BET bromodomain inhibition suppresses TH17-mediated pathology (Q34375887)

1 August 2017

title

BET bromodomain inhibition suppresses TH17-mediated pathology (English)

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1 August 2017

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Deanna A Mele

1

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1 August 2017

Andres Salmeron

2

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1 August 2017

Srimoyee Ghosh

3

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1 August 2017

Hon-Ren Huang

4

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1 August 2017

Barbara M Bryant

5

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1 August 2017

Jose M Lora

6

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1 August 2017

language of work or name

English

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publication date

7 October 2013

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Journal of Experimental Medicine

1 August 2017

published in

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1 August 2017

volume

210

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1 August 2017

issue

11

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1 August 2017

page(s)

2181-2190

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A validated regulatory network for Th17 cell specification

1 August 2017

cites work

1 reference

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A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes

6 July 2018

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Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804955

The Th17 immune response is controlled by the Rel-RORγ-RORγ T transcriptional axis

6 July 2018

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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

6 July 2018

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Targeting MYC dependence in cancer by inhibiting BET bromodomains

6 July 2018

1 reference

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804955

Control of TH17 cells occurs in the small intestine.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804955

Suppression of inflammation by a synthetic histone mimic

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804955

Selective inhibition of BET bromodomains

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804955

Th17 and regulatory T cells in mediating and restraining inflammation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804955

Control of inducible gene expression by signal-dependent transcriptional elongation

6 July 2018

1 reference

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A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling

6 July 2018

1 reference

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The AP-1 transcription factor Batf controls T(H)17 differentiation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804955

Genome-wide analysis of histone methylation reveals chromatin state-based regulation of gene transcription and function of memory CD8+ T cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804955

Critical regulation of early Th17 cell differentiation by interleukin-1 signaling

6 July 2018

1 reference

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Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804955

6 July 2018

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The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804955

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804955

T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804955

Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804955

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804955

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804955

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804955

The NF- B Transcription Factor c-Rel Is Required for Th17 Effector Cell Development in Experimental Autoimmune Encephalomyelitis

6 July 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24101376

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24101376

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24101376

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1084/JEM.20130376

1 reference

1 August 2017

1 reference

1 August 2017

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