The antiviral drug ribavirin does not mimic the 7-methylguanosine moiety of the mRNA cap structure in vitro (Q34366602)

1 August 2017

title

The antiviral drug ribavirin does not mimic the 7-methylguanosine moiety of the mRNA cap structure in vitro (English)

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1 August 2017

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11

Thomas Preiss

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1 August 2017

9

Edward Darzynkiewicz

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1 August 2017

7

Jacek Jemielity

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1 August 2017

Remigiusz Worch

5

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ORCID Public Data File 2021

author name string

Belinda Westman

1

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1 August 2017

Lisa Beeren

2

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1 August 2017

Ewa Grudzien

3

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1 August 2017

Janusz Stepinski

4

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1 August 2017

Joanna Zuberek

6

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1 August 2017

Ryszard Stolarski

8

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1 August 2017

Robert E Rhoads

10

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1 August 2017

language of work or name

English

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publication date

30 August 2005

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1 August 2017

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1 August 2017

volume

11

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1 August 2017

issue

10

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1 August 2017

page(s)

1505-1513

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Ribavirin is not a functional mimic of the 7-methyl guanosine mRNA cap.

1 August 2017

cites work

1 reference

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Specificity of recognition of mRNA 5' cap by human nuclear cap-binding complex

6 July 2018

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Regulation of cap-dependent translation by eIF4E inhibitory proteins

6 July 2018

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Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap

6 July 2018

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Novel cap analogs for in vitro synthesis of mRNAs with high translational efficiency

6 July 2018

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The mRNA cap-binding protein eIF4E in post-transcriptional gene expression

6 July 2018

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eIF-4E expression and its role in malignancies and metastases.

6 July 2018

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Starting the protein synthesis machine: eukaryotic translation initiation.

6 July 2018

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mTOR Signaling to Translation

6 July 2018

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Novel "anti-reverse" cap analogs with superior translational properties

6 July 2018

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Eukaryotic translation initiation factors and regulators

6 July 2018

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Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation?

6 July 2018

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Large-scale induced fit recognition of an m(7)GpppG cap analogue by the human nuclear cap-binding complex

6 July 2018

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Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins

6 July 2018

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The mechanism of action of ribavirin: lethal mutagenesis of RNA virus genomes mediated by the viral RNA-dependent RNA polymerase

6 July 2018

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Synthesis and properties of mRNAs containing the novel "anti-reverse" cap analogs 7-methyl(3'-O-methyl)GpppG and 7-methyl (3'-deoxy)GpppG

6 July 2018

1 reference

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Picornavirus IRESes and the poly(A) tail jointly promote cap-independent translation in a mammalian cell-free system

6 July 2018

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Functional dissection of eukaryotic initiation factor 4F: the 4A subunit and the central domain of the 4G subunit are sufficient to mediate internal entry of 43S preinitiation complexes

6 July 2018

1 reference

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Canonical eukaryotic initiation factors determine initiation of translation by internal ribosomal entry

6 July 2018

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Translational control of programmed cell death: eukaryotic translation initiation factor 4E blocks apoptosis in growth-factor-restricted fibroblasts with physiologically expressed or deregulated Myc.

6 July 2018

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An essential E box in the promoter of the gene encoding the mRNA cap-binding protein (eukaryotic initiation factor 4E) is a target for activation by c-myc

6 July 2018

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In vitro characterization of an internal ribosomal entry site (IRES) present within the 5' nontranslated region of hepatitis A virus RNA: comparison with the IRES of encephalomyocarditis virus

6 July 2018

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Decreasing the level of translation initiation factor 4E with antisense RNA causes reversal of ras-mediated transformation and tumorigenesis of cloned rat embryo fibroblasts.

6 July 2018

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Reduction of translation initiation factor 4E decreases the malignancy of ras-transformed cloned rat embryo fibroblasts

6 July 2018

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Mechanism of action of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole), a new broad-spectrum antiviral agent

6 July 2018

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Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

6 July 2018

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Overexpression of eukaryotic protein synthesis initiation factor 4E in HeLa cells results in aberrant growth and morphology

6 July 2018

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Expression of antisense RNA against initiation factor eIF-4E mRNA in HeLa cells results in lengthened cell division times, diminished translation rates, and reduced levels of both eIF-4E and the p220 component of eIF-4F.

6 July 2018

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6 July 2018

12 December 2020

Virazole (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide; a cytostatic agent

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Inhibition of influenza virus ribonucleic acid polymerase by ribavirin triphosphate

6 July 2018

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The broad spectrum antiviral nucleoside ribavirin as a substrate for a viral RNA capping enzyme

6 July 2018

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Phosphorylation of eIF4E attenuates its interaction with mRNA 5' cap analogs by electrostatic repulsion: intein-mediated protein ligation strategy to obtain phosphorylated protein

27 October 2018

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Selective killing of cancer cells based on translational control of a suicide gene.

27 October 2018

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A cancer gene therapy approach through translational control of a suicide gene

27 October 2018

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The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1370834

Quantitative assessment of mRNA cap analogues as inhibitors of in vitro translation.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1370834

Overexpression of eukaryotic initiation factor 4E (eIF4E) in breast carcinoma

27 October 2018

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PubMed

12 December 2020

Elevated expression of eIF4E and FGF-2 isoforms during vascularization of breast carcinomas

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PubMed

12 December 2020

Detection of the Proto-oncogene eIF4E in Larynx and Hypopharynx Cancers

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PubMed

12 December 2020

Identifiers

DOI

10.1261/RNA.2132505

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1 August 2017

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1 August 2017

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