Mouse-adapted H9N2 influenza A virus PB2 protein M147L and E627K mutations are critical for high virulence (Q34342367)

1 August 2017

Mouse-adapted H9N2 influenza A virus PB2 protein M147L and E627K mutations are critical for high virulence (English)

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1 August 2017

influenza A virus

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Jingjing Wang

1

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1 August 2017

Yipeng Sun

2

1 reference

1 August 2017

Qi Xu

3

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1 August 2017

Yuanyuan Tan

4

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1 August 2017

Juan Pu

5

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1 August 2017

Hanchun Yang

6

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1 August 2017

Earl G Brown

7

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1 August 2017

Jinhua Liu

8

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1 August 2017

language of work or name

English

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publication date

10 July 2012

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1 August 2017

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1 August 2017

7

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1 August 2017

7

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1 August 2017

e40752

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Creative Commons Attribution 4.0 International

1 August 2017

start time

10 July 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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The polymerase acidic protein gene of influenza a virus contributes to pathogenicity in a mouse model

6 July 2018

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Adaptive mutations resulting in enhanced polymerase activity contribute to high virulence of influenza A virus in mice

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6 July 2018

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PB2 protein of a highly pathogenic avian influenza virus strain A/chicken/Yamaguchi/7/2004 (H5N1) determines its replication potential in pigs

6 July 2018

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6 July 2018

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6 July 2018

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H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice.

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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PB2 amino acid at position 627 affects replicative efficiency, but not cell tropism, of Hong Kong H5N1 influenza A viruses in mice

6 July 2018

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Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease?

6 July 2018

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Cocirculation of avian H9N2 and contemporary "human" H3N2 influenza A viruses in pigs in southeastern China: potential for genetic reassortment?

6 July 2018

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Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses

6 July 2018

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Pattern of mutation in the genome of influenza A virus on adaptation to increased virulence in the mouse lung: identification of functional themes

6 July 2018

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Inhibition of interferon-mediated antiviral responses by influenza A viruses and other negative-strand RNA viruses

6 July 2018

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Avian-to-human transmission of H9N2 subtype influenza A viruses: relationship between H9N2 and H5N1 human isolates.

6 July 2018

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A DNA transfection system for generation of influenza A virus from eight plasmids

6 July 2018

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Molecular basis for the generation in pigs of influenza A viruses with pandemic potential

6 July 2018

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Virulence of influenza A virus for mouse lung

6 July 2018

1 reference

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A single amino acid in the PB2 gene of influenza A virus is a determinant of host range.

6 July 2018

1 reference

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The influenza virus variant A/FM/1/47-MA possesses single amino acid replacements in the hemagglutinin, controlling virulence, and in the matrix protein, controlling virulence as well as growth.

6 July 2018

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Pathogenicity of influenza virus

6 July 2018

1 reference

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Studies on the genetic determinants of influenza virus pathogenicity for mice with the use of reassortants between mouse-adapted and non-adapted variants of the same virus strain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393695

Studies on the genetic basis of human influenza A virus adaptation to mice: degrees of virulence of reassortants with defined genetic content

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393695

The Pathogenesis of Infections of the Mouse Caused by Virulent and Avirulent Variants of an Influenza Virus

6 July 2018

1 reference

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Effects of low- and high-passage influenza virus infection in normal and nude mice

6 July 2018

1 reference

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Variability of NS1 proteins among H9N2 avian influenza viruses isolated in Israel during 2000-2009.

6 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0040752

Phylogenetic analysis of influenza A viruses (H6N8, H1N8, H4N2, H9N2, H10N7) isolated from wild birds, ducks, and ostriches in South Africa from 2007 to 2009.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0040752

H9N2 influenza A viruses from poultry in Asia have human virus-like receptor specificity

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0040752

Antibodies against H5 and H9 avian influenza among poultry workers in China

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0040752

Multiple amino acid substitutions are involved in the adaptation of H9N2 avian influenza virus to mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0040752

Genetic analysis of mouse-adapted influenza A virus identifies roles for the NA, PB1, and PB2 genes in virulence

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0040752

10.1371/JOURNAL.PONE.0040752

21 January 2018

Identifiers

DOI

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1 August 2017

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1 August 2017

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