A human iPSC model of Ligase IV deficiency reveals an important role for NHEJ-mediated-DSB repair in the survival and genomic stability of induced pluripotent stem cells and emerging haematopoietic progenitors. (Q34347694)

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English	A human iPSC model of Ligase IV deficiency reveals an important role for NHEJ-mediated-DSB repair in the survival and genomic stability of induced pluripotent stem cells and emerging haematopoietic progenitors.	scientific article

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2 March 2020

A human iPSC model of Ligase IV deficiency reveals an important role for NHEJ-mediated-DSB repair in the survival and genomic stability of induced pluripotent stem cells and emerging haematopoietic progenitors (English)

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2 March 2020

Human Induced Pluripotent Stem Cells

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2 March 2020

Inmaculada Moreno-Gimeno

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2 March 2020

Gabriele Saretzki

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2 March 2020

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2 March 2020

14

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2 March 2020

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2 March 2020

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K Tilgner

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2 March 2020

J Y Al-Aama

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2 March 2020

D Burks

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2 March 2020

S Yung

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2 March 2020

C Singhapol

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2 March 2020

J Evans

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2 March 2020

A Gennery

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2 March 2020

S Przyborski

12

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2 March 2020

M Stojkovic

13

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2 March 2020

P Jeggo

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2 March 2020

publication date

31 May 2013

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2 March 2020

Cell Death & Differentiation

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2 March 2020

20

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2 March 2020

8

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2 March 2020

1089-1100

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2 March 2020

SCL/TAL1 regulates hematopoietic specification from human embryonic stem cells

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Efficient stage-specific differentiation of human pluripotent stem cells toward retinal photoreceptor cells.

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Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage

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6 July 2018

Large-scale transcriptional profiling and functional assays reveal important roles for Rho-GTPase signalling and SCL during haematopoietic differentiation of human embryonic stem cells

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6 July 2018

Requirement for DNA ligase IV during embryonic neuronal development

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6 July 2018

Human induced pluripotent cells resemble embryonic stem cells demonstrating enhanced levels of DNA repair and efficacy of nonhomologous end-joining

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6 July 2018

Error-prone nonhomologous end joining repair operates in human pluripotent stem cells during late G2.

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6 July 2018

Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair

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6 July 2018

Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture

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6 July 2018

Regulation of DNA strand exchange in homologous recombination

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6 July 2018

Actin-Myosin Contractility Is Responsible for the Reduced Viability of Dissociated Human Embryonic Stem Cells

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6 July 2018

Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis

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6 July 2018

Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome

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6 July 2018

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6 July 2018

Mechanisms of double-strand break repair in somatic mammalian cells

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6 July 2018

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

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6 July 2018

Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome.

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6 July 2018

Altered hematopoiesis in mice lacking DNA polymerase mu is due to inefficient double-strand break repair

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6 July 2018

Mouse but not human embryonic stem cells are deficient in rejoining of ionizing radiation-induced DNA double-strand breaks

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6 July 2018

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

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6 July 2018

DNA repair is limiting for haematopoietic stem cells during ageing

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Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures

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6 July 2018

XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining

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An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome

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6 July 2018

Genetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombination

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6 July 2018

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Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells

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6 July 2018

A patient with mutations in DNA Ligase IV: clinical features and overlap with Nijmegen breakage syndrome.

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Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells.

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Identification and Classification of Chromosomal Aberrations in Human Induced Pluripotent Stem Cells

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21 January 2018

Brief report: human pluripotent stem cell models of fanconi anemia deficiency reveal an important role for fanconi anemia proteins in cellular reprogramming and survival of hematopoietic progenitors.

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21 January 2018

Analysis of DNA double-strand break (DSB) repair in mammalian cells.

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A backup DNA repair pathway moves to the forefront

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12 December 2020

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Expression and functional analysis of G1 to S regulatory components reveals an important role for CDK2 in cell cycle regulation in human embryonic stem cells

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12 December 2020

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Human induced pluripotent stem cell lines show stress defense mechanisms and mitochondrial regulation similar to those of human embryonic stem cells

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12 December 2020

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High resolution array-CGH characterization of human stem cells using a stem cell focused microarray

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12 December 2020

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Recurrent copy number variations in human induced pluripotent stem cells

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Ligase IV Syndrome

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7 January 2021

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10.1038/CDD.2013.44

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2 March 2020

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2 March 2020

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2 March 2020

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