Inhibition of AKT with the orally active allosteric AKT inhibitor, MK-2206, sensitizes endometrial cancer cells to progestin (Q34388048)

1 August 2017

Inhibition of AKT with the orally active allosteric AKT inhibitor, MK-2206, sensitizes endometrial cancer cells to progestin (English)

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1 August 2017

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Alok Pant

1

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1 August 2017

Irene I Lee

2

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1 August 2017

Zhenxiao Lu

3

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1 August 2017

Bo R Rueda

4

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1 August 2017

Julian Schink

5

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1 August 2017

J Julie Kim

6

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1 August 2017

language of work or name

English

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publication date

24 July 2012

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1 August 2017

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1 August 2017

7

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1 August 2017

e41593

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1 August 2017

7

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Creative Commons Attribution 4.0 International

1 August 2017

start time

24 July 2012

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

limma

object named as

limma

2 references

22 June 2022

https://europepmc.org/article/PMC/3404036

inferred from PubMed Central ID database lookup

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

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MK-2206, a novel allosteric inhibitor of Akt, synergizes with gefitinib against malignant glioma via modulating both autophagy and apoptosis

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First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors

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Inhibiting the PI3K/Akt pathway reversed progestin resistance in endometrial cancer

6 July 2018

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Combination treatment with MEK and AKT inhibitors is more effective than each drug alone in human non-small cell lung cancer in vitro and in vivo

6 July 2018

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MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo

6 July 2018

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Sparing fertility in young patients with endometrial cancer

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The regulation and function of the forkhead transcription factor, Forkhead box O1, is dependent on the progesterone receptor in endometrial carcinoma

6 July 2018

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A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

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6 July 2018

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6 July 2018

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Protein kinase B-alpha inhibits human pyruvate dehydrogenase kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors

6 July 2018

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6 July 2018

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6 July 2018

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Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B

6 July 2018

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6 July 2018

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21 January 2018

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21 January 2018

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27 October 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/22911820

12 December 2020

inferred from PubMed ID database lookup

Progestin treatment of atypical hyperplasia and well-differentiated carcinoma of the endometrium in women under age 40

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22911820

12 December 2020

inferred from PubMed ID database lookup

Loss of PTEN expression followed by Akt phosphorylation is a poor prognostic factor for patients with endometrial cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22911820

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1371/JOURNAL.PONE.0041593

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1 August 2017

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1 August 2017

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