Down syndrome and Alzheimer's disease: a link between development and aging (Q34366691)

1 August 2017

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title

Down syndrome and Alzheimer's disease: a link between development and aging (English)

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1 August 2017

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Lott IT

1

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PubMed ID

11553933

1 August 2017

Head E

series ordinal

2

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1 August 2017

1 January 2001

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Mental Retardation and Developmental Disabilities Research Reviews

1 August 2017

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1 August 2017

7

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1 August 2017

3

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1 August 2017

172-178

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Developmental and aging changes in the expression of amyloid precursor protein in Down syndrome brains.

1 August 2017

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Diagnosis of dementia in individuals with intellectual disability.

21 January 2018

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Molecular dating of senile plaques in the brains of individuals with Down syndrome and in aged dogs

21 January 2018

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Dementia in adults with Down syndrome: diagnostic challenges.

21 January 2018

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Correlations of glutathione peroxidase activity with memory impairment in adults with Down syndrome

21 January 2018

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Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations

21 January 2018

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beta-Amyloid converts an acute phase injury response to chronic injury responses

21 January 2018

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The neurobiologic consequences of Down syndrome

21 January 2018

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Complement activation by cross-linked truncated and chimeric full-length beta-amyloid

21 January 2018

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The cholinergic hypothesis of neuropsychiatric symptoms in Alzheimer's disease.

21 January 2018

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Cerebral metabolism as measured with positron emission tomography (PET) and [18F] 2-deoxy-D-glucose: healthy aging, Alzheimer's disease and Down syndrome.

21 January 2018

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APOE epsilon 4 influences the manifestation of Alzheimer's disease in adults with Down's syndrome.

21 January 2018

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Evidence-based pharmacological treatment of dementia

21 January 2018

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Sustained cognitive improvement following treatment of Alzheimer's disease with donepezil.

21 January 2018

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The presence of isoaspartic acid in beta-amyloid plaques indicates plaque age.

21 January 2018

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Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome

21 January 2018

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Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease

21 January 2018

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Antibodies from Down's syndrome patients bind to the same cholinergic neurofilament protein recognized by Alzheimer's disease antibodies.

21 January 2018

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21 January 2018

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Neuropathological changes in Down's syndrome hippocampal formation. Effect of age and apolipoprotein E genotype.

21 January 2018

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Early diagnosis of Alzheimer disease with positron emission tomography.

21 January 2018

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Early senile dementia in mongoloid idiocy.

21 January 2018

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Kinetic properties of bovine brain protein L-isoaspartyl methyltransferase determined using a synthetic isoaspartyl peptide substrate

21 January 2018

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Biomarkers of oxidative stress are significantly elevated in Down syndrome.

21 January 2018

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

21 January 2018

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Magnetic resonance imaging analysis of age-related changes in the brains of individuals with Down's syndrome

21 January 2018

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Alzheimer's disease in the parents of women with trisomic spontaneous abortions.

21 January 2018

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A prospective study of Alzheimer disease in Down syndrome.

21 January 2018

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Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.

21 January 2018

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Early amyloid deposition in the medial temporal lobe of young Down syndrome patients: a regional quantitative analysis.

21 January 2018

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Down's syndrome, aging, and Alzheimer's disease: a clinical review

21 January 2018

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The pathological association between Down syndrome and Alzheimer disease

21 January 2018

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The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome

21 January 2018

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The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease

21 January 2018

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Frequency of hippocampal formation atrophy in normal aging and Alzheimer's disease.

21 January 2018

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Early glycoxidation damage in brains from Down's syndrome.

21 January 2018

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Partial impairment of immune functions in peripheral blood leukocytes from aged men with Down's syndrome.

21 January 2018

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Effect of vitamin E on chromosomal aberrations in lymphocytes from patients with Down's syndrome

21 January 2018

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Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer's disease is related to the apolipoprotein E genotype.

21 January 2018

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Identification of osteocalcin as a permanent aging constituent of the bone matrix: basis for an accurate age at death determination

21 January 2018

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People with Down's syndrome can be distinguished on the basis of cholinergic dysfunction

21 January 2018

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Amino- and carboxyl-terminal heterogeneity of beta-amyloid peptides deposited in human brain.

21 January 2018

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A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study.

21 January 2018

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Down's syndrome in adults: brain metabolism.

21 January 2018

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In cortical cultures of trisomy 16 mouse brain the upregulated metallothionein-I/II fails to respond to H2O2 exposure or glutamate receptor stimulation

21 January 2018

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Evidence against increased oxidative DNA-damage in Down syndrome.

21 January 2018

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Presenilin-1 exists in the axoplasm fraction in the brains of aged Down's syndrome subjects and non-demented individuals.

21 January 2018

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Amyloid beta-protein and the genetics of Alzheimer's disease

21 January 2018

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Neuritic plaque amyloid in Alzheimer's disease is highly racemized

21 January 2018

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Temporal accrual of complement proteins in amyloid plaques in Down's syndrome with Alzheimer's disease

21 January 2018

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Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.

21 January 2018

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N-terminal heterogeneity of parenchymal and cerebrovascular Abeta deposits.

21 January 2018

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Aspartate residue 7 in amyloid beta-protein is critical for classical complement pathway activation: implications for Alzheimer's disease pathogenesis

21 January 2018

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Cell-type-specific enhancement of amyloid-beta deposition in a novel presenilin-1 mutation (P117L).

21 January 2018

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The role of perivascular and microglial cells in fibrillogenesis of beta-amyloid and PrP protein in Alzheimer's disease and scrapie

21 January 2018

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Cortical glucose metabolic rate correlates of abstract reasoning and attention studied with positron emission tomography

21 January 2018

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Low glucose metabolism during brain stimulation in older Down's syndrome subjects at risk for Alzheimer's disease prior to dementia.

21 January 2018

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Evidence against the involvement of reactive oxygen species in the pathogenesis of neuronal death in down's syndrome and Alzheimer's Disease

21 January 2018

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Beta-amyloid (beta/A4) deposition in the medial temporal lobe in Down's syndrome: effects of brain region and patient age

21 January 2018

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Brain cognition and metabolism in Down syndrome adults in association with development of dementia.

21 January 2018

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Small cerebral hemispheres in adults with Down's syndrome: contributions of developmental arrest and lesions of Alzheimer's disease.

21 January 2018

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Defective repair of oxidative damage in mitochondrial DNA in Down's syndrome

21 January 2018

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Diagnosis of Alzheimer's disease

21 January 2018

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Cholinergic therapy for Down's syndrome

21 January 2018

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Increased plasma amyloid beta protein 1-42 levels in Down syndrome

21 January 2018

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21 January 2018

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Selective neuroanatomic abnormalities in Down's syndrome and their cognitive correlates: evidence from MRI morphometry.

21 January 2018

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Estimation of age at death based on aspartic acid racemization in noncollagenous bone proteins

21 January 2018

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Presence of soluble amyloid beta-peptide precedes amyloid plaque formation in Down's syndrome

21 January 2018

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Presenilin 1 and ?-1-antichymotrypsin polymorphisms in down syndrome: No effect on the presence of dementia

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/MRDD.1025

1 reference

release_4rqzzmdaezamrpwjhyqngpl6om

1 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/4rqzzmdaezamrpwjhyqngpl6om

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

11553933

1 reference

PubMed ID

11553933