A systematic review of the safety and efficacy of mesenchymal stem cells for disc degeneration: insights and future directions for regenerative therapeutics (Q34360743)

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English	A systematic review of the safety and efficacy of mesenchymal stem cells for disc degeneration: insights and future directions for regenerative therapeutics	scientific article

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scholarly article

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Europe PubMed Central

1 August 2017

A systematic review of the safety and efficacy of mesenchymal stem cells for disc degeneration: insights and future directions for regenerative therapeutics (English)

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Europe PubMed Central

1 August 2017

mesenchymal stem cell

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based on heuristic

inferred from title

systematic review

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based on heuristic

inferred from title

2

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13 June 2020

Victor Y L Leung

5

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13 June 2020

Kenneth M Cheung

6

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13 June 2020

author name string

Rita Lok-Hay Yim

1

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13 June 2020

Cora H Bow

3

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13 June 2020

Björn Meij

4

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13 June 2020

Patrick Vavken

7

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13 June 2020

Dino Samartzis

8

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13 June 2020

language of work or name

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publication date

11 September 2014

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Stem Cells and Development

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13 June 2020

23

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13 June 2020

21

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13 June 2020

2553-2567

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13 June 2020

The paracrine effects of mesenchymal stem cells stimulate the regeneration capacity of endogenous stem cells in the repair of a bladder-outlet-obstruction-induced overactive bladder

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

6 July 2018

Fatal immune hemolytic anemia following allogeneic stem cell transplantation: report of 2 cases and review of literature.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

6 July 2018

Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

6 July 2018

Degenerative magnetic resonance imaging changes in patients with chronic low back pain: a systematic review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

6 July 2018

Emerging technologies for molecular therapy for intervertebral disk degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

6 July 2018

Gene therapy for intervertebral disk degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

6 July 2018

Management of degenerative disk disease and chronic low back pain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

6 July 2018

Porcine intervertebral disc repair using allogeneic juvenile articular chondrocytes or mesenchymal stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

6 July 2018

Intervertebral disc repair by autologous mesenchymal bone marrow cells: a pilot study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

6 July 2018

Autologous stem cell therapy maintains vertebral blood flow and contrast diffusion through the endplate in experimental intervertebral disc degeneration

1 reference

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6 July 2018

Degeneration and regeneration of the intervertebral disc: lessons from development

1 reference

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6 July 2018

Intradiscal transplantation of synovial mesenchymal stem cells prevents intervertebral disc degeneration through suppression of matrix metalloproteinase-related genes in nucleus pulposus cells in rabbits.

1 reference

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6 July 2018

Structured coculture of stem cells and disc cells prevent disc degeneration in a rat model

1 reference

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6 July 2018

Toward an understanding of the role of notochordal cells in the adult intervertebral disc: from discord to accord

1 reference

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6 July 2018

Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement

1 reference

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6 July 2018

Intervertebral disc repair using adipose tissue-derived stem and regenerative cells: experiments in a canine model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

6 July 2018

Mesenchymal stem cells arrest intervertebral disc degeneration through chondrocytic differentiation and stimulation of endogenous cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

6 July 2018

Human mesenchymal stem cells implantation into the degenerated coccygeal disc of the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

6 July 2018

Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

6 July 2018

Biological repair of the degenerated intervertebral disc by the injection of growth factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

6 July 2018

Distinct intervertebral disc cell populations adopt similar phenotypes in three-dimensional culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

6 July 2018

Effect of severity of intervertebral disc injury on mesenchymal stem cell-based regeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

6 July 2018

Complications and reoperations of the SB Charité lumbar disc prosthesis: experience in 75 patients

1 reference

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6 July 2018

Pathophysiology of the intervertebral disc and the challenges for MRI.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

6 July 2018

Clinical experience in cell-based therapeutics: disc chondrocyte transplantation A treatment for degenerated or damaged intervertebral disc

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

6 July 2018

What is intervertebral disc degeneration, and what causes it?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

6 July 2018

Nonsurgical management of acute and chronic low back pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

6 July 2018

Regeneration of intervertebral disc by mesenchymal stem cells: potentials, limitations, and future direction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

6 July 2018

Molecular phenotypes of notochordal cells purified from immature nucleus pulposus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

6 July 2018

Growth factors and treatment of intervertebral disc degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

6 July 2018

Low back pain: pathophysiology and management

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

6 July 2018

Degeneration of the intervertebral disc

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

6 July 2018

The relationship between facet joint osteoarthritis and disc degeneration of the lumbar spine: an MRI study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

6 July 2018

Assessing the quality of reports of randomized clinical trials: is blinding necessary?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

6 July 2018

Nutrition of the intervertebral disc: effect of fluid flow on solute transport

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

6 July 2018

Swelling pressure of the lumbar intervertebral discs: influence of age, spinal level, composition, and degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

6 July 2018

Descriptive epidemiology of low-back pain and its related medical care in the United States.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

6 July 2018

Magnetic resonance study of disc degeneration in young low-back pain patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

6 July 2018

Mid- to long-term results of total lumbar disc replacement: a prospective analysis with 5- to 10-year follow-up.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

27 October 2018

Comparison of spinal fusion and nonoperative treatment in patients with chronic low back pain: long-term follow-up of three randomized controlled trials.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

27 October 2018

The dog as an animal model for intervertebral disc degeneration?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

27 October 2018

Transplantation of mesenchymal stem cells and nucleus pulposus cells in a degenerative disc model in rabbits: a comparison of 2 cell types as potential candidates for disc regeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

27 October 2018

Effect of cell number on mesenchymal stem cell transplantation in a canine disc degeneration model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

27 October 2018

Transplanted mesenchymal stem cells with pure fibrinous gelatin-transforming growth factor-beta1 decrease rabbit intervertebral disc degeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

27 October 2018

The association between lumbar disc degeneration and low back pain: the influence of age, gender, and individual radiographic features

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

27 October 2018

Transplantation of mesenchymal stem cells in a canine disc degeneration model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

27 October 2018

Feasibility of a stem cell therapy for intervertebral disc degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

27 October 2018

Narrowing of lumbar spinal canal predicts chronic low back pain more accurately than intervertebral disc degeneration: a magnetic resonance imaging study in young Finnish male conscripts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

27 October 2018

Differentiation of mesenchymal stem cells transplanted to a rabbit degenerative disc model: potential and limitations for stem cell therapy in disc regeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

27 October 2018

Regenerative effects of transplanting mesenchymal stem cells embedded in atelocollagen to the degenerated intervertebral disc

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

27 October 2018

Intradiscal administration of osteogenic protein-1 increases intervertebral disc height and proteoglycan content in the nucleus pulposus in normal adolescent rabbits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

27 October 2018

Intervertebral disc cell therapy for regeneration: mesenchymal stem cell implantation in rat intervertebral discs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

27 October 2018

Transplantation of mesenchymal stem cells embedded in Atelocollagen gel to the intervertebral disc: a potential therapeutic model for disc degeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4201280

27 October 2018

Bone mesenchymal stem cells transplanted into rabbit intervertebral discs can increase proteoglycans

1 reference

https://pubmed.ncbi.nlm.nih.gov/25050446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanical initiation of intervertebral disc degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/25050446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A population-based study of juvenile disc degeneration and its association with overweight and obesity, low back pain, and diminished functional status

1 reference

https://pubmed.ncbi.nlm.nih.gov/25050446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regeneration of intervertebral discs in a rat disc degeneration model by implanted adipose-tissue-derived stromal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25050446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morphologic changes in the lumbar intervertebral foramen due to flexion-extension, lateral bending, and axial rotation: an in vitro anatomic and biomechanical study

1 reference

https://pubmed.ncbi.nlm.nih.gov/25050446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transplantation of human mesenchymal stems cells into intervertebral discs in a xenogeneic porcine model

1 reference

https://pubmed.ncbi.nlm.nih.gov/25050446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The relationship between disc degeneration, facet joint osteoarthritis, and stability of the degenerative lumbar spine

1 reference

https://pubmed.ncbi.nlm.nih.gov/25050446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunoselected STRO-3+ mesenchymal precursor cells and restoration of the extracellular matrix of degenerate intervertebral discs

1 reference

https://pubmed.ncbi.nlm.nih.gov/25050446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Magnetic resonance imaging and low back pain in adults: a diagnostic imaging study of 40-year-old men and women

1 reference

https://pubmed.ncbi.nlm.nih.gov/25050446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-dependent correlation of low-back pain and lumbar disc regeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/25050446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mesenchymal stem cells injection in degenerated intervertebral disc: cell leakage may induce osteophyte formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/25050446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of implantation of bone marrow mesenchymal stem cells, disc distraction and combined therapy on reversing degeneration of the intervertebral disc

1 reference

https://pubmed.ncbi.nlm.nih.gov/25050446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevalence and pattern of lumbar magnetic resonance imaging changes in a population study of one thousand forty-three individuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/25050446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular therapy of the intervertebral disc

1 reference

https://pubmed.ncbi.nlm.nih.gov/25050446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Does Lumbar Disc Degeneration on Magnetic Resonance Imaging Associate With Low Back Symptom Severity in Young Finnish Adults?

1 reference

https://pubmed.ncbi.nlm.nih.gov/25050446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disc regeneration therapy using marrow mesenchymal cell transplantation: a report of two case studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/25050446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The fate of transplanted xenogeneic bone marrow-derived stem cells in rat intervertebral discs

1 reference

https://pubmed.ncbi.nlm.nih.gov/25050446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1089/SCD.2014.0203

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25050446%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25050446%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25050446%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

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