Recent lessons learned from prevention and recent-onset type 1 diabetes immunotherapy trials (Q34318993)

1 August 2017

5 references

14 March 2019

24 March 2019

30 June 2019

25 June 2019

9 September 2020

Recent lessons learned from prevention and recent-onset type 1 diabetes immunotherapy trials (English)

1 reference

1 August 2017

4 references

14 March 2019

24 March 2019

30 June 2019

25 June 2019

2 references

9 September 2020

1 reference

1 reference

2

Lucienne Chatenoud

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author name string

Teodora P Staeva

series ordinal

1

1 reference

1 August 2017

Richard Insel

series ordinal

3

1 reference

1 August 2017

Mark A Atkinson

series ordinal

4

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1 August 2017

language of work or name

English

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publication date

1 January 2013

6 references

1 August 2017

14 March 2019

24 March 2019

30 June 2019

25 June 2019

9 September 2020

9

1 reference

inferred from page(s)

published in

Diabetes

6 references

1 August 2017

14 March 2019

24 March 2019

30 June 2019

25 June 2019

9 September 2020

62

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1 August 2017

1

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1 August 2017

9-17

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Creative Commons Attribution-NonCommercial-NoDerivatives

1 August 2017

4 references

14 March 2019

24 March 2019

30 June 2019

25 June 2019

on focus list of Wikimedia project

ScienceSource

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cites work

Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function

1 reference

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Fall in C-peptide during first 2 years from diagnosis: evidence of at least two distinct phases from composite Type 1 Diabetes TrialNet data

6 July 2018

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Synergistic reversal of type 1 diabetes in NOD mice with anti-CD3 and interleukin-1 blockade: evidence of improved immune regulation

6 July 2018

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A historical view from thirty eventful years of immunotherapy in autoimmune diabetes

6 July 2018

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Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial

6 July 2018

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Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial

6 July 2018

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Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial

6 July 2018

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Validation of the Diabetes Prevention Trial-Type 1 Risk Score in the TrialNet Natural History Study

6 July 2018

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Persistence is the twin sister of excellence: an important lesson for attempts to prevent and reverse type 1 diabetes

6 July 2018

1 reference

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Stopping type 1 diabetes: attempts to prevent or cure type 1 diabetes in man.

6 July 2018

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The pancreas in human type 1 diabetes

6 July 2018

1 reference

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Genetics, pathogenesis and clinical interventions in type 1 diabetes

6 July 2018

1 reference

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Blockade of interleukin 1 in type 1 diabetes mellitus

6 July 2018

1 reference

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Immune depletion with cellular mobilization imparts immunoregulation and reverses autoimmune diabetes in nonobese diabetic mice

6 July 2018

1 reference

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Etanercept treatment in children with new-onset type 1 diabetes: pilot randomized, placebo-controlled, double-blind study

6 July 2018

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C-peptide levels and insulin independence following autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus

6 July 2018

1 reference

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The role of inflammation in insulitis and beta-cell loss in type 1 diabetes

6 July 2018

1 reference

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Expansion of human regulatory T-cells from patients with type 1 diabetes

6 July 2018

1 reference

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Human regulatory T cells: role in autoimmune disease and therapeutic opportunities

6 July 2018

1 reference

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Modulating the natural history of type 1 diabetes in children at high genetic risk by mucosal insulin immunization

6 July 2018

1 reference

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CD3-specific antibodies: a portal to the treatment of autoimmunity

6 July 2018

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Translational mini-review series on type 1 diabetes: Immune-based therapeutic approaches for type 1 diabetes

6 July 2018

1 reference

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Regulatory T-cell physiology and application to treat autoimmunity

6 July 2018

1 reference

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Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526042

Granulocyte colony-stimulating factor: a novel mediator of T cell tolerance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526042

A comprehensive review of interventions in the NOD mouse and implications for translation

6 July 2018

1 reference

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Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes

6 July 2018

1 reference

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A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526042

Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526042

Type 1 diabetes: new perspectives on disease pathogenesis and treatment

6 July 2018

1 reference

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Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy

6 July 2018

1 reference

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Determinant spreading of T helper cell 2 (Th2) responses to pancreatic islet autoantigens

6 July 2018

1 reference

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Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes

6 July 2018

1 reference

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Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice

6 July 2018

1 reference

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Effects of Cyclosporine Immunosuppression in Insulin-Dependent Diabetes Mellitus of Recent Onset

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526042

Cyclosporin increases the rate and length of remissions in insulin-dependent diabetes of recent onset. Results of a multicentre double-blind trial.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526042

Antigen-driven bystander suppression after oral administration of antigens

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526042

Cyclosporine in recent onset type I diabetes mellitus. Effects on islet beta cell function. Miami Cyclosporine Diabetes Study Group

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526042

GAD65 antigen therapy in recently diagnosed type 1 diabetes mellitus.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526042

Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526042

TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526042

Early determinants of type 1 diabetes: experience from the BABYDIAB and BABYDIET studies

28 October 2018

1 reference

12 December 2020

Cyclosporin-induced remission of IDDM after early intervention. Association of 1 yr of cyclosporin treatment with enhanced insulin secretion. The Canadian-European Randomized Control Trial Group

1 reference

12 December 2020

Follow-up of cyclosporin A treatment in type 1 (insulin-dependent) diabetes mellitus: lack of long-term effects

1 reference

12 December 2020

Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients

1 reference

12 December 2020

Orally induced bystander suppression in experimental autoimmune uveoretinitis occurs only in the periphery and not in the eye

1 reference

12 December 2020

Induction of glutamic acid decarboxylase 65-specific Th2 cells and suppression of autoimmune diabetes at late stages of disease is epitope dependent

1 reference

12 December 2020

Treatment with granulocyte colony-stimulating factor prevents diabetes in NOD mice by recruiting plasmacytoid dendritic cells and functional CD4(+)CD25(+) regulatory T-cells

1 reference

12 December 2020

Identifiers

DOI

10.2337/DB12-0562

1 reference

1 August 2017

1 reference

1 August 2017

1 reference