Plasminogen kringle 5 induces apoptosis of brain microvessel endothelial cells: sensitization by radiation and requirement for GRP78 and LRP1. (Q34344454)

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English	Plasminogen kringle 5 induces apoptosis of brain microvessel endothelial cells: sensitization by radiation and requirement for GRP78 and LRP1.	scientific article

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scholarly article

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Europe PubMed Central

1 August 2017

Plasminogen kringle 5 induces apoptosis of brain microvessel endothelial cells: sensitization by radiation and requirement for GRP78 and LRP1. (English)

1 reference

Europe PubMed Central

1 August 2017

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based on heuristic

inferred from title

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Candece L Gladson

7

object named as

Candece L Gladson

1 reference

Europe PubMed Central

1 August 2017

author name string

Braden C McFarland

1

1 reference

Europe PubMed Central

1 August 2017

Jerry Stewart

2

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Europe PubMed Central

1 August 2017

Amal Hamza

3

1 reference

Europe PubMed Central

1 August 2017

Robert Nordal

4

1 reference

Europe PubMed Central

1 August 2017

Donald J Davidson

5

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Europe PubMed Central

1 August 2017

Jack Henkin

6

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Europe PubMed Central

1 August 2017

language of work or name

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publication date

23 June 2009

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Europe PubMed Central

1 August 2017

Cancer Research

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Europe PubMed Central

1 August 2017

69

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Europe PubMed Central

1 August 2017

13

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Europe PubMed Central

1 August 2017

5537-5545

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Europe PubMed Central

1 August 2017

Thrombospondin-1-induced apoptosis of brain microvascular endothelial cells can be mediated by TNF-R1

1 reference

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6 July 2018

Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells

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6 July 2018

GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosis

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6 July 2018

The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas.

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6 July 2018

GRP78 induction in cancer: therapeutic and prognostic implications.

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6 July 2018

Kringle 5 of human plasminogen, an angiogenesis inhibitor, induces both autophagy and apoptotic death in endothelial cells

1 reference

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Stress proteins and initiation of immune response: chaperokine activity of hsp72.

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Radiation combined with antiangiogenic and antivascular agents

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The p38 mitogen-activated protein kinase pathway in interferon signal transduction

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Apoptotic signaling pathways: caspases and stress-activated protein kinases

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The role of pericytes in blood-vessel formation and maintenance

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Plasminogen kringle 5-engineered glioma cells block migration of tumor-associated macrophages and suppress tumor vascularization and progression

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6 July 2018

Angiogenesis and radiation response modulation after vascular endothelial growth factor receptor-2 (VEGFR2) blockade

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6 July 2018

Platelet-derived growth factor receptor-beta (PDGFR-beta) activation promotes its association with the low density lipoprotein receptor-related protein (LRP). Evidence for co-receptor function

1 reference

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6 July 2018

Kringle 5 of human plasminogen induces apoptosis of endothelial and tumor cells through surface-expressed glucose-regulated protein 78.

1 reference

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Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK

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p27Kip1 and cyclin D1 are necessary for focal adhesion kinase regulation of cell cycle progression in glioblastoma cells propagated in vitro and in vivo in the scid mouse brain

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Targeted molecular therapy for malignant gliomas

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6 July 2018

Protein folding and quality control in the endoplasmic reticulum

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Diverse role of LDL receptor-related protein in the clearance of proteases and in signaling

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Low density lipoprotein receptor-related protein is a calreticulin coreceptor that signals focal adhesion disassembly

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The WHO classification of tumors of the nervous system

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6 July 2018

Platelet-derived growth factor mediates tyrosine phosphorylation of the cytoplasmic domain of the low Density lipoprotein receptor-related protein in caveolae

1 reference

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6 July 2018

Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function betwenn LRP and the PDGF.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990683

6 July 2018

LRP: a multifunctional scavenger and signaling receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990683

6 July 2018

Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction

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Eradication of murine mammary adenocarcinoma through HSVtk expression directed by the glucose-starvation inducible grp78 promoter.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990683

6 July 2018

Kringle 5 of plasminogen is a novel inhibitor of endothelial cell growth

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Increased expression of low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor in human malignant astrocytomas.

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6 July 2018

Ligation of integrin alpha5beta1 is required for internalization of vitronectin by integrin alphavbeta3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990683

6 July 2018

The 39-kDa receptor-associated protein modulates lipoprotein catabolism by binding to LDL receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2990683

6 July 2018

Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine

1 reference

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6 July 2018

Increased expression of the glucose-regulated gene encoding the Mr 78,000 glucose-regulated protein in chemically and radiation-transformed C3H 10T1/2 mouse embryo cells.

1 reference

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6 July 2018

Lyn kinase activity is the predominant cellular SRC kinase activity in glioblastoma tumor cells.

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27 October 2018

The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress

1 reference

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27 October 2018

Anginex synergizes with radiation therapy to inhibit tumor growth by radiosensitizing endothelial cells.

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27 October 2018

p38 MAPK mediates gamma-irradiation-induced endothelial cell apoptosis, and vascular endothelial growth factor protects endothelial cells through the phosphoinositide 3-kinase-Akt-Bcl-2 pathway

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27 October 2018

Intravitreal injection of plasminogen kringle 5, an endogenous angiogenic inhibitor, arrests retinal neovascularization in rats

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27 October 2018

Up-Regulation of Bcl-2 in microvascular endothelial cells enhances intratumoral angiogenesis and accelerates tumor growth

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12 December 2020

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The role of Grp 78 in alpha 2-macroglobulin-induced signal transduction. Evidence from RNA interference that the low density lipoprotein receptor-related protein is associated with, but not necessary for, GRP 78-mediated signal transduction

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https://pubmed.ncbi.nlm.nih.gov/19549899

12 December 2020

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Thrombospondin signaling through the calreticulin/LDL receptor-related protein co-complex stimulates random and directed cell migration

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https://pubmed.ncbi.nlm.nih.gov/19549899

12 December 2020

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The Voltage-dependent Anion Channel Is a Receptor for Plasminogen Kringle 5 on Human Endothelial Cells

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12 December 2020

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Kringle 5 causes cell cycle arrest and apoptosis of endothelial cells

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https://pubmed.ncbi.nlm.nih.gov/19549899

12 December 2020

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Effective gene-virotherapy for complete eradication of tumor mediated by the combination of hTRAIL (TNFSF10) and plasminogen k5

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12 December 2020

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Combination of human plasminogen kringle 5 with ionizing radiation significantly enhances the efficacy of antitumor effect

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https://pubmed.ncbi.nlm.nih.gov/19549899

12 December 2020

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Attachment of primary neonatal rat astrocytes to vitronectin is mediated by integrins alphavbeta5 and alpha8beta1: modulation by the type 1 plasminogen activator inhibitor

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12 December 2020

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Identifiers

10.1158/0008-5472.CAN-08-4841

1 reference

Europe PubMed Central

1 August 2017

1 reference

Europe PubMed Central

1 August 2017

1 reference

Europe PubMed Central

1 August 2017

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