Improved ex vivo expansion of adult hematopoietic stem cells by overcoming CUL4-mediated degradation of HOXB4. (Q34334720)

1 August 2017

Improved ex vivo expansion of adult hematopoietic stem cells by overcoming CUL4-mediated degradation of HOXB4. (English)

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1 August 2017

Jennifer Lee

1

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1 August 2017

Jae-Hung Shieh

2

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1 August 2017

Jianxuan Zhang

3

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1 August 2017

Liren Liu

4

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1 August 2017

Yue Zhang

5

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1 August 2017

Jae Yong Eom

6

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1 August 2017

Giovanni Morrone

7

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1 August 2017

Malcolm A S Moore

8

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1 August 2017

Pengbo Zhou

9

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1 August 2017

language of work or name

English

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publication date

21 March 2013

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1 August 2017

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1 August 2017

121

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1 August 2017

20

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1 August 2017

4082-4089

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Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis

1 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656448

HOXC4 homeoprotein efficiently expands human hematopoietic stem cells and triggers similar molecular alterations as HOXB4

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656448

Ex vivo expansion of human hematopoietic stem and progenitor cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656448

Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656448

Hematopoietic stem cell transplantation: a global perspective

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656448

CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656448

Expansion of haematopoietic stem cells from normal donors and bone marrow failure patients by recombinant hoxb4.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656448

High incidence of leukemia in large animals after stem cell gene therapy with a HOXB4-expressing retroviral vector

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656448

Enforced expression of NUP98-HOXA9 in human CD34(+) cells enhances stem cell proliferation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656448

A kinase-independent function of c-Abl in promoting proteolytic destruction of damaged DNA binding proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656448

Endosome disruption enhances the functional nuclear delivery of Tat-fusion proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656448

CUL-4A stimulates ubiquitylation and degradation of the HOXA9 homeodomain protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656448

Structure of HoxA9 and Pbx1 bound to DNA: Hox hexapeptide and DNA recognition anterior to posterior

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656448

Occurrence of leukaemia following gene therapy of X-linked SCID.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656448

Protein transduction: unrestricted delivery into all cells?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656448

Enhanced in vivo regenerative potential of HOXB4-transduced hematopoietic stem cells with regulation of their pool size

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656448

Enforced expression of HOXB7 promotes hematopoietic stem cell proliferation and myeloid-restricted progenitor differentiation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656448

Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656448

Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656448

Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656448

Direct evidence for ex vivo expansion of human hematopoietic stem cells.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656448

In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656448

Gene therapy. Seeking the cause of induced leukemias in X-SCID trial

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656448

A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656448

HOXB4-induced expansion of adult hematopoietic stem cells ex vivo.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656448

Ex vivo expansion of human hematopoietic stem cells by direct delivery of the HOXB4 homeoprotein

27 October 2018

1 reference

12 December 2020

Elevated telomerase activity and minimal telomere loss in cord blood long-term cultures with extensive stem cell replication

1 reference

12 December 2020

Recombinant HoxB4 fusion proteins enhance hematopoietic differentiation of human embryonic stem cells

1 reference

12 December 2020

Purified recombinant TAT-homeobox B4 expands CD34(+) umbilical cord blood and peripheral blood progenitor cells ex vivo

1 reference

12 December 2020

10.1182/BLOOD-2012-09-455204

Identifiers

DOI

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1 August 2017

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1 August 2017

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