Mutant amyloid precursor protein differentially alters adipose biology under obesogenic and non-obesogenic conditions (Q34389397)

1 August 2017

Mutant amyloid precursor protein differentially alters adipose biology under obesogenic and non-obesogenic conditions (English)

1 reference

1 August 2017

Linnea R Freeman

1

1 reference

1 August 2017

Le Zhang

2

1 reference

1 August 2017

Kalavathi Dasuri

3

1 reference

1 August 2017

Sun-Ok Fernandez-Kim

4

1 reference

1 August 2017

Annadora J Bruce-Keller

5

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1 August 2017

Jeffrey N Keller

6

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1 August 2017

language of work or name

English

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publication date

17 August 2012

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1 August 2017

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1 August 2017

7

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1 August 2017

8

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1 August 2017

e43193

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Creative Commons Attribution 4.0 International

1 August 2017

start time

17 August 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Amyloid precursor protein and proinflammatory changes are regulated in brain and adipose tissue in a murine model of high fat diet-induced obesity

6 July 2018

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6 July 2018

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Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice.

6 July 2018

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APP physiological and pathophysiological functions: insights from animal models.

6 July 2018

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Central obesity in the elderly is related to late-onset Alzheimer disease

6 July 2018

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Role of APP and Aβ in synaptic physiology

6 July 2018

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Aging is associated with hypoxia and oxidative stress in adipose tissue: implications for adipose function.

6 July 2018

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6 July 2018

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Enhanced capillary amyloid angiopathy-associated pathology in Tg-SwDI mice with deleted nitric oxide synthase 2

6 July 2018

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Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease

6 July 2018

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Leptin: the missing link in Alzheimer disease?

6 July 2018

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Macrophages, inflammation, and insulin resistance

6 July 2018

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Amyloid precursor protein expression is induced by tumor necrosis factor alpha in 3T3-L1 adipocytes

6 July 2018

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Caloric restriction attenuates amyloid deposition in middle-aged dtg APP/PS1 mice

6 July 2018

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Roles and regulation of Thy-1, a context-dependent modulator of cell phenotype

6 July 2018

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Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

The role of metabolic disorders in Alzheimer disease and vascular dementia: two roads converged

6 July 2018

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Adipose tissue expandability and the metabolic syndrome

6 July 2018

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Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy

6 July 2018

1 reference

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Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2

6 July 2018

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Cerebral amyloid angiopathy: pathogenetic mechanisms and link to dense amyloid plaques.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

Inflammation, obesity and comorbidities: the role of diet.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

Intracellular amyloid-beta in Alzheimer's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

The APP family of proteins: similarities and differences

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

Adipocytes as regulators of energy balance and glucose homeostasis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

Inflammation and insulin resistance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

Glucose-fatty acid interaction in skeletal muscle and adipose tissue in insulin resistance.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

Human adipose tissue-derived mesenchymal stem cells differentiate into insulin, somatostatin, and glucagon expressing cells.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

Endocrine and signalling role of adipose tissue: new perspectives on fat.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

Adipose tissue, adipokines, and inflammation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

Effects of obesity on the relationship of leptin mRNA expression and adipocyte size in anatomically distinct fat depots in mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

BACE1 (beta-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

Synergistic effects of hypoxia and insulin are regulated by different transcriptional elements of the human leptin promoter

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

Increased amyloid- levels in APPSWE transgenic mice treated chronically with a physiological high-fat high-cholesterol diet

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

Mouse models of Alzheimer's disease: a quest for plaques and tangles

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

Interaction between the two ubiquitously expressed transcription factors NF-Y and Sp1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

APP gene promoter constructs are preferentially expressed in the CNS and testis of transgenic mice.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

Aβ Imaging: feasible, pertinent, and vital to progress in Alzheimer's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

Amyloid precursor protein expression is upregulated in adipocytes in obesity.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

Amyloid precursor protein knockout mice show age-dependent deficits in passive avoidance learning.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

Relationship between adipocyte size and adipokine expression and secretion

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

Transcriptional regulation of APH-1A and increased gamma-secretase cleavage of APP and Notch by HIF-1 and hypoxia.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

Pathogenic accumulation of APP in fast twitch muscle of IBM patients and a transgenic model

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422309

Adipocyte functions are modulated by cell size change: potential involvement of an integrin/ERK signalling pathway

27 October 2018

1 reference

12 December 2020

Adipose tissue as an endocrine organ

1 reference

12 December 2020

Cells from peripheral tissues that exhibit high APP expression are characterized by their high membrane fusion activity

1 reference

12 December 2020

Adipose tissue inflammation in obesity and metabolic syndrome

1 reference

12 December 2020

Cellular and transgenic animal models of cerebrovascular amyloidosis

1 reference

12 December 2020

Regulation of leptin promoter function by Sp1, C/EBP, and a novel factor

1 reference

12 December 2020

Transgenic expression of beta-APP in fast-twitch skeletal muscle leads to calcium dyshomeostasis and IBM-like pathology

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0043193

Identifiers

DOI

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1 August 2017

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1 August 2017

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