A trypanothione-dependent glyoxalase I with a prokaryotic ancestry in Leishmania major (Q34343348)

1 August 2017

title

A trypanothione-dependent glyoxalase I with a prokaryotic ancestry in Leishmania major (English)

1 reference

trypanothione-dependent glyoxalase I

1 August 2017

main subject

1 reference

GeneDB

trypanothione-dependent glyoxalase I

6 February 2019

0 references

0 references

1 reference

Alan H Fairlamb

3

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Tim J. Vickers

series ordinal

1

object named as

Tim J Vickers

1 reference

1 August 2017

2

Neil Greig

1 reference

1 August 2017

language of work or name

English

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publication date

25 August 2004

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1 August 2017

number of pages

6

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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1 August 2017

volume

101

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1 August 2017

issue

36

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1 August 2017

page(s)

13186-13191

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Glyoxalase II of African trypanosomes is trypanothione-dependent

1 August 2017

cites work

1 reference

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6 July 2018

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Leishmaniasis--current chemotherapy and recent advances in the search for novel drugs

6 July 2018

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6 July 2018

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Plant-like traits associated with metabolism of Trypanosoma parasites

6 July 2018

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Yeast glyoxalase I is a monomeric enzyme with two active sites

6 July 2018

1 reference

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Determination of the structure of Escherichia coli glyoxalase I suggests a structural basis for differential metal activation

6 July 2018

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Structure-activity study on the in vitro antiprotozoal activity of glutathione derivatives

6 July 2018

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Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue

6 July 2018

1 reference

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Active monomeric and dimeric forms of Pseudomonas putida glyoxalase I: evidence for 3D domain swapping.

6 July 2018

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Pharmacology of methylglyoxal: formation, modification of proteins and nucleic acids, and enzymatic detoxification--a role in pathogenesis and antiproliferative chemotherapy.

6 July 2018

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Optimized heterologous expression of the human zinc enzyme glyoxalase I

6 July 2018

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6 July 2018

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Inhibition of proliferation of human leukaemia 60 cells by methylglyoxal in vitro

6 July 2018

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S-(N-aryl-N-hydroxycarbamoyl)glutathione derivatives are tight-binding inhibitors of glyoxalase I and slow substrates for glyoxalase II.

6 July 2018

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Reversal of the reaction catalyzed by glyoxalase I. Calculation of the equilibrium constant for the enzymatic reaction.

6 July 2018

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DNA-damaging activity of biotic and xenobiotic aldehydes in Chinese hamster ovary cells

6 July 2018

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Metabolism of methylglyoxal in microorganisms

6 July 2018

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Cancerostatic action of methylglyoxal

6 July 2018

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Kinetic evaluation of substrate specificity in the glyoxalase-I-catalyzed disproportionation of α-ketoaldehydes

6 July 2018

1 reference

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6 July 2018

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Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids

6 July 2018

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6 July 2018

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D-lactate production by Leishmania braziliensis through the glyoxalase pathway

6 July 2018

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Caution: the glycylmethyl and glycylethyl esters of glutathione are substrates for glyoxalase I

6 July 2018

1 reference

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Glyoxalase I, a zinc metalloenzyme of mammals and yeast

6 July 2018

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Effect of pH and thiols on the kinetics of yeast glyoxalase I. Evaluation of the random pathway mechanism

6 July 2018

1 reference

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An XAS investigation of product and inhibitor complexes of Ni-containing GlxI from Escherichia coli: mechanistic implications

6 July 2018

1 reference

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Overproduction and characterization of a dimeric non-zinc glyoxalase I from Escherichia coli: evidence for optimal activation by nickel ions

21 January 2018

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Antimalarial activity in vitro of the glyoxalase I inhibitor diester, S-p-bromobenzylglutathione diethyl ester.

21 January 2018

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A rapid assay for the glyoxalase enzyme system

21 January 2018

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Ovothiol and trypanothione as antioxidants in trypanosomatids

21 January 2018

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A 33-kDa allergen from rice (Oryza sativa L. Japonica). cDNA cloning, expression, and identification as a novel glyoxalase I.

21 January 2018

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Inhibition of glyoxalase I by S-substituted glutathiones

21 January 2018

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12 December 2020

A comparative study of D-lactate, L-lactate and glycerol formation by four species of Leishmania and by Trypanosoma lewisi and Trypanosoma brucei gambiense

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12 December 2020

Methylglyoxal-catabolizing enzymes of Leishmania donovani promastigotes

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12 December 2020

Binding and modification of proteins by methylglyoxal under physiological conditions. A kinetic and mechanistic study with N alpha-acetylarginine, N alpha-acetylcysteine, and N alpha-acetyllysine, and bovine serum albumin

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12 December 2020

Improved method for the determination of blood glutathione

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12 December 2020

Identifiers

DOI

10.1073/PNAS.0402918101

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1 August 2017

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1 August 2017

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