Unconventional miR-122 binding stabilizes the HCV genome by forming a trimolecular RNA structure (Q34328215)

1 August 2017

Unconventional miR-122 binding stabilizes the HCV genome by forming a trimolecular RNA structure (English)

1 reference

1 August 2017

2

Jennifer A Doudna

1 reference

1 August 2017

Stefanie A Mortimer

1

1 reference

PubMed ID

23416544

1 August 2017

language of work or name

English

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publication date

14 February 2013

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1 August 2017

Nucleic Acids Research

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1 August 2017

41

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1 August 2017

7

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1 August 2017

4230-4240

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Creative Commons Attribution-NonCommercial 3.0 Unported

1 August 2017

start time

4 October 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Competing and noncompeting activities of miR-122 and the 5' exonuclease Xrn1 in regulation of hepatitis C virus replication.

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The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC.

6 July 2018

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Base pairing between hepatitis C virus RNA and microRNA 122 3' of its seed sequence is essential for genome stabilization and production of infectious virus.

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627571

Structure of a hepatitis C virus RNA domain in complex with a translation inhibitor reveals a binding mode reminiscent of riboswitches

6 July 2018

1 reference

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Stabilization of hepatitis C virus RNA by an Ago2-miR-122 complex.

6 July 2018

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Structural map of a microRNA-122: hepatitis C virus complex

6 July 2018

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Crystal structure of the HCV IRES central domain reveals strategy for start-codon positioning

6 July 2018

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Novel therapies for hepatitis C: insights from the structure of the virus

6 July 2018

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Dual regulation of hepatitis C viral RNA by cellular RNAi requires partitioning of Ago2 to lipid droplets and P-bodies

6 July 2018

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miR-122 activates hepatitis C virus translation by a specialized mechanism requiring particular RNA components

6 July 2018

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Coupled 5′ Nucleotide Recognition and Processivity in Xrn1-Mediated mRNA Decay

6 July 2018

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Masking the 5' terminal nucleotides of the hepatitis C virus genome by an unconventional microRNA-target RNA complex.

6 July 2018

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Human Ago2 is required for efficient microRNA 122 regulation of hepatitis C virus RNA accumulation and translation.

6 July 2018

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High-throughput SHAPE and hydroxyl radical analysis of RNA structure and ribonucleoprotein assembly

6 July 2018

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The HCV IRES pseudoknot positions the initiation codon on the 40S ribosomal subunit

6 July 2018

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Regulation of hepatitis C virus translation and infectious virus production by the microRNA miR-122

6 July 2018

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Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection

6 July 2018

1 reference

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Modulation of hepatitis C virus RNA abundance and the isoprenoid biosynthesis pathway by microRNA miR-122 involves distinct mechanisms

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627571

Time-resolved RNA SHAPE chemistry: quantitative RNA structure analysis in one-second snapshots and at single-nucleotide resolution

6 July 2018

1 reference

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MicroRNAs: target recognition and regulatory functions

6 July 2018

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microRNA-122 stimulates translation of hepatitis C virus RNA

6 July 2018

1 reference

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Position-dependent function for a tandem microRNA miR-122-binding site located in the hepatitis C virus RNA genome

6 July 2018

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LNA-mediated microRNA silencing in non-human primates

6 July 2018

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Cellular cofactors affecting hepatitis C virus infection and replication

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627571

Studying Hepatitis C Virus: Making the Best of a Bad Virus

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627571

A fast-acting reagent for accurate analysis of RNA secondary and tertiary structure by SHAPE chemistry

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627571

miR-122, a mammalian liver-specific microRNA, is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627571

miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting

6 July 2018

1 reference

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Silencing of microRNAs in vivo with 'antagomirs'

6 July 2018

1 reference

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Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627571

Analysis of the 5' end structure of HCV subgenomic RNA replicated in a Huh7 cell line

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627571

RNA structure analysis at single nucleotide resolution by selective 2'-hydroxyl acylation and primer extension (SHAPE)

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627571

Structure of HCV IRES domain II determined by NMR

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627571

Hepatitis C virus IRES RNA-induced changes in the conformation of the 40s ribosomal subunit

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627571

In vitro translation using HeLa extract

6 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093%2FNAR%2FGKT075

Structure of the hepatitis C virus IRES bound to the human 80S ribosome: remodeling of the HCV IRES.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093%2FNAR%2FGKT075

21 January 2018

Identifiers

DOI

10.1093/NAR/GKT075

1 reference

1 August 2017

1 reference

1 August 2017

1 reference

PubMed ID

23416544