by T cell receptor ligation

6 July 2018

1 reference

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Interferon gamma eliminates responding CD4 T cells during mycobacterial infection by inducing apoptosis of activated CD4 T cells

6 July 2018

1 reference

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6 July 2018

1 reference

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Inhibition of interleukin 2 signaling and signal transducer and activator of transcription (STAT)5 activation during T cell receptor-mediated feedback inhibition of T cell expansion

6 July 2018

1 reference

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The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552087

Apoptotic regulation of T cells and absence of immune deficiency in virus-infected gamma interferon receptor knockout mice

6 July 2018

1 reference

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Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552087

Functional cleavage of the common cytokine receptor gamma chain (gammac) by calpain

6 July 2018

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Differential requirements for survival and proliferation of CD8 naïve or memory T cells

6 July 2018

1 reference

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Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain

6 July 2018

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Interferon gamma plays a critical role in induced cell death of effector T cell: a possible third mechanism of self-tolerance

6 July 2018

1 reference

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'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR.

6 July 2018

1 reference

Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity.

21 January 2018

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Interferon‐γ induces reactive oxygen species and endoplasmic reticulum stress at the hepatic apoptosis

21 January 2018

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Oxidative stress induces PKR-dependent apoptosis via IFN-gamma activation signaling in Jurkat T cells

21 January 2018

1 reference

IFN-gamma-STAT1 signal regulates the differentiation of inducible Treg: potential role for ROS-mediated apoptosis

21 January 2018

1 reference

MHC class I is required for peripheral accumulation of CD8+ thymic emigrants.

21 January 2018

1 reference

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Suppression of IL7Rα Transcription by IL-7 and Other Prosurvival Cytokines

28 October 2018

1 reference

T lymphocytes need IL-7 but not IL-4 or IL-6 to survive in vivo

21 January 2018

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12 December 2020

Role of IRF-1 and caspase-7 in IFN-gamma enhancement of Fas-mediated apoptosis in ACHN renal cell carcinoma cells

1 reference

12 December 2020

IL-7 transgenic mice: analysis of the role of IL-7 in the differentiation of thymocytes in vivo and in vitro

1 reference

12 December 2020

IL-7-induced proliferation of recent thymic emigrants requires activation of the PI3K pathway

1 reference

12 December 2020

Identifiers

DOI

10.1038/NI.2494

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1 August 2017

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1 August 2017

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