Whole-body pharmacokinetics of HDAC inhibitor drugs, butyric acid, valproic acid and 4-phenylbutyric acid measured with carbon-11 labeled analogs by PET. (Q34361155)

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English	Whole-body pharmacokinetics of HDAC inhibitor drugs, butyric acid, valproic acid and 4-phenylbutyric acid measured with carbon-11 labeled analogs by PET.	scientific article

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6 March 2020

Whole-body pharmacokinetics of HDAC inhibitor drugs, butyric acid, valproic acid and 4-phenylbutyric acid measured with carbon-11 labeled analogs by PET (English)

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6 March 2020

pharmacokinetics

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Jacob M. Hooker

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Joanna S. Fowler

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Colleen Shea

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Sung Won Kim

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Nicola Otto

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Khaing Win

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29 July 2013

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Nuclear Medicine and Biology

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6 March 2020

912-918

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6 March 2020

Drug treatment for spinal muscular atrophy types II and III

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The inhibition of histone deacetylases reduces the reinstatement of cocaine-seeking behavior in rats

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Combined treatment with the mood stabilizers lithium and valproate produces multiple beneficial effects in transgenic mouse models of Huntington's disease

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Sodium butyrate improves memory function in an Alzheimer's disease mouse model when administered at an advanced stage of disease progression

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Posttraining systemic administration of the histone deacetylase inhibitor sodium butyrate ameliorates aging-related memory decline in rats

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Histone H4 acetylation by immunohistochemistry and prognosis in newly diagnosed adult acute lymphoblastic leukemia (ALL) patients

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Effect of butyrate enemas on inflammation and antioxidant status in the colonic mucosa of patients with ulcerative colitis in remission.

1 reference

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Valproic acid in pregnancy: how much are we endangering the embryo and fetus?

1 reference

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3,3'-diindolylmethane enhances the efficacy of butyrate in colon cancer prevention through down-regulation of survivin

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HDAC2 negatively regulates memory formation and synaptic plasticity.

1 reference

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Reinvestigation of the synthesis and evaluation of [N-methyl-(11)C]vorozole, a radiotracer targeting cytochrome P450 aromatase

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6 July 2018

Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation: a review

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769509

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Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

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Recovery of learning and memory is associated with chromatin remodelling

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Pulsed-dosing with oral sodium phenylbutyrate increases hemoglobin F in a patient with sickle cell anemia.

1 reference

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A randomized, placebo-controlled, multicenter study of divalproex sodium extended release in the treatment of acute mania.

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The histone deacetylase (HDAC) inhibitor valproic acid as monotherapy or in combination with all-trans retinoic acid in patients with acute myeloid leukemia

1 reference

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Depletion of latent HIV-1 infection in vivo: a proof-of-concept study

1 reference

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6 July 2018

Treatment of spinal muscular atrophy by sodium butyrate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769509

6 July 2018

Butyrate inhibits inflammatory responses through NFkappaB inhibition: implications for Crohn's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769509

6 July 2018

Butyrate production from dietary fibre and protection against large bowel cancer in a rat model

1 reference

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6 July 2018

Induction of fetal hemoglobin production in subjects with sickle cell anemia by oral sodium phenylbutyrate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769509

6 July 2018

Effect of butyrate enemas on the colonic mucosa in distal ulcerative colitis

1 reference

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6 July 2018

Dose-dependent inhibition in plasma protein binding of valproic acid during continued treatment in guinea-pigs

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6 July 2018

Phenylbutyrate suppresses distinct skin reactions that are enhanced by blockade of epidermal growth factor receptor signaling.

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27 October 2018

Sodium phenylbutyrate ameliorates focal cerebral ischemic/reperfusion injury associated with comorbid type 2 diabetes by reducing endoplasmic reticulum stress and DNA fragmentation

1 reference

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27 October 2018

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Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model

1 reference

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Influence of valproic acid on outcome of high-grade gliomas in children.

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Clinical pharmacology of sodium butyrate in patients with acute leukemia

1 reference

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Plasma concentrations of sodium valproate: their clinical value

1 reference

https://pubmed.ncbi.nlm.nih.gov/23906667

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inferred from PubMed ID database lookup

Increased fetal hemoglobin production in patients receiving valproic acid for epilepsy

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human brain, plasma, and cerebrospinal fluid concentration of sodium valproate after 72 hours of therapy

1 reference

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inferred from PubMed ID database lookup

Valproic acid and augmentation of fetal hemoglobin in individuals with and without sickle cell disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23906667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

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based on heuristic

inferred from PubMed ID database lookup

Suppression of histone deacetylation in vivo and in vitro by sodium butyrate

1 reference

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1 reference

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inferred from PubMed ID database lookup

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10.1016/J.NUCMEDBIO.2013.06.007

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6 March 2020

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6 March 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23906667%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

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