Epstein-Barr virus (EBV) LMP2A mediates B-lymphocyte survival through constitutive activation of the Ras/PI3K/Akt pathway (Q34347586)

1 August 2017

Epstein-Barr virus (EBV) LMP2A mediates B-lymphocyte survival through constitutive activation of the Ras/PI3K/Akt pathway (English)

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1 August 2017

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2

Richard Longnecker

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1 August 2017

Toni Portis

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PubMed ID

15361852

1 August 2017

language of work or name

English

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publication date

1 November 2004

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1 August 2017

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1 August 2017

23

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53

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1 August 2017

8619-8628

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1207905

1 August 2017

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Epstein-Barr virus LMP2A-induced B-cell survival in two unique classes of EmuLMP2A transgenic mice

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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

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Epstein-Barr virus latent membrane protein 2A regulates c-Jun protein through extracellular signal-regulated kinase

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Epstein-Barr virus latent membrane protein 2A (LMP2A) employs the SLP-65 signaling module

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Latent membrane protein 2A inhibits transforming growth factor-beta 1-induced apoptosis through the phosphatidylinositol 3-kinase/Akt pathway

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bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice.

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Inactivation of Bcl-2 by phosphorylation

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Bcl-2 phosphorylation required for anti-apoptosis function

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The LMP2A ITAM is essential for providing B cells with development and survival signals in vivo

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Ras mediates effector pathways responsible for pre-B cell survival, which is essential for the developmental progression to the late pre-B cell stage

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Epstein-Barr virus LMP2A interferes with global transcription factor regulation when expressed during B-lymphocyte development

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Epstein-Barr virus LMP2A transforms epithelial cells, inhibits cell differentiation, and activates Akt.

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Latent membrane protein 2A-mediated effects on the phosphatidylinositol 3-Kinase/Akt pathway

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Blocking oncogenic Ras signaling for cancer therapy

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7 January 2021

EBV persistence in memory B cells in vivo.

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7 January 2021

MEK inhibitor U0126 interferes with immunofluorescence analysis of apoptotic cell death

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7 January 2021

Epstein-Barr virus latent gene transcription in nasopharyngeal carcinoma cells: coexpression of EBNA1, LMP1, and LMP2 transcripts

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7 January 2021

An Epstein-Barr virus transformation-associated membrane protein interacts with src family tyrosine kinases

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Epstein-Barr virus LMP2A drives B cell development and survival in the absence of normal B cell receptor signals

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Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.

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Ras signalling and apoptosis

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Frequent aberrant immunoglobulin gene rearrangements in pro-B cells revealed by a bcl-xL transgene.

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The immunoreceptor tyrosine-based activation motif of Epstein-Barr virus LMP2A is essential for blocking BCR-mediated signal transduction

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7 January 2021

Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.

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7 January 2021

Basal B-cell receptor signaling in B lymphocytes: mechanisms of regulation and role in positive selection, differentiation, and peripheral survival

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7 January 2021

Control of B cell development by Ras-mediated activation of Raf.

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7 January 2021

Biology of Hodgkin's lymphoma

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LMP2A survival and developmental signals are transmitted through Btk-dependent and Btk-independent pathways

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7 January 2021

Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases

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Mechanisms of selection mediated by interleukin-7, the preBCR, and hemokinin-1 during B-cell development

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Requirement for B cell linker protein (BLNK) in B cell development

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7 January 2021

The LMP2A signalosome--a therapeutic target for Epstein-Barr virus latency and associated disease

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7 January 2021

Epstein-Barr Virus (EBV) LMP2A induces alterations in gene transcription similar to those observed in Reed-Sternberg cells of Hodgkin lymphoma

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7 January 2021

Induction of Ig light chain gene rearrangement in heavy chain-deficient B cells by activated Ras.

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7 January 2021

Activated Ras signals developmental progression of recombinase-activating gene (RAG)-deficient pro-B lymphocytes

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7 January 2021

PKB/AKT: functional insights from genetic models

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7 January 2021

JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis

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7 January 2021

Role of phosphatidylinositol 3-kinase and specific protein kinase B isoforms in the suppression of apoptosis mediated by the Abelson protein-tyrosine kinase

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7 January 2021

Epstein-Barr virus: exploiting the immune system

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7 January 2021

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

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7 January 2021

BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

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7 January 2021

Epstein-Barr virus and oncogenesis: from latent genes to tumours

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207905

1 reference

PubMed ID

15361852

Dimensions Publication ID

1 August 2017

0 references

1 reference

PubMed ID

15361852