Polyamines and cancer: old molecules, new understanding (Q34362757)

1 August 2017

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title

Polyamines and cancer: old molecules, new understanding (English)

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1 August 2017

Frank L. Meyskens, Jr.

series ordinal

2

object named as

Frank L Meyskens

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1 August 2017

Eugene W Gerner

1

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PubMed ID

15510159

1 August 2017

language of work or name

English

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publication date

1 October 2004

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1 August 2017

Nature Reviews Cancer

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1 August 2017

4

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1 August 2017

781-792

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1 August 2017

10

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https://scigraph.springernature.com/pub.10.1038/nrc1454

1 August 2017

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The ornithine decarboxylase gene is essential for cell survival during early murine development

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Identification of c-MYC as a target of the APC pathway

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Identification of target genes of oncogenic transcription factors

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The MYC oncogene as a cancer drug target

31 March 2020

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The ornithine decarboxylase gene is a transcriptional target of c-Myc

31 March 2020

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APC-dependent changes in expression of genes influencing polyamine metabolism, and consequences for gastrointestinal carcinogenesis, in the Min mouse

31 March 2020

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APC-dependent regulation of ornithine decarboxylase in human colon tumor cells

31 March 2020

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Co-operation between follicular ornithine decarboxylase and v-Ha-ras induces spontaneous papillomas and malignant conversion in transgenic skin

31 March 2020

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Suppression of polyamine catabolism by activated Ki-ras in human colon cancer cells

31 March 2020

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Cyclooxygenase-independent Induction of Apoptosis by Sulindac Sulfone Is Mediated by Polyamines in Colon Cancer

31 March 2020

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eIF4E expression in tumors: its possible role in progression of malignancies

31 March 2020

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Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene

31 March 2020

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The chemopreventive agent alpha-difluoromethylornithine blocks Ki-ras-dependent tumor formation and specific gene expression in Caco-2 cells

31 March 2020

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Healing of chronic gastric ulcerations by L-arginine. Role of nitric oxide, prostaglandins, gastrin and polyamines

31 March 2020

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Loss of intracellular putrescine pool-size regulation induces apoptosis

31 March 2020

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Putrescine activates oxidative stress dependent apoptotic death in ornithine decarboxylase overproducing mouse myeloma cells

31 March 2020

1 reference

alpha-difluoromethylornithine induces apoptosis as well as anti-angiogenesis in the inhibition of tumor growth and metastasis in a human gastric cancer model

31 March 2020

1 reference

Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme

31 March 2020

1 reference

The organization of tight junctions in epithelia: implications for mammary gland biology and breast tumorigenesis

31 March 2020

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Regulation of adherens junctions and epithelial paracellular permeability: a novel function for polyamines

31 March 2020

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Polyamines regulate gap junction communication in connexin 43-expressing cells

31 March 2020

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Transgenic mouse models for studies of the role of polyamines in normal, hypertrophic and neoplastic growth

31 March 2020

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Methyl glyoxal bis(guanylhydrazone) as a potent inhibitor of mammalian and yeast S-adenosylmethionine decarboxylases

31 March 2020

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Alpha-methyl ornithine, a potent competitive inhibitor of ornithine decarboxylase, blocks proliferation of rat hepatoma cells in culture

31 March 2020

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Analogues of ornithine as inhibitors of ornithine decarboxylase. New deductions concerning the topography of the enzyme's active site

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Human trypanosomiasis in the Ivory Coast: therapy and problems

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Thirty Years of Polyamine-Related Approaches to Cancer Therapy. Retrospect and Prospect. Part 1. Selective Enzyme Inhibitors

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Ornithine decarboxylase as an enzyme target for therapy

31 March 2020

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alpha-Difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits tumor promoter-induced polyamine accumulation and carcinogenesis in mouse skin

31 March 2020

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Effect of alpha-difluoromethylornithine on rectal mucosal levels of polyamines in a randomized, double-blinded trial for colon cancer prevention

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Effects of difluoromethylornithine chemoprevention on audiometry thresholds and otoacoustic emissions

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Randomized phase I chemoprevention dose-seeking study of alpha-difluoromethylornithine

31 March 2020

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Alpha-difluoromethylornithine and polyamine levels in the human prostate: results of a phase IIa trial

31 March 2020

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Dose de-escalation chemoprevention trial of alpha-difluoromethylornithine in patients with colon polyps

31 March 2020

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Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)

31 March 2020

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A randomised, double blind, placebo controlled study of celecoxib, a selective cyclooxygenase 2 inhibitor, on duodenal polyposis in familial adenomatous polyposis

31 March 2020

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Polyamines reverse non-steroidal anti-inflammatory drug-induced toxicity in human colorectal cancer cells

31 March 2020

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Enhancement of regression of cervical intraepithelial neoplasia II (moderate dysplasia) with topically applied all-trans-retinoic acid: a randomized trial

31 March 2020

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Prevention of second primary tumors with isotretinoin in squamous-cell carcinoma of the head and neck

31 March 2020

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Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study

31 March 2020

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Stable ornithine decarboxylase in a rat hepatoma cell line selected for resistance to alpha-difluoromethylornithine

31 March 2020

1 reference

Ornithine decarboxylase is important in intestinal mucosal maturation and recovery from injury in rats

31 March 2020

1 reference

Intestinal changes caused by DL-alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase

31 March 2020

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H+/base transport in principal cells characterized by confocal fluorescence imaging

31 March 2020

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Polyamines and ornithine decarboxylase during repair of duodenal mucosa after stress in rats

31 March 2020

1 reference

Cellular disposition of transported polyamines in hypoxic rat lung and pulmonary arteries

31 March 2020

1 reference

Decarboxylation of ornithine and adenosymethionine in rat ovary during pregnancy

31 March 2020

1 reference

Ornithine decarboxylase activity and polyamine content of the placenta and decidual tissue in the rat

31 March 2020

1 reference

Altered levels of growth-related and novel gene transcripts in reproductive and other tissues of female mice overexpressing spermidine/spermine N1-acetyltransferase (SSAT).

31 March 2020

1 reference

Overexpression of antizyme in the hearts of transgenic mice prevents the isoprenaline-induced increase in cardiac ornithine decarboxylase activity and polyamines, but does not prevent cardiac hypertrophy.

31 March 2020

1 reference

Hypusine is essential for eukaryotic cell proliferation.

31 March 2020

1 reference

Translation initiation factor 5A and its hypusine modification are essential for cell viability in the yeast Saccharomyces cerevisiae

31 March 2020

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Eukaryotic initiation factor 5A activity and HIV-1 Rev function

31 March 2020

1 reference

A single amino acid substitution in yeast eIF-5A results in mRNA stabilization

31 March 2020

1 reference

Reading two bases twice: mammalian antizyme frameshifting in yeast.

31 March 2020

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Induction of epithelial differentiation and DNA demethylation in hamster malignant oral keratinocyte by ornithine decarboxylase antizyme

31 March 2020

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Polyamine metabolism and cancer.

31 March 2020

1 reference

Loss of spr-5 bypasses the requirement for the C.elegans presenilin sel-12 by derepressing hop-1.

31 March 2020

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Characterization of a Diamine Exporter in Chinese Hamster Ovary Cells and Identification of Specific Polyamine Substrates

31 March 2020

1 reference

Properties of purified recombinant human polyamine oxidase, PAOh1/SMO

31 March 2020

1 reference

Phase I study of methylacetylenic putrescine, an inhibitor of polyamine biosynthesis

31 March 2020

1 reference

Treatment of acute myeloid leukemia and blastic phase of chronic myeloid leukemia with combined eflornithine (alpha difluoromethylornithine) and methylglyoxal-bis-guanyl hydrazone (methyl-GAG).

31 March 2020

1 reference

Phase I trial of the polyamine analog N1,N14-diethylhomospermine (DEHSPM) in patients with advanced solid tumors

31 March 2020

1 reference

The influence of finasteride on the development of prostate cancer

31 March 2020

1 reference

Construction of an Escherichia coli strain unable to synthesize putrescine, spermidine, or cadaverine: characterization of two genes controlling lysine decarboxylase

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Fluorine-containing polyamines: biochemistry and potential applications

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRC1454

1 reference

PubMed ID

15510159

Dimensions Publication ID

1 August 2017

0 references

1 reference

PubMed ID

15510159