Ligand-induced conformational shift in the N-terminal domain of GRP94, an Hsp90 chaperone (Q34338453)

1 August 2017

Ligand-induced conformational shift in the N-terminal domain of GRP94, an Hsp90 chaperone (English)

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1 August 2017

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Robert M Immormino

1

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1 August 2017

D Eric Dollins

2

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1 August 2017

Paul L Shaffer

3

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1 August 2017

Karen L Soldano

4

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1 August 2017

Melissa A Walker

5

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1 August 2017

Daniel T Gewirth

6

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1 August 2017

language of work or name

English

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publication date

2 August 2004

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Journal of Biological Chemistry

1 August 2017

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1 August 2017

279

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1 August 2017

44

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1 August 2017

46162-46171

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Structure, function, and mechanism of the Hsp90 molecular chaperone

1 August 2017

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https://api.crossref.org/works/10.1074%2FJBC.M405253200

The 90-kDa molecular chaperone family: structure, function, and clinical applications. A comprehensive review

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M405253200

Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M405253200

In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M405253200

Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M405253200

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M405253200

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M405253200

The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M405253200

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M405253200

Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405253200

The hsp90-binding antibiotic geldanamycin decreases Raf levels and epidermal growth factor signaling without disrupting formation of signaling complexes or reducing the specific enzymatic activity of Raf kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405253200

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405253200

Progesterone receptor structure and function altered by geldanamycin, an hsp90-binding agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405253200

Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M405253200

Hsp90-mediated folding of the lymphoid cell kinase p56lck

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M405253200

GHKL, an emergent ATPase/kinase superfamily

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M405253200

Crystal structure of an N-terminal fragment of the DNA gyrase B protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405253200

Transformation of MutL by ATP binding and hydrolysis: a switch in DNA mismatch repair

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M405253200

The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domains

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M405253200

Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405253200

Regulation of heat shock protein 90 ATPase activity by sequences in the carboxyl terminus

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M405253200

Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M405253200

Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405253200

Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405253200

MOLREP: an Automated Program for Molecular Replacement

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405253200

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405253200

Improved methods for building protein models in electron density maps and the location of errors in these models

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M405253200

Structure validation by Calpha geometry: phi,psi and Cbeta deviation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M405253200

New tools and data for improving structures, using all-atom contacts

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M405253200

ATPase domain of eukaryotic DNA topoisomerase II. Inhibition of ATPase activity by the anti-cancer drug bisdioxopiperazine and ATP/ADP-induced dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405253200

Identification of structural motifs from protein coordinate data: secondary structure and first-level supersecondary structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405253200

The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405253200

A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405253200

Dimerization of Escherichia coli DNA-gyrase B provides a structural mechanism for activating the ATPase catalytic center

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M405253200

Adenosine nucleotides and the regulation of GRP94-client protein interactions

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M405253200

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M405253200

Dimerization and N-terminal domain proximity underlie the function of the molecular chaperone heat shock protein 90

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M405253200

The charged region of Hsp90 modulates the function of the N-terminal domain

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M405253200

N-terminal residues regulate the catalytic efficiency of the Hsp90 ATPase cycle

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M405253200

Sequential interaction of the chaperones BiP and GRP94 with immunoglobulin chains in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405253200

21 January 2018

Identifiers

DOI

10.1074/JBC.M405253200

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1 August 2017

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