Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide (Q34390387)

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English	Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide	scientific article

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scholarly article

1 reference

Europe PubMed Central

1 August 2017

Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide (English)

1 reference

Europe PubMed Central

1 August 2017

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glyceryl 2-arachidonate

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based on heuristic

inferred from title

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based on heuristic

inferred from title

author name string

C J Fowler

1

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Europe PubMed Central

1 August 2017

K O Jonsson

2

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Europe PubMed Central

1 August 2017

G Tiger

3

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Europe PubMed Central

1 August 2017

language of work or name

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publication date

1 September 2001

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Europe PubMed Central

1 August 2017

Biochemical Pharmacology

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Europe PubMed Central

1 August 2017

62

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Europe PubMed Central

1 August 2017

5

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Europe PubMed Central

1 August 2017

517-526

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Europe PubMed Central

1 August 2017

Endocannabinoids

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Biochemistry and pharmacology of the endocannabinoids arachidonylethanolamide and 2-arachidonylglycerol

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The endocannabinoid system as a target for therapeutic drugs.

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Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action.

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Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide

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Analogues and homologues of N-palmitoylethanolamide, a putative endogenous CB(2) cannabinoid, as potential ligands for the cannabinoid receptors

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N-(2-hydroxyethyl)hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by down-modulating mast cell activation

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Control of pain initiation by endogenous cannabinoids.

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The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain.

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A proposed autacoid mechanism controlling mastocyte behaviour

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Stereoselective modulatory actions of oleamide on GABA(A) receptors and voltage-gated Na(+) channels in vitro: a putative endogenous ligand for depressant drug sites in CNS.

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Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist

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Catabolism of N-acylethanolamine phospholipids by dog brain preparations.

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Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

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Oxidative metabolism of anandamide

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Influence of phenylmethylsulfonyl fluoride on anandamide brain levels and pharmacological effects

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Effect of phenylmethylsulphonyl fluoride on the potency of anandamide as an inhibitor of electrically evoked contractions in two isolated tissue preparations

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Anandamide amidohydrolase activity in rat brain microsomes. Identification and partial characterization

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Metabolism of anandamide, an endogenous cannabinoid receptor ligand, in porcine ocular tissues

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Distribution and characterization of anandamide amidohydrolase in mouse brain and liver.

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7 January 2021

Down-regulation of anandamide hydrolase in mouse uterus by sex hormones

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Characterization of the kinetics and distribution of N-arachidonylethanolamine (anandamide) hydrolysis by rat brain

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Inhibition of anandamide hydrolysis by the enantiomers of ibuprofen, ketorolac, and flurbiprofen.

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Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistry

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Fatty acid amide hydrolase expression in rat choroid plexus: possible role in regulation of the sleep-inducing action of oleamide.

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A new perspective on cannabinoid signalling: complementary localization of fatty acid amide hydrolase and the CB1 receptor in rat brain

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Immunocytochemical localization of cannabinoid CB1 receptor and fatty acid amide hydrolase in rat retina

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Activation of rabbit blood platelets by anandamide through its cleavage into arachidonic acid

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Human platelets and polymorphonuclear leukocytes synthesize oxygenated derivatives of arachidonylethanolamide (anandamide): their affinities for cannabinoid receptors and pathways of inactivation.

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Biosynthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophages

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Relation between decreased anandamide hydrolase concentrations in human lymphocytes and miscarriage

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Occurrence and metabolism of anandamide and related acyl-ethanolamides in ovaries of the sea urchin Paracentrotus lividus.

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Differences in the pharmacological properties of rat and chicken brain fatty acid amidohydrolase

1 reference

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Biosynthesis, uptake, and degradation of anandamide and palmitoylethanolamide in leukocytes

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Identification of two serine residues involved in catalysis by fatty acid amide hydrolase

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Human mast cells take up and hydrolyze anandamide under the control of 5-lipoxygenase and do not express cannabinoid receptors

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Partial purification and characterization of the porcine brain enzyme hydrolyzing and synthesizing anandamide

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Determination of anandamide amidase activity using ultraviolet-active amine derivatives and reverse-phase high-performance liquid chromatography.

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Pharmacological properties of rat brain fatty acid amidohydrolase in different subcellular fractions using palmitoylethanolamide as substrate

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Two novel classes of neuroactive fatty acid amides are substrates for mouse neuroblastoma ‘anandamide amidohydrolase’

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An acid amidase hydrolyzing anandamide as an endogenous ligand for cannabinoid receptors

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Arachidonoyl ethanolamide-[1,2-14C] as a substrate for anandamide amidase.

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Anandamide hydrolysis by human cells in culture and brain.

1 reference

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Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase.

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The cloned rat hydrolytic enzyme responsible for the breakdown of anandamide also catalyzes its formation via the condensation of arachidonic acid and ethanolamine.

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Equilibrium in the hydrolysis and synthesis of cannabimimetic anandamide demonstrated by a purified enzyme.

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Enzymes of porcine brain hydrolyzing 2-arachidonoylglycerol, an endogenous ligand of cannabinoid receptors.

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A fluorescence displacement assay for the measurement of arachidonoyl ethanolamide (anandamide) and oleoyl amide (octadecenoamide) hydrolysis

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Study of the amidase signature group

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Molecular characterization of human and mouse fatty acid amide hydrolases

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Anandamide amidohydrolase of porcine brain: cDNA cloning, functional expression and site-directed mutagenesis(1).

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Chemical and mutagenic investigations of fatty acid amide hydrolase: evidence for a family of serine hydrolases with distinct catalytic properties

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Clarifying the catalytic roles of conserved residues in the amidase signature family

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Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor

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Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase.

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N-acyl-dopamines: novel synthetic CB(1) cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo

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An endogenous sleep-inducing compound is a novel competitive inhibitor of fatty acid amide hydrolase

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Methyl arachidonyl fluorophosphonate: a potent irreversible inhibitor of anandamide amidase

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Ibuprofen inhibits the metabolism of the endogenous cannabimimetic agent anandamide

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Anandamide amidase inhibition enhances anandamide-stimulated nitric oxide release in invertebrate neural tissues.

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N-acylethanolamine phospholipid metabolism in normal and ischemic rat brain

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Determination of the phospholipid precursor of anandamide and other N-acylethanolamine phospholipids before and after sodium azide-induced toxicity in cultured neocortical neurons

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The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons

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Neurotoxicity of glutamate in chick telencephalon neurons: reduction of toxicity by preincubation with carbachol, but not by the endogenous fatty acid amides anandamide and palmitoylethanolamide

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Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors

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10.1016/S0006-2952(01)00712-2

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Europe PubMed Central

1 August 2017

1 reference

Europe PubMed Central

1 August 2017

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